PARP3: Difference between revisions

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Latest revision as of 15:05, 14 February 2018

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.^[1]^[2]

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

References

↑ Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.
↑ ^2.0 ^2.1 "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

Bashford CL, Chance B, Lloyd D, Poole RK (1981). "Oscillations of redox states in synchronously dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe". Biophys. J. 29 (1): 1–11. Bibcode:1980BpJ....29....1B. doi:10.1016/S0006-3495(80)85114-9. PMC 1328658. PMID 7260241.
Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
Berghammer H, Ebner M, Marksteiner R, Auer B (1999). "pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans". FEBS Lett. 449 (2–3): 259–63. doi:10.1016/S0014-5793(99)00448-2. PMID 10338144.
Still IH, Vince P, Cowell JK (2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Glowacki G, Braren R, Cetkovic-Cvrlje M, et al. (2001). "Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5". Gene. 275 (2): 267–77. doi:10.1016/S0378-1119(01)00608-4. PMID 11587854.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Augustin A, Spenlehauer C, Dumond H, et al. (2004). "PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression". J. Cell Sci. 116 (Pt 8): 1551–62. doi:10.1242/jcs.00341. PMID 12640039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Rouleau M, McDonald D, Gagné P, et al. (2007). "PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery". J. Cell. Biochem. 100 (2): 385–401. doi:10.1002/jcb.21051. PMID 16924674.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Lehtiö L, Jemth AS, Collins R, et al. (2009). "Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3". J. Med. Chem. 52 (9): 3108–3111. doi:10.1021/jm900052j. PMID 19354255.

External links

PARP3 human gene location in the UCSC Genome Browser.
PARP3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid10329013-1] Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.

[entrez-2] 2.0 ^2.1 "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

[1]

[2]

@@ Line 1: / Line 1: @@
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{Infobox_gene}}
-{{GNF_Protein_box
+'''Poly [ADP-ribose] polymerase 3''' is an [[enzyme]] that in humans is encoded by the ''PARP3'' [[gene]].<ref name="pmid10329013">{{cite journal | author = Johansson M | title = A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues | journal = Genomics | volume = 57 | issue = 3 | pages = 442–5 |date=Aug 1999 | pmid = 10329013 | pmc =  | doi = 10.1006/geno.1999.5799 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10039| accessdate = }}</ref>
- | image = PBB_Protein_PARP3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2pa9.
- | PDB = {{PDB2|2pa9}}
- | Name = Poly (ADP-ribose) polymerase family, member 3
- | HGNCid = 273
- | Symbol = PARP3
- | AltSymbols =; ADPRTL2; ADPRTL3; ADPRT3; IRT1; hPARP-3; pADPRT-3
- | OMIM = 607726
- | ECnumber =
- | Homologene = 4005
- | MGIid = 1891258
- | GeneAtlas_image1 = PBB_GE_PARP3_209940_at_tn.png
- | Function = {{GNF_GO|id=GO:0003950 |text = NAD+ ADP-ribosyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10039
-    | Hs_Ensembl = ENSG00000041880
-    | Hs_RefseqProtein = NP_001003931
-    | Hs_RefseqmRNA = NM_001003931
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 51951401
-    | Hs_GenLoc_end = 51957921
-    | Hs_Uniprot = Q9Y6F1
-    | Mm_EntrezGene = 235587
-    | Mm_Ensembl = ENSMUSG00000023249
-    | Mm_RefseqmRNA = NM_145619
-    | Mm_RefseqProtein = NP_663594
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 106328454
-    | Mm_GenLoc_end = 106334752
-    | Mm_Uniprot =
-  }}
-}}
-'''Poly (ADP-ribose) polymerase family, member 3''', also known as '''PARP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10039| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10039| accessdate = }}</ref>
+| summary_text = The [[protein]] encoded by this gene belongs to the PARP family. These enzymes modify [[nuclear proteins]] by [[poly-ADP-ribosylation]], which is required for [[DNA repair]], regulation of [[apoptosis]], and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter [[centriole]] throughout the [[cell cycle]]. Alternatively spliced transcript variants encoding different [[isoforms]] have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10039| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bashford CL, Chance B, Lloyd D, Poole RK |title=Oscillations of redox states in synchronously dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe. |journal=Biophys. J. |volume=29 |issue= 1 |pages= 1-11 |year= 1981 |pmid= 7260241 |doi=  }}
+*{{cite journal  | vauthors=Bashford CL, Chance B, Lloyd D, Poole RK |title=Oscillations of redox states in synchronously dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe. |journal=Biophys. J. |volume=29 |issue= 1 |pages= 1–11 |year= 1981 |pmid= 7260241 |doi=10.1016/S0006-3495(80)85114-9  | pmc=1328658 |bibcode=1980BpJ....29....1B}}
-*{{cite journal  | author=Borggrefe T, Wabl M, Akhmedov AT, Jessberger R |title=A B-cell-specific DNA recombination complex. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17025-35 |year= 1998 |pmid= 9642267 |doi=  }}
+*{{cite journal  | vauthors=Borggrefe T, Wabl M, Akhmedov AT, Jessberger R |title=A B-cell-specific DNA recombination complex. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17025–35 |year= 1998 |pmid= 9642267 |doi=10.1074/jbc.273.27.17025  }}
-*{{cite journal  | author=Johansson M |title=A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. |journal=Genomics |volume=57 |issue= 3 |pages= 442-5 |year= 1999 |pmid= 10329013 |doi= 10.1006/geno.1999.5799 }}
+*{{cite journal  | vauthors=Berghammer H, Ebner M, Marksteiner R, Auer B |title=pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. |journal=FEBS Lett. |volume=449 |issue= 2–3 |pages= 259–63 |year= 1999 |pmid= 10338144 |doi=10.1016/S0014-5793(99)00448-2  }}
-*{{cite journal  | author=Berghammer H, Ebner M, Marksteiner R, Auer B |title=pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. |journal=FEBS Lett. |volume=449 |issue= 2-3 |pages= 259-63 |year= 1999 |pmid= 10338144 |doi=  }}
+*{{cite journal  | vauthors=Still IH, Vince P, Cowell JK |title=Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein. |journal=Genomics |volume=62 |issue= 3 |pages= 533–6 |year= 2000 |pmid= 10644454 |doi= 10.1006/geno.1999.6024 }}
-*{{cite journal  | author=Still IH, Vince P, Cowell JK |title=Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein. |journal=Genomics |volume=62 |issue= 3 |pages= 533-6 |year= 2000 |pmid= 10644454 |doi= 10.1006/geno.1999.6024 }}
+*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |bibcode = 2000PNAS...97.3491D }}
-*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
+*{{cite journal   |vauthors=Glowacki G, Braren R, Cetkovic-Cvrlje M, etal |title=Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. |journal=Gene |volume=275 |issue= 2 |pages= 267–77 |year= 2001 |pmid= 11587854 |doi=10.1016/S0378-1119(01)00608-4  }}
-*{{cite journal  | author=Glowacki G, Braren R, Cetkovic-Cvrlje M, ''et al.'' |title=Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. |journal=Gene |volume=275 |issue= 2 |pages= 267-77 |year= 2001 |pmid= 11587854 |doi=  }}
+*{{cite journal   |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=  }}
-*{{cite journal  | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205-20 |year= 2002 |pmid= 12107410 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode = 2002PNAS...9916899M }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Augustin A, Spenlehauer C, Dumond H, etal |title=PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. |journal=J. Cell Sci. |volume=116 |issue= Pt 8 |pages= 1551–62 |year= 2004 |pmid= 12640039 |doi=10.1242/jcs.00341  }}
-*{{cite journal  | author=Augustin A, Spenlehauer C, Dumond H, ''et al.'' |title=PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. |journal=J. Cell. Sci. |volume=116 |issue= Pt 8 |pages= 1551-62 |year= 2004 |pmid= 12640039 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode = 2005Natur.437.1173R }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Rouleau M, McDonald D, Gagné P, etal |title=PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. |journal=J. Cell. Biochem. |volume=100 |issue= 2 |pages= 385–401 |year= 2007 |pmid= 16924674 |doi= 10.1002/jcb.21051 }}
-*{{cite journal  | author=Rouleau M, McDonald D, Gagné P, ''et al.'' |title=PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. |journal=J. Cell. Biochem. |volume=100 |issue= 2 |pages= 385-401 |year= 2007 |pmid= 16924674 |doi= 10.1002/jcb.21051 }}
+*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
+*{{cite journal   |vauthors=Lehtiö L, Jemth AS, Collins R, etal |title=Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. |journal=J. Med. Chem. |volume=52 |issue=  9|pages= 3108–3111 |year= 2009 |pmid= 19354255 |doi=10.1021/jm900052j}}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* {{UCSC genome browser|PARP3}}
+* {{UCSC gene details|PARP3}}
+{{PDB Gallery|geneid=10039}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-3-stub}}

PARP3: Difference between revisions

Latest revision as of 15:05, 14 February 2018

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