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{{Infobox_gene}}
{{GNF_Protein_box
'''Integrator complex subunit 6''' is a [[protein]] that in humans is encoded by the ''INTS6'' [[gene]].<ref name="pmid10467397">{{cite journal |vauthors=Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH | title = Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas | journal = Oncogene | volume = 18 | issue = 32 | pages = 4530–7 |date=Oct 1999 | pmid = 10467397 | pmc =  | doi = 10.1038/sj.onc.1202806 }}</ref><ref name="pmid16239144">{{cite journal |vauthors=Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R | title = Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II | journal = Cell | volume = 123 | issue = 2 | pages = 265–76 |date=Oct 2005 | pmid = 16239144 | pmc =  | doi = 10.1016/j.cell.2005.08.019 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INTS6 integrator complex subunit 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26512| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Integrator complex subunit 6
| HGNCid = 14879
| Symbol = INTS6
| AltSymbols =; INT6; DBI-1; DDX26; DDX26A; DICE1; DKFZP434B105; HDB; Notchl2
| OMIM = 604331
| ECnumber = 
| Homologene = 8121
| MGIid = 1202397
| GeneAtlas_image1 = PBB_GE_INTS6_222239_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_INTS6_218819_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0032039 |text = integrator complex}}
| Process = {{GNF_GO|id=GO:0016180 |text = snRNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26512
    | Hs_Ensembl = ENSG00000102786
    | Hs_RefseqProtein = NP_001035026
    | Hs_RefseqmRNA = NM_001039937
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 50837365
    | Hs_GenLoc_end = 50925150
    | Hs_Uniprot = Q9UL03
    | Mm_EntrezGene = 18130
    | Mm_Ensembl = ENSMUSG00000035161
    | Mm_RefseqmRNA = NM_008715
    | Mm_RefseqProtein = NP_032741
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 61630430
    | Mm_GenLoc_end = 61715222
    | Mm_Uniprot = Q6PCM2
  }}
}}
'''Integrator complex subunit 6''', also known as '''INTS6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INTS6 integrator complex subunit 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26512| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: INTS6 integrator complex subunit 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26512| accessdate = }}</ref>
| summary_text = [[DEAD box]] proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative [[RNA]] [[helicases]]. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of [[RNA polymerase II]] and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate [[tumor suppressor]] and located in the critical region of [[loss of heterozygosity]] (LOH). Three transcript variants encoding two different [[isoforms]] have been found for this gene.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Buchsbaum S, Morris C, Bochard V, Jalinot P |title=Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle. |journal=Oncogene |volume=26 |issue= 35 |pages= 5132-44 |year= 2007 |pmid= 17310990 |doi= 10.1038/sj.onc.1210314 }}
*{{cite journal  |vauthors=Buchsbaum S, Morris C, Bochard V, Jalinot P |title=Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle. |journal=Oncogene |volume=26 |issue= 35 |pages= 5132–44 |year= 2007 |pmid= 17310990 |doi= 10.1038/sj.onc.1210314 }}
*{{cite journal  | author=Hernández M, Papadopoulos N, Almeida TA |title=Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. |journal=Cancer Genet. Cytogenet. |volume=163 |issue= 1 |pages= 91-2 |year= 2006 |pmid= 16271964 |doi= 10.1016/j.cancergencyto.2005.04.014 }}
*{{cite journal  |vauthors=Hernández M, Papadopoulos N, Almeida TA |title=Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. |journal=Cancer Genet. Cytogenet. |volume=163 |issue= 1 |pages= 91–2 |year= 2006 |pmid= 16271964 |doi= 10.1016/j.cancergencyto.2005.04.014 }}
*{{cite journal | author=Baillat D, Hakimi MA, Näär AM, ''et al.'' |title=Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. |journal=Cell |volume=123 |issue= 2 |pages= 265-76 |year= 2005 |pmid= 16239144 |doi= 10.1016/j.cell.2005.08.019 }}
*{{cite journal   |vauthors=Röpke A, Buhtz P, Böhm M, etal |title=Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. |journal=Oncogene |volume=24 |issue= 44 |pages= 6667–75 |year= 2005 |pmid= 16007164 |doi= 10.1038/sj.onc.1208824 }}
*{{cite journal  | author=Röpke A, Buhtz P, Böhm M, ''et al.'' |title=Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. |journal=Oncogene |volume=24 |issue= 44 |pages= 6667-75 |year= 2005 |pmid= 16007164 |doi= 10.1038/sj.onc.1208824 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Wieland I, Sell C, Weidle UH, Wieacker P |title=Ectopic expression of DICE1 suppresses tumor cell growth. |journal=Oncol. Rep. |volume=12 |issue= 2 |pages= 207–11 |year= 2005 |pmid= 15254679 |doi=  10.3892/or.12.2.207}}
*{{cite journal  | author=Wieland I, Sell C, Weidle UH, Wieacker P |title=Ectopic expression of DICE1 suppresses tumor cell growth. |journal=Oncol. Rep. |volume=12 |issue= 2 |pages= 207-11 |year= 2005 |pmid= 15254679 |doi=  }}
*{{cite journal   |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
*{{cite journal | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Li WJ, Hu N, Su H, etal |title=Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma. |journal=Oncogene |volume=22 |issue= 2 |pages= 314–8 |year= 2003 |pmid= 12527901 |doi= 10.1038/sj.onc.1206098 }}
*{{cite journal | author=Li WJ, Hu N, Su H, ''et al.'' |title=Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma. |journal=Oncogene |volume=22 |issue= 2 |pages= 314-8 |year= 2003 |pmid= 12527901 |doi= 10.1038/sj.onc.1206098 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Wieland I, Röpke A, Stumm M, etal |title=Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. |journal=Oncol. Res. |volume=12 |issue= 11–12 |pages= 491–500 |year= 2002 |pmid= 11939413 |doi=  }}
*{{cite journal | author=Wieland I, Röpke A, Stumm M, ''et al.'' |title=Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. |journal=Oncol. Res. |volume=12 |issue= 11-12 |pages= 491-500 |year= 2002 |pmid= 11939413 |doi=  }}
*{{cite journal   |vauthors=Camargo AA, Nunes DN, Samaia HB, etal |title=Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12. |journal=Braz. J. Med. Biol. Res. |volume=34 |issue= 10 |pages= 1237–45 |year= 2002 |pmid= 11593297 |doi=  10.1590/s0100-879x2001001000002}}
*{{cite journal | author=Camargo AA, Nunes DN, Samaia HB, ''et al.'' |title=Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12. |journal=Braz. J. Med. Biol. Res. |volume=34 |issue= 10 |pages= 1237-45 |year= 2002 |pmid= 11593297 |doi=  }}
*{{cite journal  | author=Wieland I, Arden KC, Michels D, ''et al.'' |title=Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. |journal=Oncogene |volume=18 |issue= 32 |pages= 4530-7 |year= 1999 |pmid= 10467397 |doi= 10.1038/sj.onc.1202806 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:33, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[1][2][3]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[3]

References

  1. ↑ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
  2. ↑ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
  3. ↑ 3.0 3.1 "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading



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