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{{Infobox_gene}}
{{PBB_Controls
'''Microtubule-associated protein RP/EB family member 2''' is a [[protein]] that in humans is encoded by the ''MAPRE2'' [[gene]].<ref name="pmid9233623">{{cite journal | vauthors = Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M | title = RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells | journal = J Immunol | volume = 159 | issue = 3 | pages = 1276–83 | date = Aug 1997 | pmid = 9233623 | pmc =  | doi =  }}</ref><ref name="pmid12475954">{{cite journal | vauthors = Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ | title = EB1 targets to kinetochores with attached, polymerizing microtubules | journal = Mol Biol Cell | volume = 13 | issue = 12 | pages = 4308–16 | date = Dec 2002 | pmid = 12475954 | pmc = 138635 | doi = 10.1091/mbc.E02-04-0236 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10982| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein, RP/EB family, member 2
| HGNCid = 6891
| Symbol = MAPRE2
| AltSymbols =; RP1; EB1; EB2
| OMIM = 605789
| ECnumber = 
| Homologene = 75027
| MGIid = 106271
| GeneAtlas_image1 = PBB_GE_MAPRE2_202501_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAPRE2_213489_at_tn.png
| Function = {{GNF_GO|id=GO:0008017 |text = microtubule binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10982
    | Hs_Ensembl = ENSG00000166974
    | Hs_RefseqProtein = NP_055083
    | Hs_RefseqmRNA = NM_014268
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 30875379
    | Hs_GenLoc_end = 30975820
    | Hs_Uniprot = Q15555
    | Mm_EntrezGene = 212307
    | Mm_Ensembl = ENSMUSG00000024277
    | Mm_RefseqmRNA = NM_153058
    | Mm_RefseqProtein = NP_694698
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 23946994
    | Mm_GenLoc_end = 24036863
    | Mm_Uniprot = Q3TG90
  }}
}}
'''Microtubule-associated protein, RP/EB family, member 2''', also known as '''MAPRE2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10982| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.<ref name="entrez">{{cite web | title = Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10982| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAPRE2 has been shown to [[Protein-protein interaction|interact]] with [[APC (gene)|APC]].<ref name=pmid7606712>{{cite journal | vauthors = Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW | title = APC binds to the novel protein EB1  | journal = Cancer Res. | volume = 55 | issue = 14 | pages = 2972–7 | date = Jul 1995 | pmid = 7606712 }}</ref><ref name=pmid11470413>{{cite journal | vauthors = Nakamura M, Zhou XZ, Lu KP | title = Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization  | journal = Curr. Biol. | volume = 11 | issue = 13 | pages = 1062–7 | date = Jul 2001 | pmid = 11470413 | doi = 10.1016/S0960-9822(01)00297-4 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tirnauer JS, Bierer BE | title = EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability | journal = J. Cell Biol. | volume = 149 | issue = 4 | pages = 761–6 | year = 2000 | pmid = 10811817 | pmc = 2174556 | doi = 10.1083/jcb.149.4.761 }}
| citations =
* {{cite journal | vauthors = Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW | title = APC binds to the novel protein EB1 | journal = Cancer Res. | volume = 55 | issue = 14 | pages = 2972–7 | year = 1995 | pmid = 7606712 | doi =  }}
*{{cite journal | author=Tirnauer JS, Bierer BE |title=EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. |journal=J. Cell Biol. |volume=149 |issue= 4 |pages= 761-6 |year= 2000 |pmid= 10811817 |doi= }}
* {{cite journal | vauthors = Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE | title = The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 18 | pages = 10596–601 | year = 1998 | pmid = 9724749 | pmc = 27940 | doi = 10.1073/pnas.95.18.10596 }}
*{{cite journal | author=Su LK, Burrell M, Hill DE, ''et al.'' |title=APC binds to the novel protein EB1. |journal=Cancer Res. |volume=55 |issue= 14 |pages= 2972-7 |year= 1995 |pmid= 7606712 |doi=  }}
* {{cite journal | vauthors = Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM | title = EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle | journal = Oncogene | volume = 17 | issue = 26 | pages = 3471–7 | year = 1999 | pmid = 10030671 | doi = 10.1038/sj.onc.1202247 }}
*{{cite journal | author=Renner C, Pfitzenmeier JP, Gerlach K, ''et al.'' |title=RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. |journal=J. Immunol. |volume=159 |issue= 3 |pages= 1276-83 |year= 1997 |pmid= 9233623 |doi=  }}
* {{cite journal | vauthors = Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C | title = EB/RP gene family encodes tubulin binding proteins | journal = Int. J. Cancer | volume = 81 | issue = 2 | pages = 275–84 | year = 1999 | pmid = 10188731 | doi = 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z }}
*{{cite journal  | author=Berrueta L, Kraeft SK, Tirnauer JS, ''et al.'' |title=The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10596-601 |year= 1998 |pmid= 9724749 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Morrison EE, Wardleworth BN, Askham JM, ''et al.'' |title=EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. |journal=Oncogene |volume=17 |issue= 26 |pages= 3471-7 |year= 1999 |pmid= 10030671 |doi= 10.1038/sj.onc.1202247 }}
* {{cite journal | vauthors = Nakamura M, Zhou XZ, Lu KP | title = Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization | journal = Curr. Biol. | volume = 11 | issue = 13 | pages = 1062–7 | year = 2001 | pmid = 11470413 | doi = 10.1016/S0960-9822(01)00297-4 }}
*{{cite journal | author=Juwana JP, Henderikx P, Mischo A, ''et al.'' |title=EB/RP gene family encodes tubulin binding proteins. |journal=Int. J. Cancer |volume=81 |issue= 2 |pages= 275-84 |year= 1999 |pmid= 10188731 |doi= }}
* {{cite journal | vauthors = Askham JM, Vaughan KT, Goodson HV, Morrison EE | title = Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome | journal = Mol. Biol. Cell | volume = 13 | issue = 10 | pages = 3627–45 | year = 2003 | pmid = 12388762 | pmc = 129971 | doi = 10.1091/mbc.E02-01-0061 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Bu W, Su LK | title = Characterization of functional domains of human EB1 family proteins | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49721–31 | year = 2004 | pmid = 14514668 | doi = 10.1074/jbc.M306194200 }}
*{{cite journal | author=Nakamura M, Zhou XZ, Lu KP |title=Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. |journal=Curr. Biol. |volume=11 |issue= 13 |pages= 1062-7 |year= 2001 |pmid= 11470413 |doi= }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Askham JM, Vaughan KT, Goodson HV, Morrison EE |title=Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3627-45 |year= 2003 |pmid= 12388762 |doi= 10.1091/mbc.E02-01-0061 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ |title=EB1 targets to kinetochores with attached, polymerizing microtubules. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4308-16 |year= 2003 |pmid= 12475954 |doi= 10.1091/mbc.E02-04-0236 }}
* {{cite journal | vauthors = Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A | title = CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex | journal = J. Cell Biol. | volume = 168 | issue = 1 | pages = 141–53 | year = 2005 | pmid = 15631994 | pmc = 2171674 | doi = 10.1083/jcb.200405094 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Xu H, Hebert MD | title = A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin | journal = BMC Cell Biol. | volume = 6 | pages = 23 | year = 2006 | pmid = 15862129 | pmc = 1097723 | doi = 10.1186/1471-2121-6-23 }}
*{{cite journal  | author=Bu W, Su LK |title=Characterization of functional domains of human EB1 family proteins. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49721-31 |year= 2004 |pmid= 14514668 |doi= 10.1074/jbc.M306194200 }}
* {{cite journal | vauthors = Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N | title = Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway | journal = Oncogene | volume = 24 | issue = 44 | pages = 6637–45 | year = 2005 | pmid = 16007168 | doi = 10.1038/sj.onc.1208819 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, ''et al.'' |title=CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. |journal=J. Cell Biol. |volume=168 |issue= 1 |pages= 141-53 |year= 2005 |pmid= 15631994 |doi= 10.1083/jcb.200405094 }}
*{{cite journal | author=Xu H, Hebert MD |title=A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 23 |year= 2006 |pmid= 15862129 |doi= 10.1186/1471-2121-6-23 }}
*{{cite journal | author=Wang Y, Zhou X, Zhu H, ''et al.'' |title=Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway. |journal=Oncogene |volume=24 |issue= 44 |pages= 6637-45 |year= 2005 |pmid= 16007168 |doi= 10.1038/sj.onc.1208819 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:08, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.[1][2][3]

Function

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[3]

Interactions

MAPRE2 has been shown to interact with APC.[4][5]

References

  1. ↑ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. PMID 9233623.
  2. ↑ Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC 138635. PMID 12475954.
  3. ↑ 3.0 3.1 "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2".
  4. ↑ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.
  5. ↑ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413.

Further reading


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