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{{Infobox_gene}}
'''Phosphoenolpyruvate carboxykinase 1 (soluble)''', also known as '''PCK1''', is an [[enzyme]] which in humans is encoded by the ''PCK1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5105| accessdate = }}</ref><ref name="pmid1492743">{{cite journal | vauthors = Pilz AJ, Willer E, Povey S, Abbott CM | title = The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2 | journal = Ann. Hum. Genet. | volume = 56 | issue = Pt 4 | pages = 289–93 |date=October 1992 | pmid = 1492743 | doi = 10.1111/j.1469-1809.1992.tb01155.x| url =  }}</ref>
== Function==
This enzyme is a main control point for the regulation of [[gluconeogenesis]]. The cytosolic enzyme encoded by this gene, along with [[guanosine triphosphate|GTP]], catalyzes the formation of [[phosphoenolpyruvate]] from [[oxaloacetate]], with the release of [[carbon dioxide]] and [[guanosine diphosphate|GDP]]. The expression of this gene can be regulated by [[insulin]], [[glucocorticoids]], [[glucagon]], [[cyclic AMP|cAMP]], and diet. A mitochondrial isozyme of the encoded protein also has been characterized.<ref name="entrez"/>
==Interactive pathway map==
{{GlycolysisGluconeogenesis_WP534|highlight=PCK1}}
==See also==
*[[PEPCK]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Beale EG, Hammer RE, Antoine B, Forest C |title=Disregulated [[glyceroneogenesis]]: PCK1 as a candidate diabetes and obesity gene. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 3 |pages= 129–35 |year= 2004 |pmid= 15046742 |doi= 10.1016/j.tem.2004.02.006 }}
*{{cite journal  | vauthors=Pilz AJ, Willer E, Povey S, Abbott CM |title=The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2. |journal=Ann. Hum. Genet. |volume=56 |issue= Pt 4 |pages= 289–93 |year= 1993 |pmid= 1492743 |doi=10.1111/j.1469-1809.1992.tb01155.x  }}
*{{cite journal  |vauthors=Giralt M, Park EA, Gurney AL, etal |title=Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements. |journal=J. Biol. Chem. |volume=266 |issue= 32 |pages= 21991–6 |year= 1991 |pmid= 1657985 |doi=  }}
*{{cite journal  |vauthors=Beale EG, Chrapkiewicz NB, Scoble HA, etal |title=Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. |journal=J. Biol. Chem. |volume=260 |issue= 19 |pages= 10748–60 |year= 1985 |pmid= 2993287 |doi=  }}
*{{cite journal  |vauthors=Ting CN, Burgess DL, Chamberlain JS, etal |title=Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20. |journal=Genomics |volume=16 |issue= 3 |pages= 698–706 |year= 1993 |pmid= 8325643 |doi= 10.1006/geno.1993.1250 }}
*{{cite journal  |vauthors=Yu H, Thun R, Chandrasekharappa S, etal |title=Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2. |journal=Genomics |volume=15 |issue= 1 |pages= 219–21 |year= 1993 |pmid= 8432541 |doi= 10.1006/geno.1993.1040 }}
*{{cite journal  |vauthors=Stoffel M, Xiang KS, Espinosa R, etal |title=cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 1–4 |year= 1993 |pmid= 8490617 |doi=10.1093/hmg/2.1.1  }}
*{{cite journal  |vauthors=O'Brien RM, Printz RL, Halmi N, etal |title=Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter. |journal=Biochim. Biophys. Acta |volume=1264 |issue= 3 |pages= 284–8 |year= 1996 |pmid= 8547315 |doi=  10.1016/0167-4781(95)00194-8}}
*{{cite journal  |vauthors=Parissi V, Calmels C, De Soultrait VR, etal |title=Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60. |journal=J. Virol. |volume=75 |issue= 23 |pages= 11344–53 |year= 2001 |pmid= 11689615 |doi= 10.1128/JVI.75.23.11344-11353.2001  | pmc=114720 }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  |vauthors=Dunten P, Belunis C, Crowther R, etal |title=Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. |journal=J. Mol. Biol. |volume=316 |issue= 2 |pages= 257–64 |year= 2002 |pmid= 11851336 |doi= 10.1006/jmbi.2001.5364 }}
*{{cite journal  | vauthors=Jurado LA, Song S, Roesler WJ, Park EA |title=Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27606–12 |year= 2002 |pmid= 11997389 |doi= 10.1074/jbc.M201429200 }}
*{{cite journal  | vauthors=Wilson HL, McFie PJ, Roesler WJ |title=Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43895–902 |year= 2003 |pmid= 12237288 |doi= 10.1074/jbc.M203169200 }}
*{{cite journal  | vauthors=Borgius LJ, Steffensen KR, Gustafsson JA, Treuter E |title=Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49761–6 |year= 2003 |pmid= 12324453 |doi= 10.1074/jbc.M205641200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Chakravarty K, Wu SY, Chiang CM, etal |title=SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15385–95 |year= 2004 |pmid= 14744869 |doi= 10.1074/jbc.M309905200 }}
*{{cite journal  |vauthors=Cao H, van der Veer E, Ban MR, etal |title=Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 898–903 |year= 2004 |pmid= 14764811 |doi=10.1210/jc.2003-031361  }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | vauthors=Hajarnis S, Schroeder JM, Curthoys NP |title=3'-Untranslated region of phosphoenolpyruvate carboxykinase mRNA contains multiple instability elements that bind AUF1. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28272–80 |year= 2005 |pmid= 15951444 |doi= 10.1074/jbc.M501204200 }}
}}
{{refend}}
{{PDB Gallery|geneid=5105}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PCK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1khb.
| PDB = {{PDB2|1khb}}, {{PDB2|1khe}}, {{PDB2|1khf}}, {{PDB2|1khg}}, {{PDB2|1m51}}, {{PDB2|1nhx}}, {{PDB2|2gmv}}
| Name = Phosphoenolpyruvate carboxykinase 1 (soluble)
| HGNCid = 8724
| Symbol = PCK1
| AltSymbols =; MGC22652; PEPCK1; PEPCKC
| OMIM = 261680
| ECnumber = 
| Homologene = 1944
| MGIid = 97501
| GeneAtlas_image1 = PBB_GE_PCK1_208383_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004613 |text = phosphoenolpyruvate carboxykinase (GTP) activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006094 |text = gluconeogenesis}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0046327 |text = glycerol biosynthetic process from pyruvate}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5105
    | Hs_Ensembl = ENSG00000124253
    | Hs_RefseqProtein = NP_002582
    | Hs_RefseqmRNA = NM_002591
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 55569543
    | Hs_GenLoc_end = 55574922
    | Hs_Uniprot = P35558
    | Mm_EntrezGene = 18534
    | Mm_Ensembl = ENSMUSG00000027513
    | Mm_RefseqmRNA = NM_011044
    | Mm_RefseqProtein = NP_035174
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 172796012
    | Mm_GenLoc_end = 172802209
    | Mm_Uniprot = Q8BSX3
  }}
}}
'''Phosphoenolpyruvate carboxykinase 1 (soluble)''', also known as '''PCK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5105| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5105| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Beale EG, Hammer RE, Antoine B, Forest C |title=Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 3 |pages= 129-35 |year= 2004 |pmid= 15046742 |doi= 10.1016/j.tem.2004.02.006 }}
*{{cite journal  | author=Pilz AJ, Willer E, Povey S, Abbott CM |title=The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2. |journal=Ann. Hum. Genet. |volume=56 |issue= Pt 4 |pages= 289-93 |year= 1993 |pmid= 1492743 |doi=  }}
*{{cite journal  | author=Giralt M, Park EA, Gurney AL, ''et al.'' |title=Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements. |journal=J. Biol. Chem. |volume=266 |issue= 32 |pages= 21991-6 |year= 1991 |pmid= 1657985 |doi=  }}
*{{cite journal  | author=Beale EG, Chrapkiewicz NB, Scoble HA, ''et al.'' |title=Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. |journal=J. Biol. Chem. |volume=260 |issue= 19 |pages= 10748-60 |year= 1985 |pmid= 2993287 |doi=  }}
*{{cite journal  | author=Ting CN, Burgess DL, Chamberlain JS, ''et al.'' |title=Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20. |journal=Genomics |volume=16 |issue= 3 |pages= 698-706 |year= 1993 |pmid= 8325643 |doi= 10.1006/geno.1993.1250 }}
*{{cite journal  | author=Yu H, Thun R, Chandrasekharappa S, ''et al.'' |title=Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2. |journal=Genomics |volume=15 |issue= 1 |pages= 219-21 |year= 1993 |pmid= 8432541 |doi= 10.1006/geno.1993.1040 }}
*{{cite journal  | author=Stoffel M, Xiang KS, Espinosa R, ''et al.'' |title=cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 1-4 |year= 1993 |pmid= 8490617 |doi=  }}
*{{cite journal  | author=O'Brien RM, Printz RL, Halmi N, ''et al.'' |title=Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter. |journal=Biochim. Biophys. Acta |volume=1264 |issue= 3 |pages= 284-8 |year= 1996 |pmid= 8547315 |doi=  }}
*{{cite journal  | author=Parissi V, Calmels C, De Soultrait VR, ''et al.'' |title=Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60. |journal=J. Virol. |volume=75 |issue= 23 |pages= 11344-53 |year= 2001 |pmid= 11689615 |doi= 10.1128/JVI.75.23.11344-11353.2001 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Dunten P, Belunis C, Crowther R, ''et al.'' |title=Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. |journal=J. Mol. Biol. |volume=316 |issue= 2 |pages= 257-64 |year= 2002 |pmid= 11851336 |doi= 10.1006/jmbi.2001.5364 }}
*{{cite journal  | author=Jurado LA, Song S, Roesler WJ, Park EA |title=Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27606-12 |year= 2002 |pmid= 11997389 |doi= 10.1074/jbc.M201429200 }}
*{{cite journal  | author=Wilson HL, McFie PJ, Roesler WJ |title=Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43895-902 |year= 2003 |pmid= 12237288 |doi= 10.1074/jbc.M203169200 }}
*{{cite journal  | author=Borgius LJ, Steffensen KR, Gustafsson JA, Treuter E |title=Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49761-6 |year= 2003 |pmid= 12324453 |doi= 10.1074/jbc.M205641200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Chakravarty K, Wu SY, Chiang CM, ''et al.'' |title=SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15385-95 |year= 2004 |pmid= 14744869 |doi= 10.1074/jbc.M309905200 }}
*{{cite journal  | author=Cao H, van der Veer E, Ban MR, ''et al.'' |title=Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 898-903 |year= 2004 |pmid= 14764811 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hajarnis S, Schroeder JM, Curthoys NP |title=3'-Untranslated region of phosphoenolpyruvate carboxykinase mRNA contains multiple instability elements that bind AUF1. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28272-80 |year= 2005 |pmid= 15951444 |doi= 10.1074/jbc.M501204200 }}
}}
{{refend}}


{{protein-stub}}
{{gene-20-stub}}
{{WikiDoc Sources}}

Latest revision as of 17:45, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.[1][2]

Function

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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<imagemap> Image:WP534.png
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".
  2. ↑ Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743.

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PCK1&oldid=1419486"