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{{Infobox_gene}}
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'''Neighbor of BRCA1 gene 1 protein''' is a [[protein]] that in humans is encoded by the ''NBR1'' [[gene]].<ref name="pmid8069304">{{cite journal |vauthors=Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, ((Bast RC Jr)), Solomon E | title = A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1 | journal = Hum Mol Genet | volume = 3 | issue = 4 | pages = 589–594 |date=Sep 1994 | pmid = 8069304 | pmc =  | doi =10.1093/hmg/3.4.589 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_NBR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wj6.
| PDB = {{PDB2|1wj6}}, {{PDB2|2bkf}}, {{PDB2|2cp8}}, {{PDB2|2g4s}}
| Name = Neighbor of BRCA1 gene 1
| HGNCid = 6746
| Symbol = NBR1
| AltSymbols =; 1A1-3B; KIAA0049; M17S2; MIG19
| OMIM = 166945
| ECnumber =
| Homologene = 7438
| MGIid = 108498
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =  
  | Process =  
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4077
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001124650
    | Hs_RefseqmRNA = XM_001124650
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 17966
    | Mm_Ensembl = ENSMUSG00000017119
    | Mm_RefseqmRNA = NM_008676
    | Mm_RefseqProtein = NP_032702
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 101368239
    | Mm_GenLoc_end = 101398043
    | Mm_Uniprot = Q05BC8
  }}
}}
'''Neighbor of BRCA1 gene 1''', also known as '''NBR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077| accessdate = }}</ref>
| summary_text = The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.<ref name="entrez"/> One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.<ref>{{cite journal|last1=Kirkin|first1=Vladimir|title=A Role for Ubiquitin in Selective Autophagy|journal=Molecular Cell|date=2009|volume=34|doi= 10.1016/j.molcel.2009.04.026|pages=259–269}}</ref>
}}
}}
==Interactions==
NBR1 has been shown to [[Protein-protein interaction|interact]] with [[FEZ1]].<ref name=pmid11856312>{{cite journal |last=Whitehouse |first=Caroline |authorlink= |author2=Chambers Julie |author3=Howe Kathy |author4=Cobourne Martyn |author5=Sharpe Paul |author6=Solomon Ellen  |date=Jan 2002 |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue=2 |pages=538–545 |publisher= |location = Germany| issn = 0014-2956| pmid = 11856312 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.0014-2956.2001.02681.x }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Miki Y, Swensen J, Shattuck-Eidens D, ''et al.'' |title=A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. |journal=Science |volume=266 |issue= 5182 |pages= 66-71 |year= 1994 |pmid= 7545954 |doi=  }}
*{{cite journal  | author=Miki Y |title=A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 |journal=Science |volume=266 |issue= 5182 |pages= 66–71 |year= 1994 |pmid= 7545954 |doi=10.1126/science.7545954 |name-list-format=vanc| author2=Swensen J | author3=Shattuck-Eidens D  | display-authors=3  | last4=Futreal  | first4=P.  | last5=Harshman  | first5=K  | last6=Tavtigian  | first6=S | last7=Liu | first7=Q  | last8=Cochran  | first8=C  | last9=Bennett  | first9=L.  |bibcode=1994Sci...266...66M}}
*{{cite journal  | author=Harshman K, Bell R, Rosenthal J, ''et al.'' |title=Comparison of the positional cloning methods used to isolate the BRCA1 gene. |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1259-66 |year= 1995 |pmid= 7581362 |doi=  }}
*{{cite journal | author=Harshman K |title=Comparison of the positional cloning methods used to isolate the BRCA1 gene |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1259–1266 |year= 1995 |pmid= 7581362 |doi=10.1093/hmg/4.8.1259  |name-list-format=vanc| author2=Bell R  | author3=Rosenthal J  | display-authors=3  | last4=Katcher  | first4=Harold  | last5=Mlkl  | first5=Yoshio  | last6=Swenson | first6=Jeff  | last7=Gholami  | first7=Zahra  | last8=Frye  | first8=Cheryl  | last9=Ding  | first9=Wei }}
*{{cite journal | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi= }}
*{{cite journal  | author=Nomura N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–229 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |name-list-format=vanc| author2=Nagase T | author3=Miyajima N  | display-authors=3  | last4=Sazuka  | first4=T  | last5=Tanaka  | first5=A  | last6=Sato  | first6=S  | last7=Seki | first7=N  | last8=Kawarabayasi  | first8=Y  | last9=Ishikawa  | first9=K  }}
*{{cite journal  | author=Brown MA, Nicolai H, Xu CF, ''et al.'' |title=Regulation of BRCA1. |journal=Nature |volume=372 |issue= 6508 |pages= 733 |year= 1995 |pmid= 7997258 |doi= 10.1038/372733a0 }}
*{{cite journal  | author=Brown MA |title=Regulation of BRCA1 |journal=Nature |volume=372 |issue= 6508 |pages= 733–733 |year= 1995 |pmid= 7997258 |doi= 10.1038/372733a0  |name-list-format=vanc| author2=Nicolai H | author3=Xu CF  | display-authors=3  | last4=Griffiths  | first4=Beatrice L. | last5=Jones  | first5=Karen A. | last6=Solomon  | first6=Ellen  | last7=Hosking | first7=Louise  | last8=Trowsdale  | first8=John  | last9=Black | first9=Donald M. |bibcode=1994Natur.372..733B}}
*{{cite journal | author=Campbell IG, Nicolai HM, Foulkes WD, ''et al.'' |title=A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. |journal=Hum. Mol. Genet. |volume=3 |issue= 4 |pages= 589-94 |year= 1994 |pmid= 8069304 |doi=  }}
*{{cite journal  | author=Brown MA |title=The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 |journal=Oncogene |volume=12 |issue= 12 |pages= 2507–13 |year= 1996 |pmid= 8700509 |doi=  |name-list-format=vanc| author2=Xu CF  | author3=Nicolai H | display-authors=3  | last4=Griffiths  | first4=B  | last5=Chambers  | first5=JA  | last6=Black  | first6=D  | last7=Solomon  | first7=E  }}
*{{cite journal  | author=Brown MA, Xu CF, Nicolai H, ''et al.'' |title=The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. |journal=Oncogene |volume=12 |issue= 12 |pages= 2507-13 |year= 1996 |pmid= 8700509 |doi=  }}
*{{cite journal  |vauthors=Dimitrov S, Brennerova M, Forejt J |title=Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes |journal=Gene |volume=262 |issue= 1–2 |pages= 89–98 |year= 2001 |pmid= 11179671 |doi=10.1016/S0378-1119(00)00549-7  }}
*{{cite journal | author=Dimitrov S, Brennerova M, Forejt J |title=Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. |journal=Gene |volume=262 |issue= 1-2 |pages= 89-98 |year= 2001 |pmid= 11179671 |doi= }}
*{{cite journal  | author=Whitehouse C |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–545 |year= 2002 |pmid= 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |name-list-format=vanc| author2=Chambers J  | author3=Howe K  | display-authors=3  | last4=Cobourne  | first4=Martyn  | last5=Sharpe  | first5=Paul  | last6=Solomon  | first6=Ellen  }}
*{{cite journal | author=Whitehouse C, Chambers J, Howe K, ''et al.'' |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538-45 |year= 2002 |pmid= 11856312 |doi= }}
*{{cite journal  | author=Wistow G |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium |journal=Mol. Vis. |volume=8 |issue=  |pages= 185–95 |year= 2002 |pmid= 12107412 |doi=  |name-list-format=vanc| author2=Bernstein SL  | author3=Ray S  | display-authors=3  | last4=Wyatt  | first4=MK  | last5=Behal  | first5=A  | last6=Touchman  | first6=JW  | last7=Bouffard  | first7=G  | last8=Smith  | first8=D  | last9=Peterson  | first9=K  }}
*{{cite journal | author=Wistow G, Bernstein SL, Ray S, ''et al.'' |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue=  |pages= 185-95 |year= 2002 |pmid= 12107412 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Lamark T |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568–34581 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200  |name-list-format=vanc| author2=Perander M  | author3=Outzen H  | display-authors=3  | last4=Kristiansen  | first4=K  | last5=Øvervatn  | first5=A  | last6=Michaelsen  | first6=E  | last7=Bjørkøy  | first7=G  | last8=Johansen  | first8=T }}
*{{cite journal | author=Lamark T, Perander M, Outzen H, ''et al.'' |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568-81 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lange S |title=The kinase domain of titin controls muscle gene expression and protein turnover |journal=Science |volume=308 |issue= 5728 |pages= 1599–1603 |year= 2005 |pmid= 15802564 |doi= 10.1126/science.1110463  |name-list-format=vanc| author2=Xiang F  | author3=Yakovenko A  | display-authors=3  | last4=Vihola  | first4=A  | last5=Hackman  | first5=P  | last6=Rostkova  | first6=E  | last7=Kristensen  | first7=J  | last8=Brandmeier  | first8=B  | last9=Franzen  | first9=G |bibcode=2005Sci...308.1599L}}
*{{cite journal | author=Lange S, Xiang F, Yakovenko A, ''et al.'' |title=The kinase domain of titin controls muscle gene expression and protein turnover. |journal=Science |volume=308 |issue= 5728 |pages= 1599-603 |year= 2005 |pmid= 15802564 |doi= 10.1126/science.1110463 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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{{PDB Gallery|geneid=4077}}
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[[Category:Human proteins]]


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Latest revision as of 15:03, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[1][2]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[3]

Interactions

NBR1 has been shown to interact with FEZ1.[4]

References

  1. ↑ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
  2. ↑ 2.0 2.1 "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
  3. ↑ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34: 259–269. doi:10.1016/j.molcel.2009.04.026.
  4. ↑ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. Germany. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading


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