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{{Infobox_gene}}
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'''Leupaxin''' is a [[protein]] that in humans is encoded by the ''LPXN'' [[gene]].<ref name="pmid9565592">{{cite journal |vauthors=Lipsky BP, Beals CR, Staunton DE | title = Leupaxin is a novel LIM domain protein that forms a complex with PYK2 | journal = J Biol Chem | volume = 273 | issue = 19 | pages = 11709–13 |date=Jun 1998 | pmid = 9565592 | pmc =  | doi =10.1074/jbc.273.19.11709 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LPXN leupaxin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9404| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_LPXN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x3h.
| PDB = {{PDB2|1x3h}}
| Name = Leupaxin
| HGNCid = 14061
| Symbol = LPXN
| AltSymbols =; LDPL
| OMIM = 605390
| ECnumber = 
| Homologene = 3536
| MGIid = 2147677
| GeneAtlas_image1 = PBB_GE_LPXN_216250_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9404
    | Hs_Ensembl = ENSG00000110031
    | Hs_RefseqProtein = NP_004802
    | Hs_RefseqmRNA = NM_004811
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 58050925
    | Hs_GenLoc_end = 58099910
    | Hs_Uniprot = O60711
    | Mm_EntrezGene = 107321
    | Mm_Ensembl = ENSMUSG00000024696
    | Mm_RefseqmRNA = NM_134152
    | Mm_RefseqProtein = NP_598913
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 12863212
    | Mm_GenLoc_end = 12900826
    | Mm_Uniprot = Q8R355
  }}
}}
'''Leupaxin''', also known as '''LPXN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LPXN leupaxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9404| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.<ref name="entrez">{{cite web | title = Entrez Gene: LPXN leupaxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9404| accessdate = }}</ref>
| summary_text = The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chew V, Lam KP |title=Leupaxin negatively regulates B cell receptor signaling. |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27181-91 |year= 2007 |pmid= 17640867 |doi= 10.1074/jbc.M704625200 }}
*{{cite journal  |vauthors=Chew V, Lam KP |title=Leupaxin negatively regulates B cell receptor signaling. |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27181–91 |year= 2007 |pmid= 17640867 |doi= 10.1074/jbc.M704625200 }}
*{{cite journal  | author=Sahu SN, Nunez S, Bai G, Gupta A |title=Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 6 |pages= C2288-96 |year= 2007 |pmid= 17329398 |doi= 10.1152/ajpcell.00503.2006 }}
*{{cite journal  |vauthors=Sahu SN, Nunez S, Bai G, Gupta A |title=Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 6 |pages= C2288–96 |year= 2007 |pmid= 17329398 |doi= 10.1152/ajpcell.00503.2006 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Tao WA, Wollscheid B, O'Brien R, ''et al.'' |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591-8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal   |vauthors=Tao WA, Wollscheid B, O'Brien R, etal |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal  | author=Watanabe N, Amano N, Ishizuka H, Mashima K |title=Leupaxin binds to PEST domain tyrosine phosphatase PEP. |journal=Mol. Cell. Biochem. |volume=269 |issue= 1-2 |pages= 13-7 |year= 2005 |pmid= 15786712 |doi=  }}
*{{cite journal  |vauthors=Watanabe N, Amano N, Ishizuka H, Mashima K |title=Leupaxin binds to PEST domain tyrosine phosphatase PEP. |journal=Mol. Cell. Biochem. |volume=269 |issue= 1-2 |pages= 13–7 |year= 2005 |pmid= 15786712 |doi=10.1007/s11010-005-2149-6 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Gupta A, Lee BS, Khadeer MA, ''et al.'' |title=Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. |journal=J. Bone Miner. Res. |volume=18 |issue= 4 |pages= 669-85 |year= 2003 |pmid= 12674328 |doi=  }}
*{{cite journal   |vauthors=Gupta A, Lee BS, Khadeer MA, etal |title=Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. |journal=J. Bone Miner. Res. |volume=18 |issue= 4 |pages= 669–85 |year= 2003 |pmid= 12674328 |doi=10.1359/jbmr.2003.18.4.669 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Liu S, Thomas SM, Woodside DG, ''et al.'' |title=Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. |journal=Nature |volume=402 |issue= 6762 |pages= 676-81 |year= 2000 |pmid= 10604475 |doi= 10.1038/45264 }}
*{{cite journal   |vauthors=Liu S, Thomas SM, Woodside DG, etal |title=Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. |journal=Nature |volume=402 |issue= 6762 |pages= 676–81 |year= 2000 |pmid= 10604475 |doi= 10.1038/45264 }}
*{{cite journal | author=Lipsky BP, Beals CR, Staunton DE |title=Leupaxin is a novel LIM domain protein that forms a complex with PYK2. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11709-13 |year= 1998 |pmid= 9565592 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9404}}
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Latest revision as of 18:05, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leupaxin is a protein that in humans is encoded by the LPXN gene.[1][2]

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.[2]

References

  1. ↑ Lipsky BP, Beals CR, Staunton DE (Jun 1998). "Leupaxin is a novel LIM domain protein that forms a complex with PYK2". J Biol Chem. 273 (19): 11709–13. doi:10.1074/jbc.273.19.11709. PMID 9565592.
  2. ↑ 2.0 2.1 "Entrez Gene: LPXN leupaxin".

Further reading



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