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{{Infobox_gene}}
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'''Probable leucyl-tRNA synthetase, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''LARS2'' [[gene]].<ref name="pmid15123417">{{cite journal |vauthors=Sohm B, Sissler M, Park H, King MP, Florentz C | title = Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase | journal = J Mol Biol | volume = 339 | issue = 1 | pages = 17–29 |date=May 2004 | pmid = 15123417 | pmc =  | doi = 10.1016/j.jmb.2004.03.066 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Leucyl-tRNA synthetase 2, mitochondrial
| HGNCid = 17095
| Symbol = LARS2
| AltSymbols =; KIAA0028; LEURS; MGC26121
| OMIM = 604544
| ECnumber = 
| Homologene = 6526
| MGIid = 2142973
| GeneAtlas_image1 = PBB_GE_LARS2_204016_at_tn.png
| GeneAtlas_image2 = PBB_GE_LARS2_34764_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004823 |text = leucine-tRNA ligase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006429 |text = leucyl-tRNA aminoacylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23395
    | Hs_Ensembl = ENSG00000011376
    | Hs_RefseqProtein = NP_056155
    | Hs_RefseqmRNA = NM_015340
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 45405072
    | Hs_GenLoc_end = 45565332
    | Hs_Uniprot = Q15031
    | Mm_EntrezGene = 102436
    | Mm_Ensembl = ENSMUSG00000035202
    | Mm_RefseqmRNA = NM_153168
    | Mm_RefseqProtein = NP_694808
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 123215638
    | Mm_GenLoc_end = 123311362
    | Mm_Uniprot = Q14DP3
  }}
}}
'''Leucyl-tRNA synthetase 2, mitochondrial''', also known as '''LARS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.<ref name="entrez">{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}</ref>
| summary_text = This gene encodes a [[Aminoacyl tRNA synthetases, class I|class 1]] [[aminoacyl-tRNA synthetase]], mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.<ref name="entrez">{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Olsson P, Wennberg AL |title=[Midwife and research. Conference report] |journal=Jordemodern |volume=104 |issue= 11 |pages= 408-9, 404 |year= 1992 |pmid= 1684970 |doi=  }}
*{{cite journal  |vauthors=Olsson P, Wennberg AL |title=[Midwife and research. Conference report] |journal=Jordemodern |volume=104 |issue= 11 |pages= 408–9, 404 |year= 1992 |pmid= 1684970 |doi=  }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 }}
*{{cite journal | author=Szeles A, Yang Y, Sandlund AM, ''et al.'' |title=Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM. |journal=Genes Chromosomes Cancer |volume=20 |issue= 4 |pages= 329-36 |year= 1998 |pmid= 9408748 |doi=  }}
*{{cite journal   |vauthors=Szeles A, Yang Y, Sandlund AM, etal |title=Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM. |journal=Genes Chromosomes Cancer |volume=20 |issue= 4 |pages= 329–36 |year= 1998 |pmid= 9408748 |doi=10.1002/(SICI)1098-2264(199712)20:4<329::AID-GCC3>3.0.CO;2-3 }}
*{{cite journal | author=Kiss H, Kedra D, Yang Y, ''et al.'' |title=A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. |journal=Hum. Genet. |volume=105 |issue= 6 |pages= 552-9 |year= 2000 |pmid= 10647888 |doi=  }}
*{{cite journal   |vauthors=Kiss H, Kedra D, Yang Y, etal |title=A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. |journal=Hum. Genet. |volume=105 |issue= 6 |pages= 552–9 |year= 2000 |pmid= 10647888 |doi=10.1007/s004390051144 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Yao YN, Wang L, Wu XF, Wang ED |title=The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells. |journal=FEBS Lett. |volume=534 |issue= 1-3 |pages= 139-42 |year= 2004 |pmid= 12527375 |doi=  }}
*{{cite journal  |vauthors=Yao YN, Wang L, Wu XF, Wang ED |title=The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells. |journal=FEBS Lett. |volume=534 |issue= 1–3 |pages= 139–42 |year= 2004 |pmid= 12527375 |doi=10.1016/S0014-5793(02)03833-4 }}
*{{cite journal  | author=Park H, Davidson E, King MP |title=The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation. |journal=Biochemistry |volume=42 |issue= 4 |pages= 958-64 |year= 2003 |pmid= 12549915 |doi= 10.1021/bi026882r }}
*{{cite journal  |vauthors=Park H, Davidson E, King MP |title=The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation |journal=Biochemistry |volume=42 |issue= 4 |pages= 958–64 |year= 2003 |pmid= 12549915 |doi= 10.1021/bi026882r }}
*{{cite journal  | author=Yao YN, Wang L, Wu XF, Wang ED |title=Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli. |journal=Protein Expr. Purif. |volume=30 |issue= 1 |pages= 112-6 |year= 2004 |pmid= 12821328 |doi=  }}
*{{cite journal  |vauthors=Yao YN, Wang L, Wu XF, Wang ED |title=Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli |journal=Protein Expr. Purif. |volume=30 |issue= 1 |pages= 112–6 |year= 2004 |pmid= 12821328 |doi=10.1016/S1046-5928(03)00097-4  }}
*{{cite journal  | author=Sohm B, Sissler M, Park H, ''et al.'' |title=Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase. |journal=J. Mol. Biol. |volume=339 |issue= 1 |pages= 17-29 |year= 2004 |pmid= 15123417 |doi= 10.1016/j.jmb.2004.03.066 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Munakata K, Iwamoto K, Bundo M, Kato T |title=Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia |journal=Biol. Psychiatry |volume=57 |issue= 5 |pages= 525–32 |year= 2005 |pmid= 15737668 |doi= 10.1016/j.biopsych.2004.11.041 }}
*{{cite journal  | author=Munakata K, Iwamoto K, Bundo M, Kato T |title=Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. |journal=Biol. Psychiatry |volume=57 |issue= 5 |pages= 525-32 |year= 2005 |pmid= 15737668 |doi= 10.1016/j.biopsych.2004.11.041 }}
*{{cite journal   |vauthors='t Hart LM, Hansen T, Rietveld I, etal |title=Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene |journal=Diabetes |volume=54 |issue= 6 |pages= 1892–5 |year= 2005 |pmid= 15919814 |doi=10.2337/diabetes.54.6.1892 }}
*{{cite journal | author='t Hart LM, Hansen T, Rietveld I, ''et al.'' |title=Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. |journal=Diabetes |volume=54 |issue= 6 |pages= 1892-5 |year= 2005 |pmid= 15919814 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Biology of bipolar disorder]]
 
 
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Latest revision as of 07:48, 28 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene.[1][2]

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.[2]

References

  1. ↑ Sohm B, Sissler M, Park H, King MP, Florentz C (May 2004). "Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase". J Mol Biol. 339 (1): 17–29. doi:10.1016/j.jmb.2004.03.066. PMID 15123417.
  2. ↑ 2.0 2.1 "Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial".

Further reading


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