MIB2 (gene): Difference between revisions

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{{Infobox_gene}}
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'''E3 ubiquitin-protein ligase MIB2''' is an [[enzyme]] that in humans is encoded by the ''MIB2'' [[gene]].<ref name="pmid12761501">{{cite journal |vauthors=Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 |date=May 2003 | pmid = 12761501 | pmc =  | doi = 10.1038/sj.onc.1206406 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=142678| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mindbomb homolog 2 (Drosophila)
| HGNCid = 30577
| Symbol = MIB2
| AltSymbols =; FLJ20648; FLJ39787; ZZANK1; ZZZ5
| OMIM = 
| ECnumber = 
| Homologene = 16062
| MGIid = 2679684
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005769 |text = early endosome}}
| Process = {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 142678
    | Hs_Ensembl = ENSG00000197530
    | Hs_RefseqProtein = XP_001125956
    | Hs_RefseqmRNA = XM_001125956
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 1540736
    | Hs_GenLoc_end = 1555853
    | Hs_Uniprot = Q96AX9
    | Mm_EntrezGene = 76580
    | Mm_Ensembl = ENSMUSG00000029060
    | Mm_RefseqmRNA = NM_145124
    | Mm_RefseqProtein = NP_660106
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 154498482
    | Mm_GenLoc_end = 154512998
    | Mm_Uniprot = Q8R516
  }}
}}
'''Mindbomb homolog 2 (Drosophila)''', also known as '''MIB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=142678| accessdate = }}</ref>


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==Interactions==
MIB2 (gene) has been shown to [[Protein-protein interaction|interact]] with [[Actin, alpha 1]].<ref name=pmid14507647>{{cite journal |last=Takeuchi |first=Tamotsu |authorlink= |author2=Heng Henry H Q |author3=Ye Christine J |author4=Liang Sheng-Ben |author5=Iwata Jun |author6=Sonobe Hiroshi |author7=Ohtsuki Yuji  |date=Oct 2003 |title=Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma |journal=Am. J. Pathol. |volume=163 |issue=4 |pages=1395–404 |publisher= |location = United States| issn = 0002-9440| pmid = 14507647 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1868282 |doi=10.1016/S0002-9440(10)63497-9 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307-18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal   |vauthors=Takeuchi T, Heng HH, Ye CJ, etal |title=Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1395–404 |year= 2003 |pmid= 14507647 |doi= 10.1016/S0002-9440(10)63497-9| pmc=1868282 }}
*{{cite journal | author=Takeuchi T, Heng HH, Ye CJ, ''et al.'' |title=Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1395-404 |year= 2003 |pmid= 14507647 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Koo BK, Yoon KJ, Yoo KW, etal |title=Mind bomb-2 is an E3 ligase for Notch ligand. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22335–42 |year= 2005 |pmid= 15824097 |doi= 10.1074/jbc.M501631200 }}
*{{cite journal | author=Koo BK, Yoon KJ, Yoo KW, ''et al.'' |title=Mind bomb-2 is an E3 ligase for Notch ligand. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22335-42 |year= 2005 |pmid= 15824097 |doi= 10.1074/jbc.M501631200 }}
*{{cite journal  |vauthors=Takeuchi T, Adachi Y, Ohtsuki Y |title=Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. |journal=DNA Cell Biol. |volume=24 |issue= 5 |pages= 339–44 |year= 2005 |pmid= 15869411 |doi= 10.1089/dna.2005.24.339 }}
*{{cite journal  | author=Takeuchi T, Adachi Y, Ohtsuki Y |title=Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. |journal=DNA Cell Biol. |volume=24 |issue= 5 |pages= 339-44 |year= 2005 |pmid= 15869411 |doi= 10.1089/dna.2005.24.339 }}
*{{cite journal  |vauthors=Takeuchi T, Adachi Y, Ohtsuki Y |title=Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. |journal=Am. J. Pathol. |volume=166 |issue= 6 |pages= 1817–26 |year= 2005 |pmid= 15920166 |doi= 10.1016/S0002-9440(10)62491-1| pmc=1602431 }}
*{{cite journal  | author=Takeuchi T, Adachi Y, Ohtsuki Y |title=Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. |journal=Am. J. Pathol. |volume=166 |issue= 6 |pages= 1817-26 |year= 2005 |pmid= 15920166 |doi=  }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Takeuchi T, Adachi Y, Sonobe H, etal |title=A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. |journal=Oncogene |volume=25 |issue= 53 |pages= 7059–69 |year= 2006 |pmid= 16715130 |doi= 10.1038/sj.onc.1209688 }}
*{{cite journal | author=Takeuchi T, Adachi Y, Sonobe H, ''et al.'' |title=A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. |journal=Oncogene |volume=25 |issue= 53 |pages= 7059-69 |year= 2006 |pmid= 16715130 |doi= 10.1038/sj.onc.1209688 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:41, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.[1][2]


Interactions

MIB2 (gene) has been shown to interact with Actin, alpha 1.[3]

References

  1. ↑ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  2. ↑ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
  3. ↑ Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Further reading



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