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{{Underlinked|date=August 2017}}
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{{Infobox_gene}}
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'''Target of rapamycin complex 2 subunit MAPKAP1''' is a [[protein]] that in humans is encoded by the ''MAPKAP1'' [[gene]].<ref name="pmid15363842">{{cite journal |vauthors=Schroder W, Cloonan N, Bushell G, Sculley T | title = Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene | journal = Gene | volume = 339 | issue =  | pages = 17–23 |date=Sep 2004 | pmid = 15363842 | pmc =  | doi = 10.1016/j.gene.2004.07.001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mitogen-activated protein kinase associated protein 1
| HGNCid = 18752
| Symbol = MAPKAP1
| AltSymbols =; MIP1; MGC2745; SIN1; SIN1b; SIN1g
| OMIM = 610558
| ECnumber = 
| Homologene = 11473
| MGIid = 2444554
| GeneAtlas_image1 = PBB_GE_MAPKAP1_217808_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0017016 |text = Ras GTPase binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
  | Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79109
    | Hs_Ensembl = ENSG00000119487
    | Hs_RefseqProtein = NP_001006618
    | Hs_RefseqmRNA = NM_001006617
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 127239494
    | Hs_GenLoc_end = 127509334
    | Hs_Uniprot = Q9BPZ7
    | Mm_EntrezGene = 227743
    | Mm_Ensembl = ENSMUSG00000038696
    | Mm_RefseqmRNA = NM_177345
    | Mm_RefseqProtein = NP_796319
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 34228887
    | Mm_GenLoc_end = 34445923
    | Mm_Uniprot = 
  }}
}}
'''Mitogen-activated protein kinase associated protein 1''', also known as '''MAPKAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109| accessdate = }}</ref>
| summary_text = This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Colicelli J, Nicolette C, Birchmeier C, ''et al.'' |title=Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2913-7 |year= 1991 |pmid= 1849280 |doi=  }}
*{{cite journal  | author=Colicelli J |title=Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2913–7 |year= 1991 |pmid= 1849280 |doi=10.1073/pnas.88.7.2913 | pmc=51350 |name-list-format=vanc| author2=Nicolette C  | author3=Birchmeier C  | display-authors=3  | last4=Rodgers  | first4=L  | last5=Riggs  | first5=M  | last6=Wigler  | first6=M  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |name-list-format=vanc| author2=Smith FD  | author3=Stark C  | display-authors=3  | last4=Wells  | first4=Clark D.  | last5=Fawcett  | first5=James P.  | last6=Kulkarni  | first6=Sarang  | last7=Metalnikov  | first7=Pavel  | last8=O'Donnell  | first8=Paul  | last9=Taylor  | first9=Paul }}
*{{cite journal | author=Schroder W, Cloonan N, Bushell G, Sculley T |title=Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. |journal=Gene |volume=339 |issue=  |pages= 17-23 |year= 2004 |pmid= 15363842 |doi= 10.1016/j.gene.2004.07.001 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Schroder W, Bushell G, Sculley T |title=The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins |journal=Cell. Signal. |volume=17 |issue= 6 |pages= 761–7 |year= 2005 |pmid= 15722200 |doi= 10.1016/j.cellsig.2004.10.015 }}
*{{cite journal | author=Schroder W, Bushell G, Sculley T |title=The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. |journal=Cell. Signal. |volume=17 |issue= 6 |pages= 761-7 |year= 2005 |pmid= 15722200 |doi= 10.1016/j.cellsig.2004.10.015 }}
*{{cite journal  | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |name-list-format=vanc| author2=Muster N  | author3=Koch HB  | display-authors=3  | last4=Yates Jr  | first4=3rd  | last5=Hermeking  | first5=H }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal  | author=Cheng J |title=Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5955–64 |year= 2005 |pmid= 15988011 |doi= 10.1128/MCB.25.14.5955-5964.2005 | pmc=1168836  |name-list-format=vanc| author2=Zhang D  | author3=Kim K | display-authors=3  | last4=Zhao  | first4=Y. | last5=Zhao  | first5=Y.  | last6=Su  | first6=B. }}
*{{cite journal | author=Cheng J, Zhang D, Kim K, ''et al.'' |title=Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5955-64 |year= 2005 |pmid= 15988011 |doi= 10.1128/MCB.25.14.5955-5964.2005 }}
*{{cite journal  | author=Venables JP |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289–303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233  |name-list-format=vanc| author2=Bourgeois CF | author3=Dalgliesh C  | display-authors=3  | last4=Kister  | first4=L  | last5=Stevenin  | first5=J  | last6=Elliott  | first6=DJ }}
*{{cite journal  | author=Venables JP, Bourgeois CF, Dalgliesh C, ''et al.'' |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289-303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F. | last8=Gibbons  | first8=Francis D. | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Frias MA |title=mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1865–70 |year= 2006 |pmid= 16919458 |doi= 10.1016/j.cub.2006.08.001  |name-list-format=vanc| author2=Thoreen CC  | author3=Jaffe JD  | display-authors=3  | last4=Schroder  | first4=Wayne  | last5=Sculley  | first5=Tom  | last6=Carr  | first6=Steven A.  | last7=Sabatini  | first7=David M. }}
*{{cite journal | author=Frias MA, Thoreen CC, Jaffe JD, ''et al.'' |title=mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1865-70 |year= 2006 |pmid= 16919458 |doi= 10.1016/j.cub.2006.08.001 }}
*{{cite journal  | author=Jacinto E |title=SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity |journal=Cell |volume=127 |issue= 1 |pages= 125–37 |year= 2006 |pmid= 16962653 |doi= 10.1016/j.cell.2006.08.033  |name-list-format=vanc| author2=Facchinetti V  | author3=Liu D  | display-authors=3  | last4=Soto  | first4=Nelyn  | last5=Wei  | first5=Shiniu  | last6=Jung  | first6=Sung Yun  | last7=Huang  | first7=Qiaojia  | last8=Qin  | first8=Jun  | last9=Su  | first9=Bing }}
*{{cite journal  | author=Jacinto E, Facchinetti V, Liu D, ''et al.'' |title=SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. |journal=Cell |volume=127 |issue= 1 |pages= 125-37 |year= 2006 |pmid= 16962653 |doi= 10.1016/j.cell.2006.08.033 }}
*{{cite journal  |vauthors=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820–32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206  | pmc=1619946 }}
*{{cite journal | author=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820-32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206 }}
*{{cite journal  | author=Makino C |title=Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway |journal=Genes Cells |volume=11 |issue= 11 |pages= 1239–51 |year= 2007 |pmid= 17054722 |doi= 10.1111/j.1365-2443.2006.01016.x  |name-list-format=vanc| author2=Sano Y  | author3=Shinagawa T  | display-authors=3  | last4=Millar  | first4=Jonathan B. A.  | last5=Ishii  | first5=Shunsuke }}
*{{cite journal  | author=Makino C, Sano Y, Shinagawa T, ''et al.'' |title=Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. |journal=Genes Cells |volume=11 |issue= 11 |pages= 1239-51 |year= 2007 |pmid= 17054722 |doi= 10.1111/j.1365-2443.2006.01016.x }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Schroder WA |title=Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1279–89 |year= 2007 |pmid= 17303383 |doi= 10.1016/j.cellsig.2007.01.013 |name-list-format=vanc| author2=Buck M  | author3=Cloonan N  | display-authors=3  | last4=Hancock  | first4=John F.  | last5=Suhrbier  | first5=Andreas  | last6=Sculley  | first6=Tom  | last7=Bushell  | first7=Gillian }}
*{{cite journal | author=Schroder WA, Buck M, Cloonan N, ''et al.'' |title=Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1279-89 |year= 2007 |pmid= 17303383 |doi= 10.1016/j.cellsig.2007.01.013 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:08, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.[1][2]

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.[2]

References

  1. ↑ Schroder W, Cloonan N, Bushell G, Sculley T (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
  2. ↑ 2.0 2.1 "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

Further reading



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