OPCML: Difference between revisions

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Latest revision as of 17:40, 5 December 2018

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.^[1]^[2]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.^[2]

References

↑ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.
↑ ^2.0 ^2.1 "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

Lane CM, Elde R, Loh HH, Lee NM (1993). "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (23): 11234–8. doi:10.1073/pnas.89.23.11234. PMC 50524. PMID 1333602.
Shark KB, Lee NM (1995). "Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM)". Gene. 155 (2): 213–7. doi:10.1016/0378-1119(94)00830-L. PMID 7721093.
Struyk AF, Canoll PD, Wolfgang MJ, et al. (1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J. Neurosci. 15 (3 Pt 2): 2141–56. PMID 7891157.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mei FC, Young TW, Liu J, Cheng X (2006). "RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells". FASEB J. 20 (3): 497–9. doi:10.1096/fj.05-4586fje. PMID 16384911.
Wang L, Zhu JS, Song MQ, et al. (2007). "Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray". World J. Gastroenterol. 12 (43): 6949–54. PMID 17109515.
Czekierdowski A, Czekierdowska S, Szymanski M, et al. (2007). "Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer". Neuro Endocrinol. Lett. 27 (5): 609–13. PMID 17159813.
Reed JE, Dunn JR, du Plessis DG, et al. (2007). "Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours". Neuropathol. Appl. Neurobiol. 33 (1): 77–85. doi:10.1111/j.1365-2990.2006.00786.x. PMID 17239010.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid8244387-1] Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.

[entrez-2] 2.0 ^2.1 "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Opioid-binding protein/cell adhesion molecule''' is a [[protein]] that in humans is encoded by the ''OPCML'' [[gene]].<ref name="pmid8244387">{{cite journal | vauthors = Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y| title = A sequence-tagged site map of human chromosome 11 | journal = Genomics | volume = 17 | issue = 3 | pages = 699–725 |date=Dec 1993 | pmid = 8244387 | pmc =  | doi =10.1006/geno.1993.1392  |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4978| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Opioid binding protein/cell adhesion molecule-like
- | HGNCid = 8143
- | Symbol = OPCML
- | AltSymbols =; OBCAM; OPCM
- | OMIM = 600632
- | ECnumber =
- | Homologene = 55663
- | MGIid = 97397
- | GeneAtlas_image1 = PBB_GE_OPCML_206215_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004985 |text = opioid receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008038 |text = neuron recognition}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4978
-    | Hs_Ensembl = ENSG00000183715
-    | Hs_RefseqProtein = NP_001012393
-    | Hs_RefseqmRNA = NM_001012393
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 131795297
-    | Hs_GenLoc_end = 132907429
-    | Hs_Uniprot = Q14982
-    | Mm_EntrezGene = 330908
-    | Mm_Ensembl = ENSMUSG00000062257
-    | Mm_RefseqmRNA = NM_177906
-    | Mm_RefseqProtein = NP_808574
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 27540832
-    | Mm_GenLoc_end = 28669633
-    | Mm_Uniprot =
-  }}
-}}
-'''Opioid binding protein/cell adhesion molecule-like''', also known as '''OPCML''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4978| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4978| accessdate = }}</ref>
+| summary_text = This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Lane CM, Elde R, Loh HH, Lee NM |title=Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 23 |pages= 11234-8 |year= 1993 |pmid= 1333602 |doi=  }}
+*{{cite journal|authorlink3=Harold Loh  | vauthors=Lane CM, Elde R, Loh HH, Lee NM |title=Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 23 |pages= 11234–8 |year= 1993 |pmid= 1333602 |doi=10.1073/pnas.89.23.11234  | pmc=50524  }}
-*{{cite journal  | author=Shark KB, Lee NM |title=Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). |journal=Gene |volume=155 |issue= 2 |pages= 213-7 |year= 1995 |pmid= 7721093 |doi=  }}
+*{{cite journal  | vauthors=Shark KB, Lee NM |title=Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM) |journal=Gene |volume=155 |issue= 2 |pages= 213–7 |year= 1995 |pmid= 7721093 |doi=10.1016/0378-1119(94)00830-L  }}
-*{{cite journal  | author=Struyk AF, Canoll PD, Wolfgang MJ, ''et al.'' |title=Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. |journal=J. Neurosci. |volume=15 |issue= 3 Pt 2 |pages= 2141-56 |year= 1995 |pmid= 7891157 |doi=  }}
+*{{cite journal   |vauthors=Struyk AF, Canoll PD, Wolfgang MJ, etal |title=Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules |journal=J. Neurosci. |volume=15 |issue= 3 Pt 2 |pages= 2141–56 |year= 1995 |pmid= 7891157 |doi=  }}
-*{{cite journal  | author=Smith MW, Clark SP, Hutchinson JS, ''et al.'' |title=A sequence-tagged site map of human chromosome 11. |journal=Genomics |volume=17 |issue= 3 |pages= 699-725 |year= 1993 |pmid= 8244387 |doi=  }}
+*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
-*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
+*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Sellar GC, Watt KP, Rabiasz GJ, etal |title=OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer |journal=Nat. Genet. |volume=34 |issue= 3 |pages= 337–43 |year= 2003 |pmid= 12819783 |doi= 10.1038/ng1183 }}
-*{{cite journal  | author=Sellar GC, Watt KP, Rabiasz GJ, ''et al.'' |title=OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. |journal=Nat. Genet. |volume=34 |issue= 3 |pages= 337-43 |year= 2003 |pmid= 12819783 |doi= 10.1038/ng1183 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Schmitt-Ulms G, Hansen K, Liu J, etal |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724–31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 }}
-*{{cite journal  | author=Schmitt-Ulms G, Hansen K, Liu J, ''et al.'' |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724-31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Mei FC, Young TW, Liu J, Cheng X |title=RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells |journal=FASEB J. |volume=20 |issue= 3 |pages= 497–9 |year= 2006 |pmid= 16384911 |doi= 10.1096/fj.05-4586fje }}
-*{{cite journal  | author=Mei FC, Young TW, Liu J, Cheng X |title=RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. |journal=FASEB J. |volume=20 |issue= 3 |pages= 497-9 |year= 2006 |pmid= 16384911 |doi= 10.1096/fj.05-4586fje }}
+*{{cite journal   |vauthors=Wang L, Zhu JS, Song MQ, etal |title=Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray |journal=World J. Gastroenterol. |volume=12 |issue= 43 |pages= 6949–54 |year= 2007 |pmid= 17109515 |doi=  }}
-*{{cite journal  | author=Wang L, Zhu JS, Song MQ, ''et al.'' |title=Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray. |journal=World J. Gastroenterol. |volume=12 |issue= 43 |pages= 6949-54 |year= 2007 |pmid= 17109515 |doi=  }}
+*{{cite journal   |vauthors=Czekierdowski A, Czekierdowska S, Szymanski M, etal |title=Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer |journal=Neuro Endocrinol. Lett. |volume=27 |issue= 5 |pages= 609–13 |year= 2007 |pmid= 17159813 |doi=  }}
-*{{cite journal  | author=Czekierdowski A, Czekierdowska S, Szymanski M, ''et al.'' |title=Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer. |journal=Neuro Endocrinol. Lett. |volume=27 |issue= 5 |pages= 609-13 |year= 2007 |pmid= 17159813 |doi=  }}
+*{{cite journal   |vauthors=Reed JE, Dunn JR, du Plessis DG, etal |title=Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours |journal=Neuropathol. Appl. Neurobiol. |volume=33 |issue= 1 |pages= 77–85 |year= 2007 |pmid= 17239010 |doi= 10.1111/j.1365-2990.2006.00786.x }}
-*{{cite journal  | author=Reed JE, Dunn JR, du Plessis DG, ''et al.'' |title=Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours. |journal=Neuropathol. Appl. Neurobiol. |volume=33 |issue= 1 |pages= 77-85 |year= 2007 |pmid= 17239010 |doi= 10.1111/j.1365-2990.2006.00786.x }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-11-stub}}

OPCML: Difference between revisions

Latest revision as of 17:40, 5 December 2018

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