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{{Infobox_gene}}
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'''Linker for activation of T-cells family member 2''' is a [[protein]] that in humans is encoded by the ''LAT2'' [[gene]].<ref name="pmid8812460">{{cite journal |vauthors=Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC | title = Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients | journal = Genomics | volume = 36 | issue = 2 | pages = 328–36 |date=Jan 1997 | pmid = 8812460 | pmc = | doi = 10.1006/geno.1996.0469 }}</ref><ref name="pmid12514734">{{cite journal |vauthors=Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W | title = LAB: a new membrane-associated adaptor molecule in B cell activation | journal = Nat Immunol | volume = 4 | issue = 2 | pages = 117–23 |date=Jan 2003 | pmid = 12514734 | pmc =  | doi = 10.1038/ni882 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LAT2 linker for activation of T cells family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7462| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Linker for activation of T cells family, member 2
| HGNCid = 12749
| Symbol = LAT2
| AltSymbols =; HSPC046; LAB; NTAL; WBSCR15; WBSCR5; WSCR5
| OMIM = 605719
| ECnumber = 
| Homologene = 11297
| MGIid = 1926479
| GeneAtlas_image1 = PBB_GE_LAT2_221581_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}  
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}} {{GNF_GO|id=GO:0042113 |text = B cell activation}} {{GNF_GO|id=GO:0043303 |text = mast cell degranulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7462
    | Hs_Ensembl = ENSG00000086730
    | Hs_RefseqProtein = NP_071323
    | Hs_RefseqmRNA = NM_022040
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 73262211
    | Hs_GenLoc_end = 73282093
    | Hs_Uniprot = Q9GZY6
    | Mm_EntrezGene = 56743
    | Mm_Ensembl = ENSMUSG00000040751
    | Mm_RefseqmRNA = NM_020044
    | Mm_RefseqProtein = NP_064428
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 134884892
    | Mm_GenLoc_end = 134899650
    | Mm_Uniprot = Q9JHL0
  }}
}}
'''Linker for activation of T cells family, member 2''', also known as '''LAT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LAT2 linker for activation of T cells family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7462| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: LAT2 linker for activation of T cells family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7462| accessdate = }}</ref>
| summary_text = This gene is one of the contiguous genes at 7q11.23 commonly deleted in [[Williams syndrome]], a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function. |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119-22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001 }}
*{{cite journal  | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119–22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Pérez Jurado LA, Peoples R, Kaplan P, ''et al.'' |title=Molecular definition of the chromosome 7 deletion in Williams syndrome and parent-of-origin effects on growth. |journal=Am. J. Hum. Genet. |volume=59 |issue= 4 |pages= 781-92 |year= 1996 |pmid= 8808592 |doi=  }}
*{{cite journal  | author=Pérez Jurado LA |title=Molecular definition of the chromosome 7 deletion in Williams syndrome and parent-of-origin effects on growth |journal=Am. J. Hum. Genet. |volume=59 |issue= 4 |pages= 781–92 |year= 1996 |pmid= 8808592 |doi=  | pmc=1914804 |name-list-format=vanc| author2=Peoples R  | author3=Kaplan P  | display-authors=3  | last4=Hamel  | first4=BC  | last5=Francke  | first5=U  }}
*{{cite journal | author=Osborne LR, Martindale D, Scherer SW, ''et al.'' |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328-36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469 }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | author=Martindale DW |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23 |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=10.1007/s003350010166 |name-list-format=vanc| author2=Wilson MD | author3=Wang D  | display-authors=3  | last4=Burke  | first4=Robert D. | last5=Chen  | first5=Xianming  | last6=Duronio  | first6=Vincent  | last7=Koop  | first7=Ben F. }}
*{{cite journal | author=Martindale DW, Wilson MD, Wang D, ''et al.'' |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890-8 |year= 2000 |pmid= 11003705 |doi=  }}
*{{cite journal  | author=Zhang QH |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 |name-list-format=vanc| author2=Ye M  | author3=Wu XY  | display-authors=3  | last4=Ren  | first4=SX  | last5=Zhao  | first5=M  | last6=Zhao  | first6=CJ | last7=Fu  | first7=G  | last8=Shen  | first8=Y  | last9=Fan  | first9=HY  }}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal  |vauthors=Doyle JL, DeSilva U, Miller W, Green ED |title=Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 285–90 |year= 2001 |pmid= 11124535 |doi=10.1159/000056790  }}
*{{cite journal | author=Doyle JL, DeSilva U, Miller W, Green ED |title=Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3-4 |pages= 285-90 |year= 2001 |pmid= 11124535 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Brdicka T |title=Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling |journal=J. Exp. Med. |volume=196 |issue= 12 |pages= 1617–26 |year= 2003 |pmid= 12486104 |doi=10.1084/jem.20021405  | pmc=2196071 |name-list-format=vanc| author2=Imrich M  | author3=Angelisová P  | display-authors=3  | last4=Brdickova  | first4=N.  | last5=Horvath  | first5=O.  | last6=Spicka  | first6=J.  | last7=Hilgert  | first7=I.  | last8=Luskova  | first8=P.  | last9=Draber  | first9=P. }}
*{{cite journal | author=Brdicka T, Imrich M, Angelisová P, ''et al.'' |title=Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. |journal=J. Exp. Med. |volume=196 |issue= 12 |pages= 1617-26 |year= 2003 |pmid= 12486104 |doi=  }}
*{{cite journal  | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-format=vanc| author2=Fulton RS  | author3=Fulton LA  | display-authors=3  | last4=Graves  | first4=Tina A. | last5=Pepin  | first5=Kymberlie H. | last6=Wagner-Mcpherson  | first6=Caryn  | last7=Layman  | first7=Dan  | last8=Maas  | first8=Jason  | last9=Jaeger  | first9=Sara }}
*{{cite journal  | author=Janssen E, Zhu M, Zhang W, ''et al.'' |title=LAB: a new membrane-associated adaptor molecule in B cell activation. |journal=Nat. Immunol. |volume=4 |issue= 2 |pages= 117-23 |year= 2003 |pmid= 12514734 |doi= 10.1038/ni882 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  |vauthors=Koonpaew S, Janssen E, Zhu M, Zhang W |title=The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11229–35 |year= 2004 |pmid= 14722116 |doi= 10.1074/jbc.M311394200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Tkaczyk C |title=NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation |journal=Blood |volume=104 |issue= 1 |pages= 207–14 |year= 2004 |pmid= 15010370 |doi= 10.1182/blood-2003-08-2769  |name-list-format=vanc| author2=Horejsi V  | author3=Iwaki S  | display-authors=3  | last4=Draber  | first4=P  | last5=Samelson  | first5=LE  | last6=Satterthwaite  | first6=AB  | last7=Nahm  | first7=DH  | last8=Metcalfe  | first8=DD  | last9=Gilfillan  | first9=AM }}
*{{cite journal  | author=Koonpaew S, Janssen E, Zhu M, Zhang W |title=The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11229-35 |year= 2004 |pmid= 14722116 |doi= 10.1074/jbc.M311394200 }}
*{{cite journal  |vauthors=Janssen E, Zhu M, Craven B, Zhang W |title=Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6810–9 |year= 2004 |pmid= 15153499 |doi=  10.4049/jimmunol.172.11.6810}}
*{{cite journal | author=Tkaczyk C, Horejsi V, Iwaki S, ''et al.'' |title=NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. |journal=Blood |volume=104 |issue= 1 |pages= 207-14 |year= 2004 |pmid= 15010370 |doi= 10.1182/blood-2003-08-2769 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Janssen E, Zhu M, Craven B, Zhang W |title=Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6810-9 |year= 2004 |pmid= 15153499 |doi=  }}
*{{cite journal  | author=Tedoldi S |title=Transmembrane adaptor molecules: a new category of lymphoid-cell markers |journal=Blood |volume=107 |issue= 1 |pages= 213–21 |year= 2006 |pmid= 16160011 |doi= 10.1182/blood-2005-06-2273  |name-list-format=vanc| author2=Paterson JC  | author3=Hansmann ML  | display-authors=3  | last4=Natkunam  | first4=Y  | last5=Rüdiger  | first5=T  | last6=Angelisova  | first6=P  | last7=Du  | first7=MQ  | last8=Roberton  | first8=H  | last9=Roncador  | first9=G }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal | author=Tedoldi S, Paterson JC, Hansmann ML, ''et al.'' |title=Transmembrane adaptor molecules: a new category of lymphoid-cell markers. |journal=Blood |volume=107 |issue= 1 |pages= 213-21 |year= 2006 |pmid= 16160011 |doi= 10.1182/blood-2005-06-2273 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:35, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.[1][2][3]

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.[3]

References

  1. ↑ Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.
  2. ↑ Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W (Jan 2003). "LAB: a new membrane-associated adaptor molecule in B cell activation". Nat Immunol. 4 (2): 117–23. doi:10.1038/ni882. PMID 12514734.
  3. ↑ 3.0 3.1 "Entrez Gene: LAT2 linker for activation of T cells family, member 2".

Further reading



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