LRRC4: Difference between revisions

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{{Infobox_gene}}
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'''Leucine-rich repeat-containing protein 4''' is a [[protein]] that in humans is encoded by the ''LRRC4'' [[gene]].<ref name="pmid12969517">{{cite journal |vauthors=Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY | title = Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251 | journal = Ai Zheng | volume = 22 | issue = 9 | pages = 897–902 |date=Sep 2003 | pmid = 12969517 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LRRC4 leucine rich repeat containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64101| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_LRRC4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dl9.
| PDB = {{PDB2|2dl9}}
| Name = Leucine rich repeat containing 4
| HGNCid = 15586
| Symbol = LRRC4
| AltSymbols =; MGC133342; MGC133343; NAG14
| OMIM = 610486
| ECnumber = 
| Homologene = 36403
| MGIid = 2182081
| GeneAtlas_image1 = PBB_GE_LRRC4_gnf1h00399_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64101
    | Hs_Ensembl = ENSG00000128594
    | Hs_RefseqProtein = NP_071426
    | Hs_RefseqmRNA = NM_022143
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 127454360
    | Hs_GenLoc_end = 127458238
    | Hs_Uniprot = Q9HBW1
    | Mm_EntrezGene = 192198
    | Mm_Ensembl = ENSMUSG00000049939
    | Mm_RefseqmRNA = NM_138682
    | Mm_RefseqProtein = NP_619623
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 28779666
    | Mm_GenLoc_end = 28781624
    | Mm_Uniprot = Q149E5
  }}
}}
'''Leucine rich repeat containing 4''', also known as '''LRRC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRRC4 leucine rich repeat containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64101| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.<ref name="entrez">{{cite web | title = Entrez Gene: LRRC4 leucine rich repeat containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64101| accessdate = }}</ref>
| summary_text = This gene is significantly downregulated in primary [[brain tumor]]s. The exact function of the protein encoded by this gene is unknown.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Nakashiba T, Ikeda T, Nishimura S, ''et al.'' |title=Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. |journal=J. Neurosci. |volume=20 |issue= 17 |pages= 6540-50 |year= 2000 |pmid= 10964959 |doi=  }}
*{{cite journal   |vauthors=Nakashiba T, Ikeda T, Nishimura S, etal |title=Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. |journal=J. Neurosci. |volume=20 |issue= 17 |pages= 6540–50 |year= 2000 |pmid= 10964959 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Wang JR, Li XL, Fan SQ, ''et al.'' |title=Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251. |journal=Ai Zheng |volume=22 |issue= 9 |pages= 897-902 |year= 2004 |pmid= 12969517 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  |vauthors=Lin JC, Ho WH, Gurney A, Rosenthal A |title=The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. |journal=Nat. Neurosci. |volume=6 |issue= 12 |pages= 1270–6 |year= 2004 |pmid= 14595443 |doi= 10.1038/nn1148 }}
*{{cite journal  | author=Lin JC, Ho WH, Gurney A, Rosenthal A |title=The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. |journal=Nat. Neurosci. |volume=6 |issue= 12 |pages= 1270-6 |year= 2004 |pmid= 14595443 |doi= 10.1038/nn1148 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Zhang Q, Wang J, Fan S, etal |title=Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3674–82 |year= 2005 |pmid= 15967442 |doi= 10.1016/j.febslet.2005.05.058 }}
*{{cite journal | author=Zhang Q, Wang J, Fan S, ''et al.'' |title=Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3674-82 |year= 2005 |pmid= 15967442 |doi= 10.1016/j.febslet.2005.05.058 }}
*{{cite journal   |vauthors=Zhang QH, Wang LL, Cao L, etal |title=Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 8 |pages= 532–40 |year= 2005 |pmid= 16077900 |doi=10.1111/j.1745-7270.2005.00079.x }}
*{{cite journal | author=Zhang QH, Wang LL, Cao L, ''et al.'' |title=Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 8 |pages= 532-40 |year= 2005 |pmid= 16077900 |doi=  }}
*{{cite journal   |vauthors=Fan SQ, Wang JR, Huang H, etal |title=[Function of a novel brain-specific gene LRRC4] |journal=Zhonghua Zhong Liu Za Zhi |volume=27 |issue= 7 |pages= 393–6 |year= 2007 |pmid= 16188120 |doi=  }}
*{{cite journal | author=Fan SQ, Wang JR, Huang H, ''et al.'' |title=[Function of a novel brain-specific gene LRRC4] |journal=Zhonghua Zhong Liu Za Zhi |volume=27 |issue= 7 |pages= 393-6 |year= 2007 |pmid= 16188120 |doi=  }}
*{{cite journal   |vauthors=Zhang QH, Wu MH, Wang LL, etal |title=Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 10 |pages= 680–7 |year= 2005 |pmid= 16215635 |doi=10.1111/j.1745-7270.2005.00100.x }}
*{{cite journal | author=Zhang QH, Wu MH, Wang LL, ''et al.'' |title=Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 10 |pages= 680-7 |year= 2005 |pmid= 16215635 |doi=  }}
*{{cite journal   |vauthors=Wu M, Huang C, Gan K, etal |title=LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 8 |pages= 3534–42 |year= 2006 |pmid= 16723503 |doi= 10.1091/mbc.E05-11-1082 | pmc=1525233 }}
*{{cite journal | author=Wu M, Huang C, Gan K, ''et al.'' |title=LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 8 |pages= 3534-42 |year= 2006 |pmid= 16723503 |doi= 10.1091/mbc.E05-11-1082 }}
*{{cite journal   |vauthors=Wu M, Gan K, Huang C, etal |title=LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. |journal=J. Neurooncol. |volume=80 |issue= 2 |pages= 133–42 |year= 2007 |pmid= 16941076 |doi= 10.1007/s11060-006-9173-6 }}
*{{cite journal | author=Wu M, Gan K, Huang C, ''et al.'' |title=LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. |journal=J. Neurooncol. |volume=80 |issue= 2 |pages= 133-42 |year= 2007 |pmid= 16941076 |doi= 10.1007/s11060-006-9173-6 }}
*{{cite journal   |vauthors=Wu M, Huang C, Li X, etal |title=LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. |journal=J. Cell. Physiol. |volume=214 |issue= 1 |pages= 65–74 |year= 2007 |pmid= 17541939 |doi= 10.1002/jcp.21163 }}
*{{cite journal | author=Wu M, Huang C, Li X, ''et al.'' |title=LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. |journal=J. Cell. Physiol. |volume=214 |issue= 1 |pages= 65-74 |year= 2007 |pmid= 17541939 |doi= 10.1002/jcp.21163 }}
}}
}}
{{refend}}
{{refend}}
[[category:LRR proteins]]
{{PDB Gallery|geneid=64101}}
 
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[[Category:LRR proteins]]
 


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Latest revision as of 18:08, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.[1][2]

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.[2]

References

  1. ↑ Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY (Sep 2003). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". Ai Zheng. 22 (9): 897–902. PMID 12969517.
  2. ↑ 2.0 2.1 "Entrez Gene: LRRC4 leucine rich repeat containing 4".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=LRRC4&oldid=1421771"