INPP5B: Difference between revisions

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{{Infobox_gene}}
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'''Type II inositol-1,4,5-trisphosphate 5-phosphatase''' is an [[enzyme]] that in humans is encoded by the ''INPP5B'' [[gene]].<ref name="pmid1718960">{{cite journal |vauthors=Ross TS, Jefferson AB, Mitchell CA, Majerus PW | title = Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase | journal = J Biol Chem | volume = 266 | issue = 30 | pages = 20283–9 |date=Dec 1991 | pmid = 1718960 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3633| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Inositol polyphosphate-5-phosphatase, 75kDa
| HGNCid = 6077
| Symbol = INPP5B
| AltSymbols =; 5PTase; MGC65156; MGC71303
| OMIM = 147264
| ECnumber = 
| Homologene = 69021
| MGIid = 103257
| GeneAtlas_image1 = PBB_GE_INPP5B_213643_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_INPP5B_213804_at_tn.png
| Function = {{GNF_GO|id=GO:0004439 |text = phosphoinositide 5-phosphatase activity}} {{GNF_GO|id=GO:0004445 |text = inositol-polyphosphate 5-phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3633
    | Hs_Ensembl = ENSG00000204084
    | Hs_RefseqProtein = NP_005531
    | Hs_RefseqmRNA = NM_005540
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 38098956
    | Hs_GenLoc_end = 38185310
    | Hs_Uniprot = P32019
    | Mm_EntrezGene = 16330
    | Mm_Ensembl = ENSMUSG00000028894
    | Mm_RefseqmRNA = XM_622561
    | Mm_RefseqProtein = XP_622561
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 124244838
    | Mm_GenLoc_end = 124303815
    | Mm_Uniprot = 
  }}
}}
'''Inositol polyphosphate-5-phosphatase, 75kDa''', also known as '''INPP5B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3633| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3633| accessdate = }}</ref>
| summary_text = Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3633| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ross TS, Jefferson AB, Mitchell CA, Majerus PW |title=Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 20283-9 |year= 1991 |pmid= 1718960 |doi=  }}
*{{cite journal  |vauthors=Mitchell CA, Connolly TM, Majerus PW |title=Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. |journal=J. Biol. Chem. |volume=264 |issue= 15 |pages= 8873–7 |year= 1989 |pmid= 2542294 |doi=  }}
*{{cite journal  | author=Mitchell CA, Connolly TM, Majerus PW |title=Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. |journal=J. Biol. Chem. |volume=264 |issue= 15 |pages= 8873-7 |year= 1989 |pmid= 2542294 |doi=  }}
*{{cite journal  |vauthors=Jefferson AB, Majerus PW |title=Properties of type II inositol polyphosphate 5-phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9370–7 |year= 1995 |pmid= 7721860 |doi=10.1074/jbc.270.16.9370 }}
*{{cite journal  | author=Jefferson AB, Majerus PW |title=Properties of type II inositol polyphosphate 5-phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9370-7 |year= 1995 |pmid= 7721860 |doi=  }}
*{{cite journal   |vauthors=Jänne PA, Dutra AS, Dracopoli NC, etal |title=Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 3 |pages= 164–6 |year= 1994 |pmid= 8125013 |doi=10.1159/000133691 }}
*{{cite journal | author=Jänne PA, Dutra AS, Dracopoli NC, ''et al.'' |title=Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 3 |pages= 164-6 |year= 1994 |pmid= 8125013 |doi=  }}
*{{cite journal  |vauthors=Speed CJ, Matzaris M, Bird PI, Mitchell CA |title=Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. |journal=Eur. J. Biochem. |volume=234 |issue= 1 |pages= 216–24 |year= 1996 |pmid= 8529643 |doi=10.1111/j.1432-1033.1995.216_c.x }}
*{{cite journal  | author=Speed CJ, Matzaris M, Bird PI, Mitchell CA |title=Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. |journal=Eur. J. Biochem. |volume=234 |issue= 1 |pages= 216-24 |year= 1996 |pmid= 8529643 |doi=  }}
*{{cite journal   |vauthors=Jänne PA, Rochelle JM, Martin-DeLeon PA, etal |title=Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens. |journal=Genomics |volume=28 |issue= 2 |pages= 280–5 |year= 1996 |pmid= 8530037 |doi= 10.1006/geno.1995.1142 }}
*{{cite journal | author=Jänne PA, Rochelle JM, Martin-DeLeon PA, ''et al.'' |title=Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens. |journal=Genomics |volume=28 |issue= 2 |pages= 280-5 |year= 1996 |pmid= 8530037 |doi= 10.1006/geno.1995.1142 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 23:53, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[1][2]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

References

  1. ↑ Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. PMID 1718960.
  2. ↑ 2.0 2.1 "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading



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