INPP4A: Difference between revisions

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{{Infobox_gene}}
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'''Type I inositol-3,4-bisphosphate 4-phosphatase''' is an [[enzyme]] that in humans is encoded by the ''INPP4A'' [[gene]].<ref name="pmid7608176">{{cite journal |vauthors=Norris FA, Auethavekiat V, Majerus PW | title = The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase | journal = J Biol Chem | volume = 270 | issue = 27 | pages = 16128–33 |date=Aug 1995 | pmid = 7608176 | pmc =  | doi =10.1074/jbc.270.27.16128 }}</ref><ref name="pmid9295334">{{cite journal |vauthors=Norris FA, Atkins RC, Majerus PW | title = The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family | journal = J Biol Chem | volume = 272 | issue = 38 | pages = 23859–64 |date=Oct 1997 | pmid = 9295334 | pmc =  | doi =10.1074/jbc.272.38.23859 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3631| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Inositol polyphosphate-4-phosphatase, type I, 107kDa
| HGNCid = 6074
| Symbol = INPP4A
| AltSymbols =; INPP4
| OMIM = 600916
| ECnumber =
| Homologene = 2871
| MGIid = 1931123
  | GeneAtlas_image1 = PBB_GE_INPP4A_204553_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_INPP4A_208363_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_INPP4A_208364_at_tn.png
  | Function = {{GNF_GO|id=GO:0016316 |text = phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3631
    | Hs_Ensembl = ENSG00000040933
    | Hs_RefseqProtein = NP_001557
    | Hs_RefseqmRNA = NM_001566
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 98427753
    | Hs_GenLoc_end = 98570554
    | Hs_Uniprot = Q96PE3
    | Mm_EntrezGene = 269180
    | Mm_Ensembl = ENSMUSG00000026113
    | Mm_RefseqmRNA = XM_978104
    | Mm_RefseqProtein = XP_983198
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 37302465
    | Mm_GenLoc_end = 37352805
    | Mm_Uniprot = Q3UEQ1
  }}
}}
'''Inositol polyphosphate-4-phosphatase, type I, 107kDa''', also known as '''INPP4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3631| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.<ref name="entrez">{{cite web | title = Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3631| accessdate = }}</ref>
| summary_text = INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in [[phosphatidylinositol]] signaling pathways. This enzyme removes the phosphate group at position 4 of the [[inositol]] ring from inositol 3,4-bisphosphate.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhang X, Majerus PW |title=Phosphatidylinositol signalling reactions. |journal=Semin. Cell Dev. Biol. |volume=9 |issue= 2 |pages= 153-60 |year= 1998 |pmid= 9599410 |doi= 10.1006/scdb.1997.0220 }}
*{{cite journal  |vauthors=Zhang X, Majerus PW |title=Phosphatidylinositol signalling reactions. |journal=Semin. Cell Dev. Biol. |volume=9 |issue= 2 |pages= 153–60 |year= 1998 |pmid= 9599410 |doi= 10.1006/scdb.1997.0220 }}
*{{cite journal  | author=Norris FA, Auethavekiat V, Majerus PW |title=The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 27 |pages= 16128-33 |year= 1995 |pmid= 7608176 |doi=  }}
*{{cite journal  |vauthors=Norris FA, Atkins RC, Majerus PW |title=Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 10987–9 |year= 1997 |pmid= 9110986 |doi=10.1074/jbc.272.17.10987 }}
*{{cite journal  | author=Norris FA, Atkins RC, Majerus PW |title=Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 10987-9 |year= 1997 |pmid= 9110986 |doi= }}
*{{cite journal   |vauthors=Munday AD, Norris FA, Caldwell KK, etal |title=The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3640–5 |year= 1999 |pmid= 10097090 |doi=10.1073/pnas.96.7.3640  | pmc=22347 }}
*{{cite journal  | author=Norris FA, Atkins RC, Majerus PW |title=The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23859-64 |year= 1997 |pmid= 9295334 |doi= }}
*{{cite journal  |vauthors=Joseph RE, Walker J, Norris FA |title=Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 276–7 |year= 2000 |pmid= 10702694 |doi=10.1159/000015448 }}
*{{cite journal | author=Munday AD, Norris FA, Caldwell KK, ''et al.'' |title=The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3640-5 |year= 1999 |pmid= 10097090 |doi=  }}
*{{cite journal  |vauthors=Shearn CT, Walker J, Norris FA |title=Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 1 |pages= 119–25 |year= 2001 |pmid= 11485317 |doi= 10.1006/bbrc.2001.5331 }}
*{{cite journal  | author=Joseph RE, Walker J, Norris FA |title=Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 276-7 |year= 2000 |pmid= 10702694 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Shearn CT, Walker J, Norris FA |title=Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 1 |pages= 119-25 |year= 2001 |pmid= 11485317 |doi= 10.1006/bbrc.2001.5331 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Ivetac I, Munday AD, Kisseleva MV, etal |title=The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. |journal=Mol. Biol. Cell |volume=16 |issue= 5 |pages= 2218–33 |year= 2005 |pmid= 15716355 |doi= 10.1091/mbc.E04-09-0799 | pmc=1087230 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Ivetac I, Munday AD, Kisseleva MV, ''et al.'' |title=The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. |journal=Mol. Biol. Cell |volume=16 |issue= 5 |pages= 2218-33 |year= 2005 |pmid= 15716355 |doi= 10.1091/mbc.E04-09-0799 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 14:08, 16 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.[1][2][3]

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.[3]

References

  1. ↑ Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
  2. ↑ Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.
  3. ↑ 3.0 3.1 "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

Further reading



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