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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Neural proliferation differentiation and control protein 1''' is a [[protein]] that in humans is encoded by the ''NPDC1'' [[gene]].<ref name="pmid11245976">{{cite journal | vauthors = Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F | title = Characterization and tissue expression of a novel human gene npdc1 | journal = Gene | volume = 264 | issue = 1 | pages = 37–44  | date = March 2001 | pmid = 11245976 | pmc =  | doi = 10.1016/S0378-1119(01)00324-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56654| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Neural proliferation, differentiation and control, 1
| HGNCid = 7899
| Symbol = NPDC1
| AltSymbols =; CAB1; CAB; CAB-; CAB-1; DKFZP586J0523
| OMIM = 605798
| ECnumber = 
| Homologene = 32050
| MGIid = 1099802
| GeneAtlas_image1 = PBB_GE_NPDC1_218086_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56654
    | Hs_Ensembl = ENSG00000107281
    | Hs_RefseqProtein = NP_056207
    | Hs_RefseqmRNA = NM_015392
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 139053743
    | Hs_GenLoc_end = 139060476
    | Hs_Uniprot = Q9NQX5
    | Mm_EntrezGene = 18146
    | Mm_Ensembl = ENSMUSG00000015094
    | Mm_RefseqmRNA = NM_008721
    | Mm_RefseqProtein = NP_032747
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 25225092
    | Mm_GenLoc_end = 25231503
    | Mm_Uniprot = Q925Q2
  }}
}}
'''Neural proliferation, differentiation and control, 1''', also known as '''NPDC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56654| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
NPDC1 has been shown to [[Protein-protein interaction|interact]] with [[E2F1]].<ref name=pmid11042687>{{cite journal | vauthors = Sansal I, Dupont E, Toru D, Evrard C, Rouget P | title = NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity | journal = Oncogene | volume = 19 | issue = 43 | pages = 5000–9  | date = October 2000 | pmid = 11042687 | doi = 10.1038/sj.onc.1203843 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dupont E, Sansal I, Toru D, Evrard C, Rouget P | title = [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors] | journal = C. R. Séances Soc. Biol. Fil. | volume = 191 | issue = 1 | pages = 95–104 | year = 1997 | pmid = 9181131 | doi =  }}
| citations =
* {{cite journal | vauthors = Galiana E, Vernier P, Dupont E, Evrard C, Rouget P | title = Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 5 | pages = 1560–4 | year = 1995 | pmid = 7878019 | pmc = 42559 | doi = 10.1073/pnas.92.5.1560 }}
*{{cite journal | author=Dupont E, Sansal I, Toru D, ''et al.'' |title=[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors] |journal=C. R. Seances Soc. Biol. Fil. |volume=191 |issue= 1 |pages= 95-104 |year= 1997 |pmid= 9181131 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Galiana E, Vernier P, Dupont E, ''et al.'' |title=Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1560-4 |year= 1995 |pmid= 7878019 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Iwasaki K, Toyonaga R | title = The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission | journal = EMBO J. | volume = 19 | issue = 17 | pages = 4806–16 | year = 2000 | pmid = 10970871 | pmc = 302062 | doi = 10.1093/emboj/19.17.4806 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Sansal I, Dupont E, Toru D, Evrard C, Rouget P | title = NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity | journal = Oncogene | volume = 19 | issue = 43 | pages = 5000–9 | year = 2000 | pmid = 11042687 | doi = 10.1038/sj.onc.1203843 }}
*{{cite journal | author=Iwasaki K, Toyonaga R |title=The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4806-16 |year= 2000 |pmid= 10970871 |doi= 10.1093/emboj/19.17.4806 }}
* {{cite journal | vauthors = Spencer ML, Theodosiou M, Noonan DJ | title = NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif | journal = J. Biol. Chem. | volume = 279 | issue = 35 | pages = 37069–78 | year = 2004 | pmid = 15229225 | doi = 10.1074/jbc.M402507200 }}
*{{cite journal | author=Sansal I, Dupont E, Toru D, ''et al.'' |title=NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. |journal=Oncogene |volume=19 |issue= 43 |pages= 5000-9 |year= 2000 |pmid= 11042687 |doi= 10.1038/sj.onc.1203843 }}
* {{cite journal | vauthors = Evrard C, Caron S, Rouget P | title = Functional analysis of the NPDC-1 gene | journal = Gene | volume = 343 | issue = 1 | pages = 153–63 | year = 2004 | pmid = 15563841 | doi = 10.1016/j.gene.2004.08.020 }}
*{{cite journal | author=Qu X, Zhang C, Zhai Y, ''et al.'' |title=Characterization and tissue expression of a novel human gene npdc1. |journal=Gene |volume=264 |issue= 1 |pages= 37-44 |year= 2001 |pmid= 11245976 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Spencer ML, Theodosiou M, Noonan DJ |title=NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 37069-78 |year= 2004 |pmid= 15229225 |doi= 10.1074/jbc.M402507200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Evrard C, Caron S, Rouget P |title=Functional analysis of the NPDC-1 gene. |journal=Gene |volume=343 |issue= 1 |pages= 153-63 |year= 2005 |pmid= 15563841 |doi= 10.1016/j.gene.2004.08.020 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 07:38, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.[1][2]

Interactions

NPDC1 has been shown to interact with E2F1.[3]

References

  1. ↑ Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene. 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976.
  2. ↑ "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".
  3. ↑ Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.

Further reading


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