NLRP7: Difference between revisions

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Latest revision as of 13:05, 5 September 2017

NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.^[1]^[2]^[3]

Function

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.^[3]

References

↑ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
↑ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
↑ ^3.0 ^3.1 "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7".

Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759.
Moglabey YB, Kircheisen R, Seoud M, et al. (1999). "Genetic mapping of a maternal locus responsible for familial hydatidiform moles". Hum. Mol. Genet. 8 (4): 667–71. doi:10.1093/hmg/8.4.667. PMID 10072436.
Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Okada K, Hirota E, Mizutani Y, et al. (2005). "Oncogenic role of NALP7 in testicular seminomas". Cancer Sci. 95 (12): 949–54. doi:10.1111/j.1349-7006.2004.tb03182.x. PMID 15596043.
Kinoshita T, Wang Y, Hasegawa M, et al. (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion". J. Biol. Chem. 280 (23): 21720–5. doi:10.1074/jbc.M410057200. PMID 15817483.
Murdoch S, Djuric U, Mazhar B, et al. (2006). "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans". Nat. Genet. 38 (3): 300–2. doi:10.1038/ng1740. PMID 16462743.
Bestor TH, Bourc'his D (2006). "Genetics and epigenetics of hydatidiform moles". Nat. Genet. 38 (3): 274–6. doi:10.1038/ng0306-274. PMID 16501554.
Djuric U, El-Maarri O, Lamb B, et al. (2007). "Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation". Hum. Genet. 120 (3): 390–5. doi:10.1007/s00439-006-0192-3. PMID 16874523.
Qian J, Deveault C, Bagga R, et al. (2007). "Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations". Hum. Mutat. 28 (7): 741. doi:10.1002/humu.9498. PMID 17579354.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid12563287-1] Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.

[pmid12019269-2] Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.

[entrez-3] 3.0 ^3.1 "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''NACHT, LRR and PYD domains-containing protein 7''' is a [[protein]] that in humans is encoded by the ''NLRP7'' [[gene]].<ref name="pmid12563287">{{cite journal | vauthors = Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | pmc =  | doi = 10.1038/nrm1019 }}</ref><ref name="pmid12019269">{{cite journal | vauthors = Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | pmc =  | doi = 10.1074/jbc.M203915200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP7 NLR family, pyrin domain containing 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713| accessdate = }}</ref>
+== Function ==
+NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an [[N-terminus|N-terminal]] pyrin ([[MEFV]]) domain (PYD), followed by a [[NACHT domain]], a NACHT-associated domain (NAD), and a [[C-terminus|C-terminal]] leucine-rich repeat ([[leucine-rich repeat|LRR]]) region. NALPs are implicated in the activation of proinflammatory [[caspase]]s (e.g., [[CASP1]]) via their involvement in multiprotein complexes called [[inflammasome]]s.<ref name="entrez" />
+==References==
+{{reflist}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | vauthors=Inohara N, Nuñez G |title=NODs: intracellular proteins involved in inflammation and apoptosis. |journal=Nat. Rev. Immunol. |volume=3 |issue= 5 |pages= 371–82 |year= 2003 |pmid= 12766759 |doi= 10.1038/nri1086 }}
+*{{cite journal   |vauthors=Moglabey YB, Kircheisen R, Seoud M, etal |title=Genetic mapping of a maternal locus responsible for familial hydatidiform moles. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 667–71 |year= 1999 |pmid= 10072436 |doi=10.1093/hmg/8.4.667  }}
+*{{cite journal   |vauthors=Grenier JM, Wang L, Manji GA, etal |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
+*{{cite journal   |vauthors=Okada K, Hirota E, Mizutani Y, etal |title=Oncogenic role of NALP7 in testicular seminomas. |journal=Cancer Sci. |volume=95 |issue= 12 |pages= 949–54 |year= 2005 |pmid= 15596043 |doi=10.1111/j.1349-7006.2004.tb03182.x  }}
+*{{cite journal   |vauthors=Kinoshita T, Wang Y, Hasegawa M, etal |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720–5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 }}
+*{{cite journal   |vauthors=Murdoch S, Djuric U, Mazhar B, etal |title=Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 300–2 |year= 2006 |pmid= 16462743 |doi= 10.1038/ng1740 }}
+*{{cite journal  | vauthors=Bestor TH, Bourc'his D |title=Genetics and epigenetics of hydatidiform moles. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 274–6 |year= 2006 |pmid= 16501554 |doi= 10.1038/ng0306-274 }}
+*{{cite journal   |vauthors=Djuric U, El-Maarri O, Lamb B, etal |title=Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. |journal=Hum. Genet. |volume=120 |issue= 3 |pages= 390–5 |year= 2007 |pmid= 16874523 |doi= 10.1007/s00439-006-0192-3 }}
+*{{cite journal   |vauthors=Qian J, Deveault C, Bagga R, etal |title=Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations. |journal=Hum. Mutat. |volume=28 |issue= 7 |pages= 741 |year= 2007 |pmid= 17579354 |doi= 10.1002/humu.9498 }}
+}}
+{{refend}}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
 {{PBB_Controls
@@ Line 4: / Line 33: @@
 | require_manual_inspection = no
 | update_protein_box = yes
-| update_summary = yes
+| update_summary = no
 | update_citations = yes
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{NOD-like receptors}}
-{{GNF_Protein_box
- | image =
+[[Category:LRR proteins]]
- | image_source =
+[[Category:NOD-like receptors]]
- | PDB =
- | Name = NLR family, pyrin domain containing 7
- | HGNCid = 22947
- | Symbol = NLRP7
- | AltSymbols =; CLR19.4; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3
- | OMIM = 609661
- | ECnumber =
- | Homologene = 51401
- | MGIid =
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006952 |text = defense response}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 199713
-    | Hs_Ensembl = ENSG00000167634
-    | Hs_RefseqProtein = NP_631915
-    | Hs_RefseqmRNA = NM_139176
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 60126689
-    | Hs_GenLoc_end = 60150679
-    | Hs_Uniprot = Q8WX94
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''NLR family, pyrin domain containing 7''', also known as '''NLRP7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NLRP7 NLR family, pyrin domain containing 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NLRP7 NLR family, pyrin domain containing 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713| accessdate = }}</ref>
-}}
-==References==
+{{gene-19-stub}}
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Tschopp J, Martinon F, Burns K |title=NALPs: a novel protein family involved in inflammation. |journal=Nat. Rev. Mol. Cell Biol. |volume=4 |issue= 2 |pages= 95-104 |year= 2003 |pmid= 12563287 |doi= 10.1038/nrm1019 }}
-*{{cite journal  | author=Inohara N, Nuñez G |title=NODs: intracellular proteins involved in inflammation and apoptosis. |journal=Nat. Rev. Immunol. |volume=3 |issue= 5 |pages= 371-82 |year= 2003 |pmid= 12766759 |doi= 10.1038/nri1086 }}
-*{{cite journal  | author=Moglabey YB, Kircheisen R, Seoud M, ''et al.'' |title=Genetic mapping of a maternal locus responsible for familial hydatidiform moles. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 667-71 |year= 1999 |pmid= 10072436 |doi=  }}
-*{{cite journal  | author=Wang L, Manji GA, Grenier JM, ''et al.'' |title=PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29874-80 |year= 2002 |pmid= 12019269 |doi= 10.1074/jbc.M203915200 }}
-*{{cite journal  | author=Grenier JM, Wang L, Manji GA, ''et al.'' |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 73-8 |year= 2002 |pmid= 12387869 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
-*{{cite journal  | author=Okada K, Hirota E, Mizutani Y, ''et al.'' |title=Oncogenic role of NALP7 in testicular seminomas. |journal=Cancer Sci. |volume=95 |issue= 12 |pages= 949-54 |year= 2005 |pmid= 15596043 |doi=  }}
-*{{cite journal  | author=Kinoshita T, Wang Y, Hasegawa M, ''et al.'' |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720-5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 }}
-*{{cite journal  | author=Murdoch S, Djuric U, Mazhar B, ''et al.'' |title=Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 300-2 |year= 2006 |pmid= 16462743 |doi= 10.1038/ng1740 }}
-*{{cite journal  | author=Bestor TH, Bourc'his D |title=Genetics and epigenetics of hydatidiform moles. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 274-6 |year= 2006 |pmid= 16501554 |doi= 10.1038/ng0306-274 }}
-*{{cite journal  | author=Djuric U, El-Maarri O, Lamb B, ''et al.'' |title=Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. |journal=Hum. Genet. |volume=120 |issue= 3 |pages= 390-5 |year= 2007 |pmid= 16874523 |doi= 10.1007/s00439-006-0192-3 }}
-*{{cite journal  | author=Qian J, Deveault C, Bagga R, ''et al.'' |title=Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations. |journal=Hum. Mutat. |volume=28 |issue= 7 |pages= 741 |year= 2007 |pmid= 17579354 |doi= 10.1002/humu.9498 }}
-}}
-{{refend}}
-[[Category:LRR proteins]]
-{{protein-stub}}
-{{WikiDoc Sources}}

v t e NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

NLRP7: Difference between revisions

Latest revision as of 13:05, 5 September 2017

Function

References

Further reading

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