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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Oviduct-specific glycoprotein''' also known as '''oviductal glycoprotein''' (OGP) or '''estrogen-dependent oviduct protein''' (EGP) or '''mucin-9''' (MUC9) is a [[protein]] that in humans is encoded by the ''OVGP1'' [[gene]].<ref name="pmid7819450">{{cite journal |vauthors=Arias EB, Verhage HG, Jaffe RC | title = Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein | journal = Biol Reprod | volume = 51 | issue = 4 | pages = 685–94 |date=Feb 1995 | pmid = 7819450 | pmc =  | doi =10.1095/biolreprod51.4.685  }}</ref><ref name="pmid9341614">{{cite journal |vauthors=Lapensee L, Paquette Y, Bleau G | title = Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9) | journal = Fertil Steril | volume = 68 | issue = 4 | pages = 702–8 |date=Nov 1997 | pmid = 9341614 | pmc =  | doi =10.1016/S0015-0282(97)00317-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)
| HGNCid = 8524
| Symbol = OVGP1
| AltSymbols =; EGP; CHIT5; MUC9; OGP
| OMIM = 603578
| ECnumber = 
| Homologene = 74442
| MGIid = 106661
| GeneAtlas_image1 = PBB_GE_OVGP1_205432_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004568 |text = chitinase activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006032 |text = chitin catabolic process}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5016
    | Hs_Ensembl = ENSG00000085465
    | Hs_RefseqProtein = NP_002548
    | Hs_RefseqmRNA = NM_002557
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 111758459
    | Hs_GenLoc_end = 111771922
    | Hs_Uniprot = Q12889
    | Mm_EntrezGene = 12659
    | Mm_Ensembl = ENSMUSG00000074340
    | Mm_RefseqmRNA = NM_007696
    | Mm_RefseqProtein = NP_031722
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 106101858
    | Mm_GenLoc_end = 106115479
    | Mm_Uniprot = Q54AJ4
  }}
}}
'''Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)''', also known as '''OVGP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Oviduct-specific glycoprotein is a large, carbohydrate-rich, [[epithelium|epithelial]] [[glycoprotein]] with numerous O-glycosylation sites located within [[threonine]], [[serine]], and [[proline]]-rich tandem repeats. The gene is similar to members of the [[mucin]] and the [[List of glycoside hydrolase families#Family 18|glycosyl hydrolase 18]] gene families. Regulation of expression may be [[estrogen]]-dependent. Gene expression and protein secretion occur during late [[ovarian follicle|follicular]] development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated [[oviduct]]al epithelial cells and associates with ovulated [[oocyte]]s, [[blastomere]]s, and spermatozoon [[acrosome|acrosomal]] regions.<ref name="entrez"/>
{{PBB_Summary
Beyond the [[oviduct]], OVGP1 is detected in the mouse [[ovary]], [[testis]] and [[epididymis]] suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland <ref>{{cite journal |last1=Laheri |first1=Saniya |last2=Modi |first2=Deepak |last3=Bhatt |first3=Purvi |title=Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary. |journal=Journal of Biosciences |date=Mar 2017 |volume=42 |issue=1 |pages=69–80 |pmid=28229966 |url=https://www.ias.ac.in/article/fulltext/jbsc/042/01/0069-0080 |accessdate=16 July 2018}}</ref>
| section_title =
OVGP1 is expressed by the surface epithelium of the [[endometrium]] at the time of [[embryo implantation]] in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with [[recurrent implantation failure]] <ref>{{cite journal |last1=Laheri |first1=Saniya |last2=Ashary |first2=Nancy |last3=Bhatt |first3=Purvi |last4=Modi |first4=Deepak |title=Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion |journal=Journal of Assisted Reproduction and Genetics |doi=10.1007/s10815-018-1231-4 |pmid=29968069 }}</ref>
| summary_text = This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.<ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
*{{cite journal |last1=Laheri |first1=Saniya |last2=Ashary |first2=Nancy |last3=Bhatt |first3=Purvi |last4=Modi |first4=Deepak |title=Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion |journal=Journal of Assisted Reproduction and Genetics |doi=10.1007/s10815-018-1231-4 |pmid=29968069 }}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Verhage HG, Fazleabas AT, Donnelly K |title=The in vitro synthesis and release of proteins by the human oviduct |journal=Endocrinology |volume=122 |issue= 4 |pages= 1639–45 |year= 1988 |pmid= 3278893 |doi=10.1210/endo-122-4-1639 }}
| citations =
*{{cite journal  |vauthors=Iontcheva I, Oppenheim FG, Troxler RF |title=Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins |journal=J. Dent. Res. |volume=76 |issue= 3 |pages= 734–43 |year= 1997 |pmid= 9109822 |doi=10.1177/00220345970760030501 }}
*{{cite journal  | author=Verhage HG, Fazleabas AT, Donnelly K |title=The in vitro synthesis and release of proteins by the human oviduct. |journal=Endocrinology |volume=122 |issue= 4 |pages= 1639-45 |year= 1988 |pmid= 3278893 |doi= }}
*{{cite journal  |vauthors=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732–9 |year= 2000 |pmid= 10728974 |doi=10.1177/00220345000790020601 }}
*{{cite journal  | author=Arias EB, Verhage HG, Jaffe RC |title=Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. |journal=Biol. Reprod. |volume=51 |issue= 4 |pages= 685-94 |year= 1995 |pmid= 7819450 |doi= }}
*{{cite journal  |vauthors=Agarwal A, Yeung WS, Lee KF |title=Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter |journal=Mol. Hum. Reprod. |volume=8 |issue= 2 |pages= 167–75 |year= 2002 |pmid= 11818519 |doi=10.1093/molehr/8.2.167 }}
*{{cite journal  | author=Iontcheva I, Oppenheim FG, Troxler RF |title=Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins. |journal=J. Dent. Res. |volume=76 |issue= 3 |pages= 734-43 |year= 1997 |pmid= 9109822 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Lapensée L, Paquette Y, Bleau G |title=Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). |journal=Fertil. Steril. |volume=68 |issue= 4 |pages= 702-8 |year= 1997 |pmid= 9341614 |doi= }}
*{{cite journal  |vauthors=Lok IH, Briton-Jones CM, Yuen PM, Haines CJ |title=Variable expression of oviductin mRNA at different stages of human reproductive cycle |journal=J. Assist. Reprod. Genet. |volume=19 |issue= 12 |pages= 569–76 |year= 2003 |pmid= 12503889 |doi=10.1023/A:1021263132176 |pmc=3455833}}
*{{cite journal  | author=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732-9 |year= 2000 |pmid= 10728974 |doi=  }}
*{{cite journal  |vauthors=Chen Q, Zhang J, Sweet F |title=Homology of primate DNA fragments for estrous-associated oviductal glycoprotein |journal=Hereditas |volume=139 |issue= 1 |pages= 75–9 |year= 2004 |pmid= 14641477 |doi=10.1111/j.1601-5223.2003.01640.x }}
*{{cite journal  | author=Agarwal A, Yeung WS, Lee KF |title=Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. |journal=Mol. Hum. Reprod. |volume=8 |issue= 2 |pages= 167-75 |year= 2002 |pmid= 11818519 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Woo MM |title=Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer |journal=Clin. Cancer Res. |volume=10 |issue= 23 |pages= 7958–64 |year= 2005 |pmid= 15585630 |doi= 10.1158/1078-0432.CCR-04-1261 |name-list-format=vanc| author2=Alkushi A  | author3=Verhage HG  | display-authors=3  | last4=Magliocco  | first4=AM  | last5=Leung  | first5=PC  | last6=Gilks  | first6=CB  | last7=Auersperg  | first7=N }}
*{{cite journal  | author=Lok IH, Briton-Jones CM, Yuen PM, Haines CJ |title=Variable expression of oviductin mRNA at different stages of human reproductive cycle. |journal=J. Assist. Reprod. Genet. |volume=19 |issue= 12 |pages= 569-76 |year= 2003 |pmid= 12503889 |doi= }}
*{{cite journal  | author=Ling L |title=Expression of human oviductin in an immortalized human oviductal cell line |journal=Fertil. Steril. |volume=84 Suppl 2 |issue=  |pages= 1095–103 |year= 2006 |pmid= 16209999 |doi= 10.1016/j.fertnstert.2005.06.006 |name-list-format=vanc| author2=Lee YL  | author3=Lee KF  | display-authors=3  | last4=Tsao  | first4=Sai-Wah  | last5=Yeung  | first5=William S.B.  | last6=Kan  | first6=Frederick W.K. }}
*{{cite journal  | author=Chen Q, Zhang J, Sweet F |title=Homology of primate DNA fragments for estrous-associated oviductal glycoprotein. |journal=Hereditas |volume=139 |issue= 1 |pages= 75-9 |year= 2004 |pmid= 14641477 |doi=  }}
*{{cite journal  |vauthors=Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U |title=Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9 |journal=Mol. Hum. Reprod. |volume=12 |issue= 4 |pages= 275–82 |year= 2006 |pmid= 16567366 |doi= 10.1093/molehr/gal028 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Woo MM, Alkushi A, Verhage HG, ''et al.'' |title=Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 23 |pages= 7958-64 |year= 2005 |pmid= 15585630 |doi= 10.1158/1078-0432.CCR-04-1261 }}
*{{cite journal  | author=Ling L, Lee YL, Lee KF, ''et al.'' |title=Expression of human oviductin in an immortalized human oviductal cell line. |journal=Fertil. Steril. |volume=84 Suppl 2 |issue=  |pages= 1095-103 |year= 2006 |pmid= 16209999 |doi= 10.1016/j.fertnstert.2005.06.006 }}
*{{cite journal  | author=Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U |title=Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. |journal=Mol. Hum. Reprod. |volume=12 |issue= 4 |pages= 275-82 |year= 2006 |pmid= 16567366 |doi= 10.1093/molehr/gal028 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 21:50, 11 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.[1][2][3]

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[3] Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [4] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure [5]

References

  1. ↑ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.
  2. ↑ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
  3. ↑ 3.0 3.1 "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
  4. ↑ Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. PMID 28229966. Retrieved 16 July 2018.
  5. ↑ Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak. "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. doi:10.1007/s10815-018-1231-4. PMID 29968069.
  • Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak. "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. doi:10.1007/s10815-018-1231-4. PMID 29968069.

Further reading


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