Mebhydrolin: Difference between revisions

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{{drugbox |
{{Drugbox
| IUPAC_name       = 9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-β-carboline
| Verifiedfields = changed
| image             =
| Watchedfields = changed
| ATC_prefix        = R06
| verifiedrevid = 462100967
| ATC_suffix        = AX15
| IUPAC_name = 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1''H''-pyrido[4,3-''b'']indole
| CAS_number        = 524-81-2
| image = Mebhydroline.png
| CAS_supplemental  = 6153-33-9<ref name="MeSH diazoline">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=diazoline |title=Diazoline |publisher=US National Institutes of Health, National Library of Medicine |accessdate=2007-03-02 |format=HTML |work=National Library of Medicine - Medical Subject Headings }}</ref>
 
| PubChem = 10458737
<!--Clinical data-->
| C = 19 |H = 20 |N = 2<ref name="ChemIndustry">{{cite web |url=http://www.chemindustry.com/chemicals/969111.html |title=Mebhydrolin chemical information |accessdate=2007-03-02 |format=HTML |work=PubChem}}</ref>
| tradename =
| molecular_weight  = 276.376 g/mol
| Drugs.com = {{drugs.com|international|mebhydrolin}}
| smiles            = CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=CC=C4
| pregnancy_category = Not established<ref name="Intekom">{{cite web | url = http://home.intekom.com/pharm/bayer/fabahist.html | title = FABAHISTIN 50 mg (Tablets) | date = September 1970 | accessdate = 2007-03-02 | work = South African Electronic Package Inserts}} {{Dead link|date=October 2010|bot=H3llBot}}</ref>
| synonyms          = Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate<ref name="MeSH mebhydroline">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=mebhydroline |title=Mebhydroline |publisher=US National Institutes of Health, National Library of Medicine |accessdate=2007-03-02 |format=HTML |work=National Library of Medicine - Medical Subject Headings }}</ref>
| pregnancy_category= Not established<ref name="Intekom">{{cite web |url=http://www.intekom.com/pharm/bayer/fabahist.html |title=FABAHISTIN 50 mg (Tablets) |date=1970-09 |accessdate=2007-03-02 |format=HTML |work=South African Electronic Package Inserts }}</ref>
| routes_of_administration = oral<ref name="Intekom"/>
| routes_of_administration = oral<ref name="Intekom"/>
<!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 524-81-2
| CAS_supplemental = 6153-33-9<ref name="MeSH diazoline">{{cite web | url = http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=diazoline | title = Diazoline | publisher = US National Institutes of Health, National Library of Medicine | accessdate = 2007-03-02 | work = National Library of Medicine - Medical Subject Headings}}</ref>
| ATC_prefix = R06
| ATC_suffix = AX15
| PubChem = 22530
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 21129
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 9SUK9B7XVY
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08161
<!--Chemical data-->
| C=19 | H=20 | N=2<ref name="ChemIndustry">{{cite web | url = http://www.chemindustry.com/chemicals/969111.html | title = Mebhydrolin chemical information | accessdate = 2007-03-02 | work = PubChem}}</ref>
| molecular_weight = 276.376 g/mol
| smiles = CN3Cc4c1ccccc1n(Cc2ccccc2)c4CC3
| InChI = 1/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
| InChIKey = FQQIIPAOSKSOJM-UHFFFAOYAM
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = FQQIIPAOSKSOJM-UHFFFAOYSA-N
| synonyms = 9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-gamma-carboline, Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate<ref name="MeSH mebhydroline">{{cite web | url = http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=mebhydroline | title = Mebhydroline | publisher = US National Institutes of Health, National Library of Medicine | accessdate = 2007-03-02 | work = National Library of Medicine - Medical Subject Headings}}</ref>
}}
}}
 
__NOTOC__
{{SI}}
{{SI}}
 
{{CMG}}
 
==Overview==
==Overview==
'''Mebhydrolin''' ([[International Nonproprietary Name|INN]]) or '''mebhydroline''' is an [[antihistamine]]. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU).  It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.  
'''Mebhydrolin''' ([[International Nonproprietary Name|INN]]) or '''mebhydroline''' is an [[antihistamine]]. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU).  It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.


Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6119605&dopt=Abstract |title=Interaction between ethanol and antihistamines: 3. mebhydrolin. |accessdate=2007-03-02 |last=Franks |first=HM |coauthors= M. Lawrie, VV Schabinsky, GA Starmer, RK Teo |date=1981-10-31 |format=HTML |work=Med J Aust. |language=English }}</ref>
Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.<ref>{{cite journal |author=Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK |title=Interaction between ethanol and antihistamines: 3. mebhydrolin |journal=Med. J. Aust. |volume=2 |issue=9 |pages=477–9 |date=October 1981 |pmid=6119605 }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist|2}}


{{Antihistamines}}
{{Antihistamines}}


[[Category:Antihistamines]]
[[Category:H1 receptor antagonists]]
[[Category:Indoles]]
[[Category:Drug]]
 
 
{{WH}}
{{WikiDoc Sources}}

Latest revision as of 18:12, 8 April 2015

Mebhydrolin
Clinical data
Synonyms9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-gamma-carboline, Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate[2]
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Not established[1]
Routes of
administration		oral[1]
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H20N2[4]
Molar mass276.376 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mebhydrolin (INN) or mebhydroline is an antihistamine. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU). It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.

Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.[5]

References

  1. ↑ 1.0 1.1 "FABAHISTIN 50 mg (Tablets)". South African Electronic Package Inserts. September 1970. Retrieved 2007-03-02.[dead link]
  2. ↑ "Mebhydroline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.
  3. ↑ "Diazoline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.
  4. ↑ "Mebhydrolin chemical information". PubChem. Retrieved 2007-03-02.
  5. ↑ Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK (October 1981). "Interaction between ethanol and antihistamines: 3. mebhydrolin". Med. J. Aust. 2 (9): 477–9. PMID 6119605.
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