PCGF2: Difference between revisions

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Latest revision as of 17:44, 7 September 2017

Polycomb group RING finger protein 2 is a protein that in humans is encoded by the PCGF2 gene.^[1]^[2]

Function

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.^[2]

References

↑ Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509.
↑ ^2.0 ^2.1 "Entrez Gene: PCGF2 polycomb group ring finger 2".

Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T (August 2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity. 15 (2): 275–87. doi:10.1016/S1074-7613(01)00182-0. PMID 11520462.
Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M (February 2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunology Letters. 80 (2): 139–43. doi:10.1016/S0165-2478(01)00315-7. PMID 11750047.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H (September 2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. PMID 12183370.
Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer. 9 (1): 33–8. doi:10.1007/BF02967544. PMID 12196719.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F (December 2006). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clinical Cancer Research. 12 (23): 6929–36. doi:10.1158/1078-0432.CCR-06-0788. PMID 17145810.
Guo WJ, Datta S, Band V, Dimri GP (February 2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins". Molecular Biology of the Cell. 18 (2): 536–46. doi:10.1091/mbc.E06-05-0447. PMC 1783768. PMID 17151361.
Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD (July 2007). "Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis". Molecular and Cellular Biology. 27 (13): 4968–79. doi:10.1128/MCB.02244-06. PMC 1951487. PMID 17452456.
Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP (June 2007). "Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells". Cancer Research. 67 (11): 5083–9. doi:10.1158/0008-5472.CAN-06-4368. PMC 2386662. PMID 17545584.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid8325509-1] Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509.

[entrez-2] 2.0 ^2.1 "Entrez Gene: PCGF2 polycomb group ring finger 2".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Polycomb group RING finger protein 2''' is a [[protein]] that in humans is encoded by the ''PCGF2'' [[gene]].<ref name="pmid8325509">{{cite journal | vauthors = Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M | title = Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif | journal = Gene | volume = 129 | issue = 2 | pages = 249–55 | date = July 1993 | pmid = 8325509 | pmc =  | doi = 10.1016/0378-1119(93)90275-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCGF2 polycomb group ring finger 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7703| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_PCGF2_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h0d.
- | PDB = {{PDB2|2h0d}}
- | Name = Polycomb group ring finger 2
- | HGNCid = 12929
- | Symbol = PCGF2
- | AltSymbols =; MEL-18; MGC10545; RNF110; ZNF144
- | OMIM = 600346
- | ECnumber =
- | Homologene = 5174
- | MGIid = 99161
- | GeneAtlas_image1 = PBB_GE_PCGF2_213551_x_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PCGF2_203792_x_at_tn.png
- | GeneAtlas_image3 = PBB_GE_PCGF2_203793_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0001739 |text = sex chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016604 |text = nuclear body}} {{GNF_GO|id=GO:0031519 |text = PcG protein complex}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0016573 |text = histone acetylation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7703
-    | Hs_Ensembl = ENSG00000056661
-    | Hs_RefseqProtein = NP_009075
-    | Hs_RefseqmRNA = NM_007144
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 17
-    | Hs_GenLoc_start = 34144854
-    | Hs_GenLoc_end = 34159596
-    | Hs_Uniprot = P35227
-    | Mm_EntrezGene = 22658
-    | Mm_Ensembl = ENSMUSG00000018537
-    | Mm_RefseqmRNA = NM_009545
-    | Mm_RefseqProtein = NP_033571
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 97505910
-    | Mm_GenLoc_end = 97516587
-    | Mm_Uniprot = P23798
-  }}
-}}
-'''Polycomb group ring finger 2''', also known as '''PCGF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCGF2 polycomb group ring finger 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7703| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene contains a [[RING finger domain|RING finger]] motif and is similar to the [[polycomb group]] (PcG) gene products. PcG gene products form complexes via [[protein-protein interaction]] and maintain the [[repressor|transcription repression]] of genes involved in [[embryogenesis]], cell cycles, and [[tumorigenesis]]. This protein was shown to act as a negative regulator of transcription and has [[tumor suppressor]] activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different [[cytokine]]s, [[chemokine]]s, and [[chemokine receptor]]s, and thus plays an important role in [[lymphocyte]] differentiation and migration, as well as in immune responses.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.<ref name="entrez">{{cite web | title = Entrez Gene: PCGF2 polycomb group ring finger 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7703| accessdate = }}</ref>
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
-| citations =
+* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
-*{{cite journal  | author=Ishida A, Asano H, Hasegawa M, ''et al.'' |title=Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. |journal=Gene |volume=129 |issue= 2 |pages= 249-55 |year= 1993 |pmid= 8325509 |doi=  }}
+* {{cite journal | vauthors = Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T | title = Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene | journal = Immunity | volume = 15 | issue = 2 | pages = 275–87 | date = August 2001 | pmid = 11520462 | doi = 10.1016/S1074-7613(01)00182-0 }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+* {{cite journal | vauthors = Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M | title = Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18 | journal = Immunology Letters | volume = 80 | issue = 2 | pages = 139–43 | date = February 2002 | pmid = 11750047 | doi = 10.1016/S0165-2478(01)00315-7 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+* {{cite journal | vauthors = Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE | title = The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans | journal = Molecular and Cellular Biology | volume = 22 | issue = 17 | pages = 6070–8 | date = September 2002 | pmid = 12167701 | pmc = 134016 | doi = 10.1128/MCB.22.17.6070-6078.2002 }}
-*{{cite journal  | author=Kimura M, Koseki Y, Yamashita M, ''et al.'' |title=Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. |journal=Immunity |volume=15 |issue= 2 |pages= 275-87 |year= 2001 |pmid= 11520462 |doi=  }}
+* {{cite journal | vauthors = Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H | title = Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice | journal = Development | volume = 129 | issue = 18 | pages = 4171–83 | date = September 2002 | pmid = 12183370 | doi =  }}
-*{{cite journal  | author=Miyazaki K, Inoue H, Onai N, ''et al.'' |title=Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18. |journal=Immunol. Lett. |volume=80 |issue= 2 |pages= 139-43 |year= 2002 |pmid= 11750047 |doi=  }}
+* {{cite journal | vauthors = Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y | title = Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines | journal = Breast Cancer | volume = 9 | issue = 1 | pages = 33–8 | year = 2002 | pmid = 12196719 | doi = 10.1007/BF02967544 }}
-*{{cite journal  | author=Levine SS, Weiss A, Erdjument-Bromage H, ''et al.'' |title=The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6070-8 |year= 2002 |pmid= 12167701 |doi=  }}
+* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
-*{{cite journal  | author=Suzuki M, Mizutani-Koseki Y, Fujimura Y, ''et al.'' |title=Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. |journal=Development |volume=129 |issue= 18 |pages= 4171-83 |year= 2002 |pmid= 12183370 |doi=  }}
+* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
-*{{cite journal  | author=Matsuo F, Yano K, Saito H, ''et al.'' |title=Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines. |journal=Breast Cancer |volume=9 |issue= 1 |pages= 33-8 |year= 2002 |pmid= 12196719 |doi=  }}
+* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F | title = Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas | journal = Clinical Cancer Research | volume = 12 | issue = 23 | pages = 6929–36 | date = December 2006 | pmid = 17145810 | doi = 10.1158/1078-0432.CCR-06-0788 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal | vauthors = Guo WJ, Datta S, Band V, Dimri GP | title = Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins | journal = Molecular Biology of the Cell | volume = 18 | issue = 2 | pages = 536–46 | date = February 2007 | pmid = 17151361 | pmc = 1783768 | doi = 10.1091/mbc.E06-05-0447 }}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
+* {{cite journal | vauthors = Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD | title = Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis | journal = Molecular and Cellular Biology | volume = 27 | issue = 13 | pages = 4968–79 | date = July 2007 | pmid = 17452456 | pmc = 1951487 | doi = 10.1128/MCB.02244-06 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+* {{cite journal | vauthors = Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP | title = Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells | journal = Cancer Research | volume = 67 | issue = 11 | pages = 5083–9 | date = June 2007 | pmid = 17545584 | pmc = 2386662 | doi = 10.1158/0008-5472.CAN-06-4368 }}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
+* {{cite journal | vauthors = Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M | title = Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns | journal = Genome Biology | volume = 8 | issue = 8 | pages = R154 | year = 2007 | pmid = 17672918 | pmc = 2374985 | doi = 10.1186/gb-2007-8-8-r154 }}
-*{{cite journal  | author=Silva J, García JM, Peña C, ''et al.'' |title=Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6929-36 |year= 2007 |pmid= 17145810 |doi= 10.1158/1078-0432.CCR-06-0788 }}
-*{{cite journal  | author=Guo WJ, Datta S, Band V, Dimri GP |title=Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. |journal=Mol. Biol. Cell |volume=18 |issue= 2 |pages= 536-46 |year= 2007 |pmid= 17151361 |doi= 10.1091/mbc.E06-05-0447 }}
-*{{cite journal  | author=Wiederschain D, Chen L, Johnson B, ''et al.'' |title=Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. |journal=Mol. Cell. Biol. |volume=27 |issue= 13 |pages= 4968-79 |year= 2007 |pmid= 17452456 |doi= 10.1128/MCB.02244-06 }}
-*{{cite journal  | author=Guo WJ, Zeng MS, Yadav A, ''et al.'' |title=Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. |journal=Cancer Res. |volume=67 |issue= 11 |pages= 5083-9 |year= 2007 |pmid= 17545584 |doi= 10.1158/0008-5472.CAN-06-4368 }}
-*{{cite journal  | author=Szafranski K, Schindler S, Taudien S, ''et al.'' |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= |volume=8 |issue= 8 |pages= R154 |year=  |pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154 }}
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 {{refend}}
+{{PDB Gallery|geneid=7703}}
-{{protein-stub}}
+{{gene-17-stub}}
-{{WikiDoc Sources}}

PCGF2: Difference between revisions

Latest revision as of 17:44, 7 September 2017

Function

References

Further reading

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