Whipple's disease: Difference between revisions

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	Whipple's disease;
	light microscopy of small intestine;Whipples Disease: enlarged villus with abundant macrophages
ICD-10	K90.8
ICD-9	040.2
DiseasesDB	14124
MedlinePlus	000209
MeSH	D008061

VisualWikitext

Latest revision as of 00:44, 30 July 2020

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Synonyms and keywords: Intestinal lipodystrophy; Whipple disease

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Whipple's disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

External Links

NIH

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 __NOTOC__
-{{Infobox_Disease
+'''For patient information, click [[Whipple's disease (patient information)|here]]'''
+{{CMG}}; {{AE}} {{SSH}}
+<small>{{Infobox_Disease
   | Name           = {{PAGENAME}}
   | Image          = Whipple2.jpg
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   | MedlinePlus    = 000209
   | MeshID         = D008061
-}}
+}}</small>
 {{Whipple's disease}}
-'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
+{{SK}} Intestinal lipodystrophy; Whipple disease
+==[[Whipple's disease overview|Overview]]==
+==[[Whipple's disease historical perspective|Historical Perspective]]==
+==[[Whipple's disease classification|Classification]]==
+==[[Whipple's disease pathophysiology|Pathophysiology]]==
+==[[Whipple's disease causes|Causes]]==
-{{CMG}}
+==[[Whipple's disease differential diagnosis|Differentiating Whipple's disease from other Diseases]]==
-==Overview==
+==[[Whipple's disease epidemiology and demographics|Epidemiology and Demographics]]==
-Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms.<ref name=Bai_2004>{{cite journal |author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E |title=Whipple's disease |journal=Clin Gastroenterol Hepatol |volume=2 |issue=10 |pages=849-60 |year=2004 |pmid=15476147}}</ref>. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; untreated the disease is ultimately fatal.
-==Mnemonics==
+==[[Whipple's disease risk factors|Risk Factors]]==
-<b>W H I P P L E S</b>
-*[[Weight Loss]]
-*[[Hyperpigmentation]] of the skin
-*Infection with [[Tropheryma whipplei]]
-*PAS positive granules in [[macrophage]]
-*[[Polyarthritis]]
-*[[Lymphadenopathy]]
-*[[Enteric]] Involvement
-*[[Steatorrhea]]
-==Symptoms==
+==[[Whipple's disease screening|Screening]]==
+==[[Whipple's disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 ==Diagnosis==
-Common clinical signs and symptoms of Whipple's disease include weight loss, diarrhea, joint pain or arthritis, fever, and [[adenopathy]]. Diagnosis is made by intestinal [[biopsy]], which reveals presence of the organism as [[Periodic acid-Schiff|PAS]]-positive [[macrophage]] inclusions. [[Immunohistochemical]] staining for antibodies against <i>T. whipplei</i> has been used to detect the organism in a variety if tissues, and a confirmatory [[PCR]]-based assay is also available.
+[[Whipple's disease history and symptoms|History and Symptoms]] | [[Whipple's disease physical examination|Physical Examination]] | [[Whipple's disease laboratory findings|Laboratory Findings]] | [[Whipple's disease electrocardiogram|Electrocardiogram]] | [[Whipple's disease x ray|X Ray]] | [[Whipple's disease CT|CT]] | [[Whipple's disease MRI|MRI]] | [[Whipple's disease ultrasound|Ultrasound]] | [[Whipple's disease other imaging findings|Other Imaging Findings]] | [[Whipple's disease other diagnostic studies|Other Diagnostic Studies]]
-[[Endoscopy]] of the [[duodenum]] and [[jejunum]] can reveal pale yellow shaggy mucosa with erythematous eroded patches in patients with classic intestinal Whipple's disease, and small bowel [[X-ray]]s may show some thickened folds.
 ==Treatment==
+[[Whipple's disease medical therapy|Medical Therapy]] | [[Whipple's disease surgery|Surgery]] | [[Whipple's disease primary prevention|Primary Prevention]] | [[Whipple's disease secondary prevention|Secondary Prevention]] | [[Whipple's disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Whipple's disease future or investigational therapies|Future or Investigational Therapies]]
-==References==
+==Case Studies==
-<!-- ---------------------------------------------------------------
+[[Whipple's disease case study one|Case #1]]
-See http://en.wikipedia.org/wiki/Wikipedia:Footnotes for a
-discussion of different citation methods and how to generate
-footnotes using the <ref> & </ref> tags and the {{Reflist}} template
--------------------------------------------------------------------- -->
-{{Reflist|2}}
-==External links==
+==External Links==
 * [http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/ NIH]
-* [http://www.merck.com/mmhe/sec09/ch125/ch125e.html Merck]
-{{Gastroenterology}}
-[[de:Morbus Whipple]]
-[[es:Enfermedad de Whipple]]
-[[fr:Maladie de Whipple]]
-[[it:Morbo di Whipple]]
-[[nl:Ziekte van Whipple]]
-[[pl:Choroba Whipple'a]]
-[[pt:Doença de Whipple]]
-[[sv:Whipples sjukdom]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}
-[[Category:Digestive diseases]]
+[[Category:Medicine]]
 [[Category:Gastroenterology]]
-[[Category:Disease]]
+[[Category:Infectious disease]]
-[[Category:Mature chapter]]
+[[Category:Up-To-Date]]


Whipple's disease
light microscopy of small intestine;Whipples Disease: enlarged villus with abundant macrophages
ICD-10	K90.8
ICD-9	040.2
DiseasesDB	14124
MedlinePlus	000209
MeSH	D008061