MORF4L1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Mortality factor 4-like protein 1''' is a [[protein]] that in humans is encoded by the ''MORF4L1'' [[gene]].<ref name="pmid8619474">{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | pmc =  | doi = 10.1006/abio.1996.0138 }}</ref><ref name="pmid9110174">{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MORF4L1 mortality factor 4 like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10933| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_MORF4L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2aql.
| PDB = {{PDB2|2aql}}, {{PDB2|2f5j}}, {{PDB2|2f5k}}
| Name = Mortality factor 4 like 1
| HGNCid = 16989
| Symbol = MORF4L1
| AltSymbols =; Eaf3; FWP006; HsT17725; MGC10631; MORFRG15; MRG15; S863-6
| OMIM = 607303
| ECnumber = 
| Homologene = 86043
| MGIid = 1096551
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10933
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006782
    | Hs_RefseqmRNA = NM_006791
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 21761
    | Mm_Ensembl = ENSMUSG00000062270
    | Mm_RefseqmRNA = NM_001039147
    | Mm_RefseqProtein = NP_001034236
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 89889562
    | Mm_GenLoc_end = 89912655
    | Mm_Uniprot = Q3U5J6
  }}
}}
'''Mortality factor 4 like 1''', also known as '''MORF4L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MORF4L1 mortality factor 4 like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10933| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MORF4L1 has been shown to [[Protein-protein interaction|interact]] with [[MYST1]],<ref name=pmid12397079>{{cite journal | vauthors = Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM | title = MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 52 | pages = 50860–6 | date = Dec 2002 | pmid = 12397079 | doi = 10.1074/jbc.M203839200 }}</ref> [[Retinoblastoma protein]]<ref name=pmid12397079/><ref name=pmid11500496>{{cite journal | vauthors = Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM | title = MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 42 | pages = 39171–8 | date = Oct 2001 | pmid = 11500496 | doi = 10.1074/jbc.M103435200 }}</ref> and [[MRFAP1]].<ref name=pmid12397079/><ref name=pmid11500496/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Doyon Y, Côté J | title = The highly conserved and multifunctional NuA4 HAT complex | journal = Current Opinion in Genetics & Development | volume = 14 | issue = 2 | pages = 147–54 | date = Apr 2004 | pmid = 15196461 | doi = 10.1016/j.gde.2004.02.009 }}
| citations =
* {{cite journal | vauthors = Pena AN, Pereira-Smith OM | title = The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging | journal = Annals of the New York Academy of Sciences | volume = 1100 | issue = 1 | pages = 299–305 | date = Apr 2007 | pmid = 17460191 | doi = 10.1196/annals.1395.031 }}
*{{cite journal | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
* {{cite journal | vauthors = Bertram MJ, Bérubé NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM | title = Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1479–85 | date = Feb 1999 | pmid = 9891081 | pmc = 116076 | doi =  10.1128/mcb.19.2.1479}}
*{{cite journal | author=Pena AN, Pereira-Smith OM |title=The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. |journal=Ann. N. Y. Acad. Sci. |volume=1100 |issue= |pages= 299-305 |year= 2007 |pmid= 17460191 |doi= 10.1196/annals.1395.031 }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM | title = MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 42 | pages = 39171–8 | date = Oct 2001 | pmid = 11500496 | doi = 10.1074/jbc.M103435200 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
* {{cite journal | vauthors = Yochum GS, Ayer DE | title = Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split | journal = Molecular and Cellular Biology | volume = 22 | issue = 22 | pages = 7868–76 | date = Nov 2002 | pmid = 12391155 | pmc = 134742 | doi = 10.1128/MCB.22.22.7868-7876.2002 }}
*{{cite journal  | author=Bertram MJ, Bérubé NG, Hang-Swanson X, ''et al.'' |title=Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1479-85 |year= 1999 |pmid= 9891081 |doi=  }}
* {{cite journal | vauthors = Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM | title = MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 52 | pages = 50860–6 | date = Dec 2002 | pmid = 12397079 | doi = 10.1074/jbc.M203839200 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
* {{cite journal | vauthors = Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW | title = Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 42733–6 | date = Oct 2003 | pmid = 12963728 | doi = 10.1074/jbc.C300389200 }}
*{{cite journal | author=Leung JK, Berube N, Venable S, ''et al.'' |title=MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39171-8 |year= 2001 |pmid= 11500496 |doi= 10.1074/jbc.M103435200 }}
* {{cite journal | vauthors = Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM | title = MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49618–24 | date = Dec 2003 | pmid = 14506250 | doi = 10.1074/jbc.M309192200 }}
*{{cite journal | author=Yochum GS, Ayer DE |title=Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 7868-76 |year= 2002 |pmid= 12391155 |doi= }}
* {{cite journal | vauthors = Doyon Y, Selleck W, Lane WS, Tan S, Côté J | title = Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans | journal = Molecular and Cellular Biology | volume = 24 | issue = 5 | pages = 1884–96 | date = Mar 2004 | pmid = 14966270 | pmc = 350560 | doi = 10.1128/MCB.24.5.1884-1896.2004 }}
*{{cite journal | author=Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM |title=MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50860-6 |year= 2003 |pmid= 12397079 |doi= 10.1074/jbc.M203839200 }}
* {{cite journal | vauthors = Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM | title = PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice | journal = Molecular and Cellular Biology | volume = 24 | issue = 19 | pages = 8366–73 | date = Oct 2004 | pmid = 15367658 | pmc = 516751 | doi = 10.1128/MCB.24.19.8366-8373.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J | title = Large-scale cDNA transfection screening for genes related to cancer development and progression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 44 | pages = 15724–9 | date = Nov 2004 | pmid = 15498874 | pmc = 524842 | doi = 10.1073/pnas.0404089101 }}
*{{cite journal  | author=Cai Y, Jin J, Tomomori-Sato C, ''et al.'' |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733-6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Tominaga K, Leung JK, Rookard P, ''et al.'' |title=MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49618-24 |year= 2004 |pmid= 14506250 |doi= 10.1074/jbc.M309192200 }}
* {{cite journal | vauthors = Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW | title = The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes | journal = The Journal of Biological Chemistry | volume = 280 | issue = 14 | pages = 13665–70 | date = Apr 2005 | pmid = 15647280 | doi = 10.1074/jbc.M500001200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Doyon Y, Selleck W, Lane WS, ''et al.'' |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884-96 |year= 2004 |pmid= 14966270 |doi= }}
*{{cite journal | author=Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM |title=PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. |journal=Mol. Cell. Biol. |volume=24 |issue= 19 |pages= 8366-73 |year= 2004 |pmid= 15367658 |doi= 10.1128/MCB.24.19.8366-8373.2004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724-9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Cai Y, Jin J, Florens L, ''et al.'' |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665-70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=10933}}
{{WikiDoc Sources}}
 
 
{{Protein-stub}}

Latest revision as of 06:45, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.[1][2][3]

Interactions

MORF4L1 has been shown to interact with MYST1,[4] Retinoblastoma protein[4][5] and MRFAP1.[4][5]

References

  1. ↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  2. ↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  3. ↑ "Entrez Gene: MORF4L1 mortality factor 4 like 1".
  4. ↑ 4.0 4.1 4.2 Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079.
  5. ↑ 5.0 5.1 Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi:10.1074/jbc.M103435200. PMID 11500496.

Further reading


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