OS9 (gene): Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein OS-9''' is a [[protein]] that in humans is encoded by the ''OS9'' [[gene]].<ref name="pmid8634085">{{cite journal | vauthors = Su YA, Hutter CM, Trent JM, Meltzer PS | title = Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas | journal = Molecular Carcinogenesis | volume = 15 | issue = 4 | pages = 270–5 | date = Apr 1996 | pmid = 8634085 | pmc =  | doi = 10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K }}</ref><ref name="pmid9498564">{{cite journal | vauthors = Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M | title = Genomic organization of the OS-9 gene amplified in human sarcomas | journal = Journal of Biochemistry | volume = 122 | issue = 6 | pages = 1190–5 | date = Dec 1997 | pmid = 9498564 | pmc =  | doi = 10.1093/oxfordjournals.jbchem.a021880 }}</ref><ref name="pmid19346256">{{cite journal | vauthors = Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K | title = Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans | journal = The Journal of Biological Chemistry | volume = 284 | issue = 25 | pages = 17061–8 | date = Jun 2009 | pmid = 19346256 | pmc = 2719344 | doi = 10.1074/jbc.M809725200 }}</ref><ref name="pmid18264092">{{cite journal | vauthors = Christianson JC, Shaler TA, Tyler RE, Kopito RR | title = OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD | journal = Nature Cell Biology | volume = 10 | issue = 3 | pages = 272–82 | date = Mar 2008 | pmid = 18264092 | pmc = 2757077 | doi = 10.1038/ncb1689 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OS9 amplified in osteosarcoma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10956| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Amplified in osteosarcoma
| HGNCid = 
| Symbol = OS9
| AltSymbols =;
| OMIM = 609677
| ECnumber = 
| Homologene = 31409
| MGIid = 1924301
| GeneAtlas_image1 = PBB_GE_OS9_215399_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OS9_200714_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10956
    | Hs_Ensembl = ENSG00000135506
    | Hs_RefseqProtein = NP_001017956
    | Hs_RefseqmRNA = NM_001017956
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 56374153
    | Hs_GenLoc_end = 56401605
    | Hs_Uniprot = Q13438
    | Mm_EntrezGene = 216440
    | Mm_Ensembl = ENSMUSG00000040462
    | Mm_RefseqmRNA = NM_177614
    | Mm_RefseqProtein = NP_808282
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 126498601
    | Mm_GenLoc_end = 126524080
    | Mm_Uniprot = 
  }}
}}
'''Amplified in osteosarcoma''', also known as '''OS9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OS9 amplified in osteosarcoma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10956| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: OS9 amplified in osteosarcoma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10956| accessdate = }}</ref>
}}


==References==
== Model organisms ==
{{reflist|2}}
 
==Further reading==
[[Model organism]]s have been used in the study of OS9 function. A conditional [[knockout mouse]] line called ''Os9<sup>tm1a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Os9#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Os9&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Os9'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />{
|-
| Insulin || bgcolor="#488ED3"|Normal
 
|-
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
 
|-
| Homozygous Fertility || bgcolor="#488ED3"|Normal
 
|-
| General Observations || bgcolor="#C40000"|Abnormal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Anti-nuclear Antibody Assay || bgcolor="#488ED3"|Normal
 
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
 
|-
| Influenza Challenge || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear|left}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
| citations =
* {{cite journal | vauthors = Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL | title = OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha | journal = Molecular Cell | volume = 17 | issue = 4 | pages = 503–12 | date = Feb 2005 | pmid = 15721254 | doi = 10.1016/j.molcel.2005.01.011 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Baek JH, Mahon PC, Oh J, ''et al.'' |title=OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. |journal=Mol. Cell |volume=17 |issue= 4 |pages= 503-12 |year= 2005 |pmid= 15721254 |doi= 10.1016/j.molcel.2005.01.011 }}
* {{cite journal | vauthors = Vigneron N, Ooms A, Morel S, Degiovanni G, Van Den Eynde BJ | title = Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma | journal = Cancer Immunity | volume = 2 | issue =  | pages = 9 | date = Jul 2002 | pmid = 12747754 | doi =  }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Litovchick L, Friedmann E, Shaltiel S | title = A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 34413–23 | date = Sep 2002 | pmid = 12093806 | doi = 10.1074/jbc.M203986200 }}
*{{cite journal | author=Vigneron N, Ooms A, Morel S, ''et al.'' |title=Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma. |journal=Cancer Immun. |volume=2 |issue=  |pages= 9 |year= 2003 |pmid= 12747754 |doi=  }}
* {{cite journal | vauthors = Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE | title = YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 38 | pages = 35274–81 | date = Sep 2002 | pmid = 12077121 | doi = 10.1074/jbc.M201044200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T | title = Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma | journal = FEBS Letters | volume = 453 | issue = 1-2 | pages = 77–80 | date = Jun 1999 | pmid = 10403379 | doi = 10.1016/S0014-5793(99)00700-0 }}
*{{cite journal  | author=Litovchick L, Friedmann E, Shaltiel S |title=A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34413-23 |year= 2002 |pmid= 12093806 |doi= 10.1074/jbc.M203986200 }}
* {{cite journal | vauthors = Kimura Y, Nakazawa M, Yamada M | title = Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines | journal = Journal of Biochemistry | volume = 123 | issue = 5 | pages = 876–82 | date = May 1998 | pmid = 9562620 | doi = 10.1093/oxfordjournals.jbchem.a022019 }}
*{{cite journal | author=Friedmann E, Salzberg Y, Weinberger A, ''et al.'' |title=YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35274-81 |year= 2002 |pmid= 12077121 |doi= 10.1074/jbc.M201044200 }}
* {{cite journal | vauthors = Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS | title = Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers | journal = Genomics | volume = 42 | issue = 2 | pages = 295–301 | date = Jun 1997 | pmid = 9192850 | doi = 10.1006/geno.1997.4727 }}
*{{cite journal | author=Nakayama T, Yaoi T, Kuwajima G, ''et al.'' |title=Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. |journal=FEBS Lett. |volume=453 |issue= 1-2 |pages= 77-80 |year= 1999 |pmid= 10403379 |doi= }}
*{{cite journal | author=Kimura Y, Nakazawa M, Yamada M |title=Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. |journal=J. Biochem. |volume=123 |issue= 5 |pages= 876-82 |year= 1998 |pmid= 9562620 |doi= }}
*{{cite journal  | author=Kimura Y, Nakazawa M, Tsuchiya N, ''et al.'' |title=Genomic organization of the OS-9 gene amplified in human sarcomas. |journal=J. Biochem. |volume=122 |issue= 6 |pages= 1190-5 |year= 1998 |pmid= 9498564 |doi=  }}
*{{cite journal | author=Elkahloun AG, Krizman DB, Wang Z, ''et al.'' |title=Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. |journal=Genomics |volume=42 |issue= 2 |pages= 295-301 |year= 1997 |pmid= 9192850 |doi= 10.1006/geno.1997.4727 }}
*{{cite journal  | author=Su YA, Hutter CM, Trent JM, Meltzer PS |title=Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. |journal=Mol. Carcinog. |volume=15 |issue= 4 |pages= 270-5 |year= 1996 |pmid= 8634085 |doi= 10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Proteins]]
{{WikiDoc Sources}}
[[Category:Genes]]

Latest revision as of 00:35, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.[1][2][3][4][5]

Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

Model organisms

Model organisms have been used in the study of OS9 function. A conditional knockout mouse line called Os9tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]

References

  1. ↑ Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085.
  2. ↑ Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
  3. ↑ Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344. PMID 19346256.
  4. ↑ Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.
  5. ↑ 5.0 5.1 "Entrez Gene: OS9 amplified in osteosarcoma".
  6. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. ↑ 7.0 7.1 "International Mouse Phenotyping Consortium".
  8. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  12. ↑ 12.0 12.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL (Feb 2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Molecular Cell. 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Vigneron N, Ooms A, Morel S, Degiovanni G, Van Den Eynde BJ (Jul 2002). "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma". Cancer Immunity. 2: 9. PMID 12747754.
  • Litovchick L, Friedmann E, Shaltiel S (Sep 2002). "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta". The Journal of Biological Chemistry. 277 (37): 34413–23. doi:10.1074/jbc.M203986200. PMID 12093806.
  • Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE (Sep 2002). "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins". The Journal of Biological Chemistry. 277 (38): 35274–81. doi:10.1074/jbc.M201044200. PMID 12077121.
  • Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T (Jun 1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Letters. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379.
  • Kimura Y, Nakazawa M, Yamada M (May 1998). "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines". Journal of Biochemistry. 123 (5): 876–82. doi:10.1093/oxfordjournals.jbchem.a022019. PMID 9562620.
  • Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (Jun 1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Retrieved from "https://www.wikidoc.org/index.php?title=OS9_(gene)&oldid=1415829"