KIF4A: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Chromosome-associated kinesin KIF4A''' is a [[protein]] that in humans is encoded by the ''KIF4A'' [[gene]].<ref name="pmid10773663">{{cite journal | vauthors = Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W | title = Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1-2 | pages = 41–2 | date = Jun 2000 | pmid = 10773663 | pmc =  | doi = 10.1159/000015482 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF4A kinesin family member 4A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24137| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kinesin family member 4A
| HGNCid = 13339
| Symbol = KIF4A
| AltSymbols =; FLJ12530; FLJ12655; FLJ14204; FLJ20631; HSA271784; KIF4; KIF4-G1
| OMIM = 300521
| ECnumber = 
| Homologene = 69022
| MGIid = 108389
| GeneAtlas_image1 = PBB_GE_KIF4A_218355_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0005876 |text = spindle microtubule}}
| Process = {{GNF_GO|id=GO:0006996 |text = organelle organization and biogenesis}} {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0008089 |text = anterograde axon cargo transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 24137
    | Hs_Ensembl = ENSG00000090889
    | Hs_RefseqProtein = NP_036442
    | Hs_RefseqmRNA = NM_012310
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 69426665
    | Hs_GenLoc_end = 69557407
    | Hs_Uniprot = O95239
    | Mm_EntrezGene = 16571
    | Mm_Ensembl = ENSMUSG00000034311
    | Mm_RefseqmRNA = XM_982929
    | Mm_RefseqProtein = XP_988023
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 96828456
    | Mm_GenLoc_end = 96929658
    | Mm_Uniprot = Q3UWH4
  }}
}}
'''Kinesin family member 4A''', also known as '''KIF4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF4A kinesin family member 4A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24137| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Kinesin]]s, such as KIF4A, are [[microtubule]]-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division (Zhu and Jiang, 2005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: KIF4A kinesin family member 4A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24137| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
KIF4A has been shown to [[Protein-protein interaction|interact]] with [[HMG20B]]<ref name=pmid12809554>{{cite journal | vauthors = Lee YM, Kim W | title = Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 | journal = The Biochemical Journal | volume = 374 | issue = Pt 2 | pages = 497–503 | date = Sep 2003 | pmid = 12809554 | pmc = 1223617 | doi = 10.1042/BJ20030452 }}</ref> and [[DNMT3B]].<ref name=pmid15148359>{{cite journal | vauthors = Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD | title = Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery | journal = Nucleic Acids Research | volume = 32 | issue = 9 | pages = 2716–29 | year = 2004 | pmid = 15148359 | pmc = 419596 | doi = 10.1093/nar/gkh589 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N | title = A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally | journal = The Journal of Cell Biology | volume = 127 | issue = 1 | pages = 187–201 | date = Oct 1994 | pmid = 7929562 | pmc = 2120182 | doi = 10.1083/jcb.127.1.187 }}
| citations =
* {{cite journal | vauthors = Yan RT, Wang SZ | title = Increased chromokinesin immunoreactivity in retinoblastoma cells | journal = Gene | volume = 189 | issue = 2 | pages = 263–7 | date = Apr 1997 | pmid = 9168136 | doi = 10.1016/S0378-1119(96)00860-8 }}
*{{cite journal | author=Sekine Y, Okada Y, Noda Y, ''et al.'' |title=A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 187-201 |year= 1994 |pmid= 7929562 |doi= }}
* {{cite journal | vauthors = Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, Goff SP, Morse HC | title = Cellular motor protein KIF-4 associates with retroviral Gag | journal = Journal of Virology | volume = 73 | issue = 12 | pages = 10508–13 | date = Dec 1999 | pmid = 10559369 | pmc = 113106 | doi =  }}
*{{cite journal | author=Yan RT, Wang SZ |title=Increased chromokinesin immunoreactivity in retinoblastoma cells. |journal=Gene |volume=189 |issue= 2 |pages= 263-7 |year= 1997 |pmid= 9168136 |doi= }}
* {{cite journal | vauthors = Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, Morse HC, Kim W | title = Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein | journal = Biochimica et Biophysica Acta | volume = 1493 | issue = 1-2 | pages = 219–24 | date = Sep 2000 | pmid = 10978527 | doi = 10.1016/s0167-4781(00)00151-2 }}
*{{cite journal | author=Tang Y, Winkler U, Freed EO, ''et al.'' |title=Cellular motor protein KIF-4 associates with retroviral Gag. |journal=J. Virol. |volume=73 |issue= 12 |pages= 10508-13 |year= 1999 |pmid= 10559369 |doi=  }}
* {{cite journal | vauthors = Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W | title = Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis | journal = The Biochemical Journal | volume = 360 | issue = Pt 3 | pages = 549–56 | date = Dec 2001 | pmid = 11736643 | pmc = 1222256 | doi = 10.1042/0264-6021:3600549 }}
*{{cite journal  | author=Ha MJ, Yoon J, Moon E, ''et al.'' |title=Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 41-2 |year= 2000 |pmid= 10773663 |doi=  }}
* {{cite journal | vauthors = Lee YM, Kim W | title = Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 | journal = The Biochemical Journal | volume = 374 | issue = Pt 2 | pages = 497–503 | date = Sep 2003 | pmid = 12809554 | pmc = 1223617 | doi = 10.1042/BJ20030452 }}
*{{cite journal | author=Oh S, Hahn H, Torrey TA, ''et al.'' |title=Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 219-24 |year= 2000 |pmid= 10978527 |doi= }}
* {{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = Sep 2003 | pmid = 12927788 | doi = 10.1016/S0006-291X(03)01486-4 }}
*{{cite journal | author=Lee YM, Lee S, Lee E, ''et al.'' |title=Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. |journal=Biochem. J. |volume=360 |issue= Pt 3 |pages= 549-56 |year= 2002 |pmid= 11736643 |doi=  }}
* {{cite journal | vauthors = Lee YM, Kim W | title = Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells | journal = Experimental & Molecular Medicine | volume = 36 | issue = 1 | pages = 93–7 | date = Feb 2004 | pmid = 15031677 | doi = 10.1038/emm.2004.13 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD | title = Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery | journal = Nucleic Acids Research | volume = 32 | issue = 9 | pages = 2716–29 | year = 2004 | pmid = 15148359 | pmc = 419596 | doi = 10.1093/nar/gkh589 }}
*{{cite journal | author=Lee YM, Kim W |title=Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. |journal=Biochem. J. |volume=374 |issue= Pt 2 |pages= 497-503 |year= 2003 |pmid= 12809554 |doi= 10.1042/BJ20030452 }}
* {{cite journal | vauthors = Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K | title = Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation | journal = The EMBO Journal | volume = 23 | issue = 16 | pages = 3237–48 | date = Aug 2004 | pmid = 15297875 | pmc = 514520 | doi = 10.1038/sj.emboj.7600347 }}
*{{cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793-801 |year= 2003 |pmid= 12927788 |doi= }}
* {{cite journal | vauthors = Mazumdar M, Sundareshan S, Misteli T | title = Human chromokinesin KIF4A functions in chromosome condensation and segregation | journal = The Journal of Cell Biology | volume = 166 | issue = 5 | pages = 613–20 | date = Aug 2004 | pmid = 15326200 | pmc = 2172419 | doi = 10.1083/jcb.200401142 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Zhu C, Jiang W | title = Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 2 | pages = 343–8 | date = Jan 2005 | pmid = 15625105 | pmc = 544298 | doi = 10.1073/pnas.0408438102 }}
*{{cite journal | author=Lee YM, Kim W |title=Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells. |journal=Exp. Mol. Med. |volume=36 |issue= 1 |pages= 93-7 |year= 2004 |pmid= 15031677 |doi= }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Geiman TM, Sankpal UT, Robertson AK, ''et al.'' |title=Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. |journal=Nucleic Acids Res. |volume=32 |issue= 9 |pages= 2716-29 |year= 2004 |pmid= 15148359 |doi= 10.1093/nar/gkh589 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Kurasawa Y, Earnshaw WC, Mochizuki Y, ''et al.'' |title=Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3237-48 |year= 2005 |pmid= 15297875 |doi= 10.1038/sj.emboj.7600347 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Mazumdar M, Sundareshan S, Misteli T |title=Human chromokinesin KIF4A functions in chromosome condensation and segregation. |journal=J. Cell Biol. |volume=166 |issue= 5 |pages= 613-20 |year= 2004 |pmid= 15326200 |doi= 10.1083/jcb.200401142 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhu C, Jiang W |title=Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 2 |pages= 343-8 |year= 2005 |pmid= 15625105 |doi= 10.1073/pnas.0408438102 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-X-stub}}

Latest revision as of 06:27, 2 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.[1][2]

Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[2]

Interactions

KIF4A has been shown to interact with HMG20B[3] and DNMT3B.[4]

References

  1. ↑ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–2. doi:10.1159/000015482. PMID 10773663.
  2. ↑ 2.0 2.1 "Entrez Gene: KIF4A kinesin family member 4A".
  3. ↑ Lee YM, Kim W (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  4. ↑ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=KIF4A&oldid=1423009"