ITIH4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Inter-alpha-trypsin inhibitor heavy chain H4''' is a [[protein]] that in humans is encoded by the ''ITIH4'' [[gene]].<ref name="pmid9480842">{{cite journal |vauthors=Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP | title = The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human | journal = Biochem Biophys Res Commun | volume = 243 | issue = 2 | pages = 522–30 |date=Mar 1998 | pmid = 9480842 | pmc =  | doi = 10.1006/bbrc.1998.8128 }}</ref><ref name="pmid7805892">{{cite journal |vauthors=Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S | title = cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein | journal = FEBS Lett | volume = 357 | issue = 2 | pages = 207–11 |date=Feb 1995 | pmid = 7805892 | pmc =  | doi =10.1016/0014-5793(94)01364-7  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3700| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
* [[Inter-alpha-trypsin inhibitor]]
| image =
* [[ITIH1]]
| image_source =
* [[ITIH2]]
| PDB =
* [[ITIH3]]
| Name = Inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
| HGNCid = 6169
| Symbol = ITIH4
| AltSymbols =; DKFZp686G21125; H4P; IHRP; ITIHL1; PK120
| OMIM = 600564
| ECnumber = 
| Homologene = 1670
| MGIid = 109536
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0030212 |text = hyaluronan metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3700
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002209
    | Hs_RefseqmRNA = NM_002218
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 16427
    | Mm_Ensembl = ENSMUSG00000021922
    | Mm_RefseqmRNA = NM_018746
    | Mm_RefseqProtein = NP_061216
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 29715511
    | Mm_GenLoc_end = 29730990
    | Mm_Uniprot = 
  }}
}}
'''Inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)''', also known as '''ITIH4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3700| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Choi-Miura NH, Sano Y, Oda E, etal |title=Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. |journal=J. Biochem. |volume=117 |issue= 2 |pages= 400–7 |year= 1995 |pmid= 7541790 |doi=10.1093/jb/117.2.400 }}
| citations =
*{{cite journal   |vauthors=Tobe T, Saguchi K, Hashimoto K, etal |title=Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 3 |pages= 296–8 |year= 1995 |pmid= 7587397 |doi=10.1159/000134130 }}
*{{cite journal | author=Choi-Miura NH, Sano Y, Oda E, ''et al.'' |title=Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. |journal=J. Biochem. |volume=117 |issue= 2 |pages= 400-7 |year= 1995 |pmid= 7541790 |doi=  }}
*{{cite journal   |vauthors=Saguchi K, Tobe T, Hashimoto K, etal |title=Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. |journal=J. Biochem. |volume=117 |issue= 1 |pages= 14–8 |year= 1995 |pmid= 7775381 |doi=  }}
*{{cite journal | author=Tobe T, Saguchi K, Hashimoto K, ''et al.'' |title=Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21-->p14. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 3 |pages= 296-8 |year= 1995 |pmid= 7587397 |doi=  }}
*{{cite journal   |vauthors=Saguchi K, Tobe T, Hashimoto K, etal |title=Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). |journal=J. Biochem. |volume=119 |issue= 5 |pages= 898–905 |year= 1997 |pmid= 8797089 |doi=  10.1093/oxfordjournals.jbchem.a021327}}
*{{cite journal | author=Saguchi K, Tobe T, Hashimoto K, ''et al.'' |title=Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. |journal=J. Biochem. |volume=117 |issue= 1 |pages= 14-8 |year= 1995 |pmid= 7775381 |doi=  }}
*{{cite journal   |vauthors=Jean L, Smih F, Olivier E, etal |title=Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. |journal=Genomics |volume=41 |issue= 1 |pages= 139–40 |year= 1997 |pmid= 9126497 |doi= 10.1006/geno.1997.4612 }}
*{{cite journal | author=Nishimura H, Kakizaki I, Muta T, ''et al.'' |title=cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. |journal=FEBS Lett. |volume=357 |issue= 2 |pages= 207-11 |year= 1995 |pmid= 7805892 |doi=  }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809–19 |year= 1998 |pmid= 9756925 |doi=10.1074/jbc.273.41.26809 }}
*{{cite journal  | author=Saguchi K, Tobe T, Hashimoto K, ''et al.'' |title=Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). |journal=J. Biochem. |volume=119 |issue= 5 |pages= 898-905 |year= 1997 |pmid= 8797089 |doi=  }}
*{{cite journal   |vauthors=Tozaki T, Choi-Miura NH, Taniyama M, etal |title=SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method. |journal=BMC Med. Genet. |volume=3|pages= 6 |year= 2003 |pmid= 12147176 |doi=10.1186/1471-2350-3-6  | pmc=117798 }}
*{{cite journal | author=Jean L, Smih F, Olivier E, ''et al.'' |title=Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. |journal=Genomics |volume=41 |issue= 1 |pages= 139-40 |year= 1997 |pmid= 9126497 |doi= 10.1006/geno.1997.4612 }}
*{{cite journal  |vauthors=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 }}
*{{cite journal | author=Soury E, Olivier E, Daveau M, ''et al.'' |title=The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 522-30 |year= 1998 |pmid= 9480842 |doi= 10.1006/bbrc.1998.8128 }}
*{{cite journal   |vauthors=Fujita Y, Ezura Y, Emi M, etal |title=Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. |journal=J. Hum. Genet. |volume=49 |issue= 1 |pages= 24–8 |year= 2004 |pmid= 14661079 |doi= 10.1007/s10038-003-0101-8 }}
*{{cite journal  | author=Diarra-Mehrpour M, Sarafan N, Bourguignon J, ''et al.'' |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809-19 |year= 1998 |pmid= 9756925 |doi=  }}
*{{cite journal   |vauthors=Anderson NL, Polanski M, Pieper R, etal |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Tozaki T, Choi-Miura NH, Taniyama M, ''et al.'' |title=SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method. |journal=BMC Med. Genet. |volume=3 |issue=  |pages= 6 |year= 2003 |pmid= 12147176 |doi=  }}
*{{cite journal  |vauthors=Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR |title=Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. |journal=Proteomics |volume=4 |issue= 2 |pages= 454–65 |year= 2004 |pmid= 14760718 |doi= 10.1002/pmic.200300556 }}
*{{cite journal  | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660-6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 }}
*{{cite journal   |vauthors=Kroczynska B, King-Simmons L, Alloza L, etal |title=BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 3 |pages= 1467–77 |year= 2006 |pmid= 16271702 |doi= 10.1016/j.bbrc.2005.10.101 }}
*{{cite journal | author=Fujita Y, Ezura Y, Emi M, ''et al.'' |title=Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. |journal=J. Hum. Genet. |volume=49 |issue= 1 |pages= 24-8 |year= 2004 |pmid= 14661079 |doi= 10.1007/s10038-003-0101-8 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal  | author=Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR |title=Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. |journal=Proteomics |volume=4 |issue= 2 |pages= 454-65 |year= 2004 |pmid= 14760718 |doi= 10.1002/pmic.200300556 }}
*{{cite journal | author=Kroczynska B, King-Simmons L, Alloza L, ''et al.'' |title=BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 3 |pages= 1467-77 |year= 2006 |pmid= 16271702 |doi= 10.1016/j.bbrc.2005.10.101 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:12, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.[1][2][3]

See also

References

  1. ↑ Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
  2. ↑ Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett. 357 (2): 207–11. doi:10.1016/0014-5793(94)01364-7. PMID 7805892.
  3. ↑ "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)".

Further reading


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