PDCD6IP: Difference between revisions

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{{Infobox_gene}}
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'''Programmed cell death 6-interacting protein''' is a [[protein]] that in humans is encoded by the ''PDCD6IP'' [[gene]].<ref name="pmid9880530">{{cite journal |vauthors=Vito P, Pellegrini L, Guiet C, D'Adamio L | title = Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction | journal = J Biol Chem | volume = 274 | issue = 3 | pages = 1533–40 |date=Feb 1999 | pmid = 9880530 | pmc =  | doi =10.1074/jbc.274.3.1533 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDCD6IP programmed cell death 6 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDCD6IP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oev.
| PDB = {{PDB2|2oev}}, {{PDB2|2oew}}, {{PDB2|2oex}}, {{PDB2|2ojq}}
| Name = Programmed cell death 6 interacting protein
| HGNCid = 8766
| Symbol = PDCD6IP
| AltSymbols =; AIP1; Alix; DRIP4; HP95; MGC17003
| OMIM = 608074
| ECnumber = 
| Homologene = 22614
| MGIid = 1333753
| GeneAtlas_image1 = PBB_GE_PDCD6IP_217746_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10015
    | Hs_Ensembl = ENSG00000170248
    | Hs_RefseqProtein = NP_037506
    | Hs_RefseqmRNA = NM_013374
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 33814561
    | Hs_GenLoc_end = 33886198
    | Hs_Uniprot = Q8WUM4
    | Mm_EntrezGene = 18571
    | Mm_Ensembl = ENSMUSG00000032504
    | Mm_RefseqmRNA = NM_011052
    | Mm_RefseqProtein = NP_035182
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 113501953
    | Mm_GenLoc_end = 113556927
    | Mm_Uniprot = Q3TED2
  }}
}}
'''Programmed cell death 6 interacting protein''', also known as '''PDCD6IP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDCD6IP programmed cell death 6 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner.  This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.<ref name="entrez">{{cite web | title = Entrez Gene: PDCD6IP programmed cell death 6 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015| accessdate = }}</ref>
| summary_text = This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner.  This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.<ref name="entrez" />
}}
}}
==Interactions==
PDCD6IP has been shown to [[Protein-protein interaction|interact]] with [[PDCD6]].<ref name=pmid9880530 /><ref name=pmid11883939>{{cite journal |last=Satoh |first=Hirokazu |authorlink= |author2=Shibata Hideki |author3=Nakano Yoshimi |author4=Kitaura Yasuyuki |author5=Maki Masatoshi  |date=Mar 2002 |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue=5 |pages=1166–72 |publisher= |location = United States| issn = 0006-291X| pmid = 11883939 |doi = 10.1006/bbrc.2002.6600 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Wood JD, Yuan J, Margolis RL, ''et al.'' |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149-60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
*{{cite journal   |vauthors=Wood JD, Yuan J, Margolis RL, etal |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
*{{cite journal  | author=Vito P, Pellegrini L, Guiet C, D'Adamio L |title=Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1533-40 |year= 1999 |pmid= 9880530 |doi= }}
*{{cite journal  |vauthors=Missotten M, Nichols A, Rieger K, Sadoul R |title=Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein |journal=Cell Death Differ. |volume=6 |issue= 2 |pages= 124–9 |year= 1999 |pmid= 10200558 |doi= 10.1038/sj.cdd.4400456 }}
*{{cite journal | author=Missotten M, Nichols A, Rieger K, Sadoul R |title=Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. |journal=Cell Death Differ. |volume=6 |issue= 2 |pages= 124-9 |year= 1999 |pmid= 10200558 |doi= 10.1038/sj.cdd.4400456 }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65  }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal   |vauthors=Wu Y, Pan S, Che S, etal |title=Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells |journal=Differentiation |volume=67 |issue= 4–5 |pages= 139–53 |year= 2002 |pmid= 11683497 |doi=10.1046/j.1432-0436.2001.670406.x }}
*{{cite journal | author=Wu Y, Pan S, Che S, ''et al.'' |title=Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells. |journal=Differentiation |volume=67 |issue= 4-5 |pages= 139-53 |year= 2002 |pmid= 11683497 |doi= }}
*{{cite journal   |vauthors=Satoh H, Shibata H, Nakano Y, etal |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1166–72 |year= 2002 |pmid= 11883939 |doi= 10.1006/bbrc.2002.6600 }}
*{{cite journal | author=Satoh H, Shibata H, Nakano Y, ''et al.'' |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1166-72 |year= 2002 |pmid= 11883939 |doi= 10.1006/bbrc.2002.6600 }}
*{{cite journal   |vauthors=Chatellard-Causse C, Blot B, Cristina N, etal |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108–15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 }}
*{{cite journal | author=Chatellard-Causse C, Blot B, Cristina N, ''et al.'' |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108-15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 }}
*{{cite journal   |vauthors=Wu Y, Pan S, Luo W, etal |title=Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells |journal=Oncogene |volume=21 |issue= 44 |pages= 6801–8 |year= 2002 |pmid= 12360406 |doi= 10.1038/sj.onc.1205849 }}
*{{cite journal | author=Wu Y, Pan S, Luo W, ''et al.'' |title=Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells. |journal=Oncogene |volume=21 |issue= 44 |pages= 6801-8 |year= 2002 |pmid= 12360406 |doi= 10.1038/sj.onc.1205849 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Vincent O, Rainbow L, Tilburn J, etal |title=YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix |journal=Mol. Cell. Biol. |volume=23 |issue= 5 |pages= 1647–55 |year= 2003 |pmid= 12588984 |doi=10.1128/MCB.23.5.1647-1655.2003  | pmc=151718  }}
*{{cite journal  | author=Vincent O, Rainbow L, Tilburn J, ''et al.'' |title=YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix. |journal=Mol. Cell. Biol. |volume=23 |issue= 5 |pages= 1647-55 |year= 2003 |pmid= 12588984 |doi= }}
*{{cite journal  |vauthors=Schmidt MH, Chen B, Randazzo LM, Bogler O |title=SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion |journal=J. Cell Sci. |volume=116 |issue= Pt 14 |pages= 2845–55 |year= 2004 |pmid= 12771190 |doi= 10.1242/jcs.00522 }}
*{{cite journal | author=Schmidt MH, Chen B, Randazzo LM, Bogler O |title=SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. |journal=J. Cell. Sci. |volume=116 |issue= Pt 14 |pages= 2845-55 |year= 2004 |pmid= 12771190 |doi= 10.1242/jcs.00522 }}
*{{cite journal   |vauthors=Katoh K, Shibata H, Suzuki H, etal |title=The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39104–13 |year= 2003 |pmid= 12860994 |doi= 10.1074/jbc.M301604200 }}
*{{cite journal  | author=Katoh K, Shibata H, Suzuki H, ''et al.'' |title=The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39104-13 |year= 2003 |pmid= 12860994 |doi= 10.1074/jbc.M301604200 }}
*{{cite journal  |vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4  }}
*{{cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793-801 |year= 2003 |pmid= 12927788 |doi=  }}
*{{cite journal   |vauthors=Strack B, Calistri A, Craig S, etal |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding |journal=Cell |volume=114 |issue= 6 |pages= 689–99 |year= 2003 |pmid= 14505569 |doi=10.1016/S0092-8674(03)00653-6 }}
*{{cite journal | author=Strack B, Calistri A, Craig S, ''et al.'' |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689-99 |year= 2003 |pmid= 14505569 |doi= }}
*{{cite journal   |vauthors=von Schwedler UK, Stuchell M, Müller B, etal |title=The protein network of HIV budding |journal=Cell |volume=114 |issue= 6 |pages= 701–13 |year= 2003 |pmid= 14505570 |doi=10.1016/S0092-8674(03)00714-1  }}
*{{cite journal | author=von Schwedler UK, Stuchell M, Müller B, ''et al.'' |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701-13 |year= 2003 |pmid= 14505570 |doi=  }}
*{{cite journal   |vauthors=Martin-Serrano J, Yarovoy A, Perez-Caballero D, etal |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414–9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 | pmc=218772 |bibcode=2003PNAS..10012414M }}
*{{cite journal  | author=Martin-Serrano J, Yarovoy A, Perez-Caballero D, ''et al.'' |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414-9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 }}
*{{cite journal  |vauthors=Peck JW, Bowden ET, Burbelo PD |title=Structure and function of human Vps20 and Snf7 proteins |journal=Biochem. J. |volume=377 |issue= Pt 3 |pages= 693–700 |year= 2004 |pmid= 14583093 |doi= 10.1042/BJ20031347  | pmc=1223912 }}
*{{cite journal  | author=Peck JW, Bowden ET, Burbelo PD |title=Structure and function of human Vps20 and Snf7 proteins. |journal=Biochem. J. |volume=377 |issue= Pt 3 |pages= 693-700 |year= 2004 |pmid= 14583093 |doi= 10.1042/BJ20031347 }}
*{{cite journal  |vauthors=Katoh K, Shibata H, Hatta K, Maki M |title=CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms |journal=Arch. Biochem. Biophys. |volume=421 |issue= 1 |pages= 159–65 |year= 2004 |pmid= 14678797 |doi=10.1016/j.abb.2003.09.038  }}
*{{cite journal | author=Katoh K, Shibata H, Hatta K, Maki M |title=CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. |journal=Arch. Biochem. Biophys. |volume=421 |issue= 1 |pages= 159-65 |year= 2004 |pmid= 14678797 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Matsuo H, Chevallier J, Mayran N, etal |title=Role of LBPA and Alix in multivesicular liposome formation and endosome organization |journal=Science |volume=303 |issue= 5657 |pages= 531–4 |year= 2004 |pmid= 14739459 |doi= 10.1126/science.1092425 |bibcode=2004Sci...303..531M }}
*{{cite journal  | author=Matsuo H, Chevallier J, Mayran N, ''et al.'' |title=Role of LBPA and Alix in multivesicular liposome formation and endosome organization. |journal=Science |volume=303 |issue= 5657 |pages= 531-4 |year= 2004 |pmid= 14739459 |doi= 10.1126/science.1092425 }}
}}
}}
{{refend}}
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{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|PDCD6IP}}
* {{UCSC gene details|PDCD6IP}}
 
{{PDB Gallery|geneid=10015}}
 
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Latest revision as of 19:39, 25 June 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

Programmed cell death 6-interacting protein is a protein that in humans is encoded by the PDCD6IP gene.[1][2]

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.[2]

Interactions

PDCD6IP has been shown to interact with PDCD6.[1][3]

References

  1. ↑ 1.0 1.1 Vito P, Pellegrini L, Guiet C, D'Adamio L (Feb 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J Biol Chem. 274 (3): 1533–40. doi:10.1074/jbc.274.3.1533. PMID 9880530.
  2. ↑ 2.0 2.1 "Entrez Gene: PDCD6IP programmed cell death 6 interacting protein".
  3. ↑ Satoh, Hirokazu; Shibata Hideki; Nakano Yoshimi; Kitaura Yasuyuki; Maki Masatoshi (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. United States. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. ISSN 0006-291X. PMID 11883939.

Further reading

External links



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