MAD2L1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Mitotic spindle assembly checkpoint protein MAD2A''' is a [[protein]] that in humans is encoded by the ''MAD2L1'' [[gene]].<ref name="pmid8824189">{{cite journal | vauthors = Li Y, Benezra R | title = Identification of a human mitotic checkpoint gene: hsMAD2 | journal = Science | volume = 274 | issue = 5285 | pages = 246–8  | date = October 1996 | pmid = 8824189 | pmc =  | doi = 10.1126/science.274.5285.246 }}</ref><ref name="pmid9345911">{{cite journal | vauthors = Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T | title = Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 78 | issue = 1 | pages = 63–4  | date = November 1997 | pmid = 9345911 | pmc = | doi = 10.1159/000134631 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4085| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAD2L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1duj.
| PDB = {{PDB2|1duj}}, {{PDB2|1go4}}, {{PDB2|1klq}}, {{PDB2|1s2h}}
| Name = MAD2 mitotic arrest deficient-like 1 (yeast)
| HGNCid = 6763
| Symbol = MAD2L1
| AltSymbols =; HSMAD2; MAD2
| OMIM = 601467
| ECnumber = 
| Homologene = 1768
| MGIid = 1860374
| GeneAtlas_image1 = PBB_GE_MAD2L1_203362_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005816 |text = spindle pole body}}
| Process = {{GNF_GO|id=GO:0000070 |text = mitotic sister chromatid segregation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007094 |text = mitotic cell cycle spindle assembly checkpoint}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4085
    | Hs_Ensembl = ENSG00000164109
    | Hs_RefseqProtein = NP_002349
    | Hs_RefseqmRNA = NM_002358
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 121200029
    | Hs_GenLoc_end = 121207411
    | Hs_Uniprot = Q13257
    | Mm_EntrezGene = 56150
    | Mm_Ensembl = ENSMUSG00000029910
    | Mm_RefseqmRNA = NM_019499
    | Mm_RefseqProtein = NP_062372
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 66465046
    | Mm_GenLoc_end = 66470571
    | Mm_Uniprot = Q3TV93
  }}
}}
'''MAD2 mitotic arrest deficient-like 1 (yeast)''', also known as '''MAD2L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4085| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.  MAD2L1 is related to the MAD2L2 gene located on chromosome 1.  A MAD2 pseudogene has been mapped to chromosome 14.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.  MAD2L1 is related to the MAD2L2 gene located on chromosome 1.  A MAD2 pseudogene has been mapped to chromosome 14.<ref name="entrez">{{cite web | title = Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4085| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAD2L1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ADAM17]],<ref name = pmid10527948>{{cite journal | vauthors = Nelson KK, Schlöndorff J, Blobel CP | title = Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta | journal = Biochem. J. | volume = 343 | issue =  3| pages = 673–80  | date = November 1999 | pmid = 10527948 | pmc = 1220601 | doi =  10.1042/0264-6021:3430673}}</ref><ref name = pmid11741929>{{cite journal | vauthors = Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR | title = Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 4999–5007  | date = February 2002 | pmid = 11741929 | doi = 10.1074/jbc.M107430200 }}</ref>
* [[BUB1B]],<ref name = pmid11535616>{{cite journal | vauthors = Sudakin V, Chan GK, Yen TJ | title = Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 | journal = J. Cell Biol. | volume = 154 | issue = 5 | pages = 925–36  | date = September 2001 | pmid = 11535616 | pmc = 2196190 | doi = 10.1083/jcb.200102093 }}</ref>
* [[CDC20]],<ref name = pmid11438673>{{cite journal | vauthors = Zhang Y, Lees E | title = Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation | journal = Mol. Cell. Biol. | volume = 21 | issue = 15 | pages = 5190–9  | date = August 2001 | pmid = 11438673 | pmc = 87243 | doi = 10.1128/MCB.21.15.5190-5199.2001 }}</ref><ref name = pmid14607335>{{cite journal | vauthors = Sihn CR, Suh EJ, Lee KH, Kim TY, Kim SH | title = p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells | journal = Cancer Lett. | volume = 201 | issue = 2 | pages = 203–10  | date = November 2003 | pmid = 14607335 | doi =  10.1016/s0304-3835(03)00465-8}}</ref><ref name = pmid10700282>{{cite journal | vauthors = Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G | title = Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 | journal = Nat. Struct. Biol. | volume = 7 | issue = 3 | pages = 224–9  | date = March 2000 | pmid = 10700282 | doi = 10.1038/73338 }}</ref><ref name = pmid11707408>{{cite journal | vauthors = Sironi L, Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A | title = Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint | journal = EMBO J. | volume = 20 | issue = 22 | pages = 6371–82  | date = November 2001 | pmid = 11707408 | pmc = 125308 | doi = 10.1093/emboj/20.22.6371 }}</ref><ref name = pmid14561775>{{cite journal | vauthors = D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D | title = The spindle checkpoint requires cyclin-dependent kinase activity | journal = Genes Dev. | volume = 17 | issue = 20 | pages = 2520–5  | date = October 2003 | pmid = 14561775 | pmc = 218146 | doi = 10.1101/gad.267603 }}</ref><ref name = pmid12196507>{{cite journal | vauthors = Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ | title = Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells | journal = J. Cell Biol. | volume = 158 | issue = 5 | pages = 841–7  | date = September 2002 | pmid = 12196507 | pmc = 2173153 | doi = 10.1083/jcb.200201135 }}</ref><ref name = pmid9736712>{{cite journal | vauthors = Wassmann K, Benezra R | title = Mad2 transiently associates with an APC/p55Cdc complex during mitosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11193–8  | date = September 1998 | pmid = 9736712 | pmc = 21618 | doi =  10.1073/pnas.95.19.11193}}</ref><ref name = pmid9628895>{{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = J. Cell Biol. | volume = 141 | issue = 6 | pages = 1393–406  | date = June 1998 | pmid = 9628895 | pmc = 2132789 | doi =  10.1083/jcb.141.6.1393}}</ref><ref name = pmid9637688>{{cite journal | vauthors = Fang G, Yu H, Kirschner MW | title = The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation | journal = Genes Dev. | volume = 12 | issue = 12 | pages = 1871–83  | date = June 1998 | pmid = 9637688 | pmc = 316912 | doi =  10.1101/gad.12.12.1871}}</ref><ref name = pmid11274370>{{cite journal | vauthors = Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL | title = Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 8 | pages = 4492–7  | date = April 2001 | pmid = 11274370 | pmc = 31862 | doi = 10.1073/pnas.081076898 }}</ref><ref name = pmid18997788>{{cite journal | vauthors = Nilsson J, Yekezare M, Minshull J, Pines J | title = The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | journal = Nat. Cell Biol. | volume = 10 | issue = 12 | pages = 1411–20  | date = December 2008 | pmid = 18997788 | pmc = 2635557 | doi = 10.1038/ncb1799 }}</ref><ref name = pmid18592005>{{cite journal | vauthors = Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM | title = Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint | journal = Neoplasia | volume = 10 | issue = 7 | pages = 643–52  | date = July 2008 | pmid = 18592005 | pmc = 2435002 | doi =  10.1593/neo.08176}}</ref>
* [[CDC27]]<ref name = pmid9736712/><ref name = pmid9628895/> and
* [[Estrogen receptor beta]],<ref name = pmid10706629>{{cite journal | vauthors = Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME | title = Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 6 | pages = 2836–9  | date = March 2000 | pmid = 10706629 | pmc = 16016 | doi = 10.1073/pnas.050580997 }}</ref>
* [[MAD2L2]],<ref name = pmid10660610>{{cite journal | vauthors = Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R | title = A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4391–7  | date = February 2000 | pmid = 10660610 | doi =  10.1074/jbc.275.6.4391}}</ref>
* [[Mad1]],<ref name = pmid11707408/><ref name = pmid10660610/><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> and
* [[Ubiquitin D|UBD]].<ref name = pmid10200259>{{cite journal | vauthors = Liu YC, Pan J, Zhang C, Fan W, Collinge M, Bender JR, Weissman SM | title = A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 8 | pages = 4313–8  | date = April 1999 | pmid = 10200259 | pmc = 16329 | doi =  10.1073/pnas.96.8.4313}}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = O'Neill TJ, Zhu Y, Gustafson TA | title = Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation | journal = J. Biol. Chem. | volume = 272 | issue = 15 | pages = 10035–40 | year = 1997 | pmid = 9092546 | doi = 10.1074/jbc.272.15.10035 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Li Y, Benezra R |title=Identification of a human mitotic checkpoint gene: hsMAD2. |journal=Science |volume=274 |issue= 5285 |pages= 246-8 |year= 1996 |pmid= 8824189 |doi= }}
* {{cite journal | vauthors = Jin DY, Spencer F, Jeang KT | title = Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 | journal = Cell | volume = 93 | issue = 1 | pages = 81–91 | year = 1998 | pmid = 9546394 | doi = 10.1016/S0092-8674(00)81148-4 }}
*{{cite journal | author=O'Neill TJ, Zhu Y, Gustafson TA |title=Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10035-40 |year= 1997 |pmid= 9092546 |doi= }}
* {{cite journal | vauthors = Krishnan R, Goodman B, Jin DY, Jeang KT, Collins C, Stetten G, Spencer F | title = Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27 | journal = Genomics | volume = 49 | issue = 3 | pages = 475–8 | year = 1998 | pmid = 9615237 | doi = 10.1006/geno.1998.5233 }}
*{{cite journal | author=Xu L, Deng HX, Yang Y, ''et al.'' |title=Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 1 |pages= 63-4 |year= 1997 |pmid= 9345911 |doi= }}
* {{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = J. Cell Biol. | volume = 141 | issue = 6 | pages = 1393–406 | year = 1998 | pmid = 9628895 | pmc = 2132789 | doi = 10.1083/jcb.141.6.1393 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Fang G, Yu H, Kirschner MW | title = The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation | journal = Genes Dev. | volume = 12 | issue = 12 | pages = 1871–83 | year = 1998 | pmid = 9637688 | pmc = 316912 | doi = 10.1101/gad.12.12.1871 }}
*{{cite journal | author=Jin DY, Spencer F, Jeang KT |title=Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. |journal=Cell |volume=93 |issue= 1 |pages= 81-91 |year= 1998 |pmid= 9546394 |doi= }}
* {{cite journal | vauthors = Wassmann K, Benezra R | title = Mad2 transiently associates with an APC/p55Cdc complex during mitosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11193–8 | year = 1998 | pmid = 9736712 | pmc = 21618 | doi = 10.1073/pnas.95.19.11193 }}
*{{cite journal | author=Krishnan R, Goodman B, Jin DY, ''et al.'' |title=Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27. |journal=Genomics |volume=49 |issue= 3 |pages= 475-8 |year= 1998 |pmid= 9615237 |doi= 10.1006/geno.1998.5233 }}
* {{cite journal | vauthors = Liu YC, Pan J, Zhang C, Fan W, Collinge M, Bender JR, Weissman SM | title = A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 8 | pages = 4313–8 | year = 1999 | pmid = 10200259 | pmc = 16329 | doi = 10.1073/pnas.96.8.4313 }}
*{{cite journal | author=Kallio M, Weinstein J, Daum JR, ''et al.'' |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1393-406 |year= 1998 |pmid= 9628895 |doi= }}
* {{cite journal | vauthors = Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C | title = Characterization of MAD2B and other mitotic spindle checkpoint genes | journal = Genomics | volume = 58 | issue = 2 | pages = 181–7 | year = 1999 | pmid = 10366450 | doi = 10.1006/geno.1999.5831 }}
*{{cite journal | author=Fang G, Yu H, Kirschner MW |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1871-83 |year= 1998 |pmid= 9637688 |doi= }}
* {{cite journal | vauthors = Nelson KK, Schlöndorff J, Blobel CP | title = Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta | journal = Biochem. J. | volume = 343 | issue = 3| pages = 673–80 | year = 1999 | pmid = 10527948 | pmc = 1220601 | doi = 10.1042/0264-6021:3430673 }}
*{{cite journal | author=Wassmann K, Benezra R |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11193-8 |year= 1998 |pmid= 9736712 |doi= }}
* {{cite journal | vauthors = Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R | title = A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4391–7 | year = 2000 | pmid = 10660610 | doi = 10.1074/jbc.275.6.4391 }}
*{{cite journal | author=Liu YC, Pan J, Zhang C, ''et al.'' |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 8 |pages= 4313-8 |year= 1999 |pmid= 10200259 |doi= }}
* {{cite journal | vauthors = Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G | title = Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 | journal = Nat. Struct. Biol. | volume = 7 | issue = 3 | pages = 224–9 | year = 2000 | pmid = 10700282 | doi = 10.1038/73338 }}
*{{cite journal | author=Cahill DP, da Costa LT, Carson-Walter EB, ''et al.'' |title=Characterization of MAD2B and other mitotic spindle checkpoint genes. |journal=Genomics |volume=58 |issue= 2 |pages= 181-7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831 }}
* {{cite journal | vauthors = Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME | title = Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 6 | pages = 2836–9 | year = 2000 | pmid = 10706629 | pmc = 16016 | doi = 10.1073/pnas.050580997 }}
*{{cite journal | author=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 673-80 |year= 2000 |pmid= 10527948 |doi= }}
* {{cite journal | vauthors = Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA | title = Association between spindle assembly checkpoint expression and maternal age in human oocytes | journal = Mol. Hum. Reprod. | volume = 7 | issue = 1 | pages = 49–55 | year = 2001 | pmid = 11134360 | doi = 10.1093/molehr/7.1.49 }}
*{{cite journal | author=Murakumo Y, Roth T, Ishii H, ''et al.'' |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4391-7 |year= 2000 |pmid= 10660610 |doi= }}
* {{cite journal | vauthors = Campbell MS, Chan GK, Yen TJ | title = Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase | journal = J. Cell Sci. | volume = 114 | issue = Pt 5 | pages = 953–63 | year = 2001 | pmid = 11181178 | doi = }}
*{{cite journal | author=Luo X, Fang G, Coldiron M, ''et al.'' |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. |journal=Nat. Struct. Biol. |volume=7 |issue= 3 |pages= 224-9 |year= 2000 |pmid= 10700282 |doi= 10.1038/73338 }}
* {{cite journal | vauthors = Zhang Y, Lees E | title = Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation | journal = Mol. Cell. Biol. | volume = 21 | issue = 15 | pages = 5190–9 | year = 2001 | pmid = 11438673 | pmc = 87243 | doi = 10.1128/MCB.21.15.5190-5199.2001 }}
*{{cite journal | author=Poelzl G, Kasai Y, Mochizuki N, ''et al.'' |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2836-9 |year= 2000 |pmid= 10706629 |doi= 10.1073/pnas.050580997 }}
* {{cite journal | vauthors = Sudakin V, Chan GK, Yen TJ | title = Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 | journal = J. Cell Biol. | volume = 154 | issue = 5 | pages = 925–36 | year = 2001 | pmid = 11535616 | pmc = 2196190 | doi = 10.1083/jcb.200102093 }}
*{{cite journal | author=Steuerwald N, Cohen J, Herrera RJ, ''et al.'' |title=Association between spindle assembly checkpoint expression and maternal age in human oocytes. |journal=Mol. Hum. Reprod. |volume=7 |issue= 1 |pages= 49-55 |year= 2001 |pmid= 11134360 |doi= }}
*{{cite journal | author=Campbell MS, Chan GK, Yen TJ |title=Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 953-63 |year= 2001 |pmid= 11181178 |doi=  }}
*{{cite journal  | author=Zhang Y, Lees E |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5190-9 |year= 2001 |pmid= 11438673 |doi= 10.1128/MCB.21.15.5190-5199.2001 }}
*{{cite journal  | author=Sudakin V, Chan GK, Yen TJ |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. |journal=J. Cell Biol. |volume=154 |issue= 5 |pages= 925-36 |year= 2001 |pmid= 11535616 |doi= 10.1083/jcb.200102093 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:15, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[1][2][3]

Function

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.[3]

Interactions

MAD2L1 has been shown to interact with:

References

  1. ↑ Li Y, Benezra R (October 1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. doi:10.1126/science.274.5285.246. PMID 8824189.
  2. ↑ Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (November 1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet. Cell Genet. 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911.
  3. ↑ 3.0 3.1 "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)".
  4. ↑ Nelson KK, Schlöndorff J, Blobel CP (November 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 (3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
  5. ↑ Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR (February 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. 277 (7): 4999–5007. doi:10.1074/jbc.M107430200. PMID 11741929.
  6. ↑ Sudakin V, Chan GK, Yen TJ (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. doi:10.1083/jcb.200102093. PMC 2196190. PMID 11535616.
  7. ↑ Zhang Y, Lees E (August 2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15): 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. PMC 87243. PMID 11438673.
  8. ↑ Sihn CR, Suh EJ, Lee KH, Kim TY, Kim SH (November 2003). "p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells". Cancer Lett. 201 (2): 203–10. doi:10.1016/s0304-3835(03)00465-8. PMID 14607335.
  9. ↑ Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G (March 2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3): 224–9. doi:10.1038/73338. PMID 10700282.
  10. ↑ 10.0 10.1 Sironi L, Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22): 6371–82. doi:10.1093/emboj/20.22.6371. PMC 125308. PMID 11707408.
  11. ↑ D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D (October 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes Dev. 17 (20): 2520–5. doi:10.1101/gad.267603. PMC 218146. PMID 14561775.
  12. ↑ Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.
  13. ↑ 13.0 13.1 Wassmann K, Benezra R (September 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11193–8. doi:10.1073/pnas.95.19.11193. PMC 21618. PMID 9736712.
  14. ↑ 14.0 14.1 Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ (June 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6): 1393–406. doi:10.1083/jcb.141.6.1393. PMC 2132789. PMID 9628895.
  15. ↑ Fang G, Yu H, Kirschner MW (June 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. 12 (12): 1871–83. doi:10.1101/gad.12.12.1871. PMC 316912. PMID 9637688.
  16. ↑ Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4492–7. doi:10.1073/pnas.081076898. PMC 31862. PMID 11274370.
  17. ↑ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.
  18. ↑ Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM (July 2008). "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint". Neoplasia. 10 (7): 643–52. doi:10.1593/neo.08176. PMC 2435002. PMID 18592005.
  19. ↑ Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME (March 2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2836–9. doi:10.1073/pnas.050580997. PMC 16016. PMID 10706629.
  20. ↑ 20.0 20.1 Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. PMID 10660610.
  21. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  22. ↑ Liu YC, Pan J, Zhang C, Fan W, Collinge M, Bender JR, Weissman SM (April 1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4313–8. doi:10.1073/pnas.96.8.4313. PMC 16329. PMID 10200259.

Further reading

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