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{{Infobox_gene}}
'''ER lumen protein retaining receptor 2''' is a [[protein]] that in humans is encoded by the ''KDELR2'' [[gene]].<ref name="pmid1316805">{{cite journal |vauthors=Hsu VW, Shah N, Klausner RD | title = A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1 | journal = Cell | volume = 69 | issue = 4 | pages = 625–35 |date=Jun 1992 | pmid = 1316805 | pmc =  | doi =10.1016/0092-8674(92)90226-3  }}</ref><ref name="pmid1325562">{{cite journal |vauthors=Lewis MJ, Pelham HR | title = Sequence of a second human KDEL receptor | journal = J Mol Biol | volume = 226 | issue = 4 | pages = 913–6 |date=Oct 1992 | pmid = 1325562 | pmc =  | doi =10.1016/0022-2836(92)91039-R  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11014| accessdate = }}</ref>
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment.  Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, [[lysine|lys]]-[[aspartic acid|asp]]-[[glutamic acid|glu]]-[[Leucine|leu]] ([[KDEL (amino acid sequence)|KDEL]]) in animal cells and [[histidine|his]]-asp-glu-leu (HDEL) in ''[[Saccharomyces cerevisiae|S. cerevisiae]]''.  This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER.  In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.  Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.<ref name="entrez" />
==See also==
*[[KDELR1]]
*[[KDELR3]]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Pelham HR |title=The dynamic organisation of the secretory pathway |journal=Cell Struct. Funct. |volume=21 |issue= 5 |pages= 413–9 |year= 1997 |pmid= 9118249 |doi=10.1247/csf.21.413  }}
*{{cite journal  |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
*{{cite journal  |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=van der Vlies D, Pap EH, Post JA, etal |title=Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 825–30 |year= 2002 |pmid= 12071860 |doi= 10.1042/BJ20020618  | pmc=1222834 }}
*{{cite journal  |vauthors=Xu XR, Huang J, Xu ZG, etal |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398  | pmc=64988 }}
}}
{{refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
| HGNCid = 6305
| Symbol = KDELR2
| AltSymbols =; ELP-1; ERD2.2
| OMIM = 
| ECnumber = 
| Homologene = 38236
| MGIid = 
| GeneAtlas_image1 = PBB_GE_KDELR2_200699_at_tn.png
| GeneAtlas_image2 = PBB_GE_KDELR2_200698_at_tn.png
| GeneAtlas_image3 = PBB_GE_KDELR2_200700_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005046 |text = KDEL sequence binding}} {{GNF_GO|id=GO:0046923 |text = ER retention sequence binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006621 |text = protein retention in ER}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11014
    | Hs_Ensembl = ENSG00000136240
    | Hs_RefseqProtein = NP_006845
    | Hs_RefseqmRNA = NM_006854
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 6467933
    | Hs_GenLoc_end = 6490291
    | Hs_Uniprot = P33947
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2''', also known as '''KDELR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11014| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment.  Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae.  This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER.  In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.  Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.<ref name="entrez">{{cite web | title = Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11014| accessdate = }}</ref>
}}


==References==
{{gene-7-stub}}
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Pelham HR |title=The dynamic organisation of the secretory pathway. |journal=Cell Struct. Funct. |volume=21 |issue= 5 |pages= 413-9 |year= 1997 |pmid= 9118249 |doi=  }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=van der Vlies D, Pap EH, Post JA, ''et al.'' |title=Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 825-30 |year= 2002 |pmid= 12071860 |doi= 10.1042/BJ20020618 }}
*{{cite journal  | author=Xu XR, Huang J, Xu ZG, ''et al.'' |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089-94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 }}
*{{cite journal  | author=Lewis MJ, Pelham HR |title=Sequence of a second human KDEL receptor. |journal=J. Mol. Biol. |volume=226 |issue= 4 |pages= 913-6 |year= 1992 |pmid= 1325562 |doi=  }}
*{{cite journal  | author=Hsu VW, Shah N, Klausner RD |title=A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. |journal=Cell |volume=69 |issue= 4 |pages= 625-35 |year= 1992 |pmid= 1316805 |doi=  }}
}}
{{refend}}


{{protein-stub}}
[[Category:Endoplasmic reticulum resident proteins]]
{{WikiDoc Sources}}

Latest revision as of 15:51, 18 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.[1][2][3]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.[3]

See also

References

  1. ↑ Hsu VW, Shah N, Klausner RD (Jun 1992). "A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1". Cell. 69 (4): 625–35. doi:10.1016/0092-8674(92)90226-3. PMID 1316805.
  2. ↑ Lewis MJ, Pelham HR (Oct 1992). "Sequence of a second human KDEL receptor". J Mol Biol. 226 (4): 913–6. doi:10.1016/0022-2836(92)91039-R. PMID 1325562.
  3. ↑ 3.0 3.1 "Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2".

Further reading



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