PDE4C: Difference between revisions

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'''cAMP-specific 3',5'-cyclic phosphodiesterase 4C''' is an [[enzyme]] that in humans is encoded by the ''PDE4C'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5143| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
| HGNCid = 8782
| Symbol = PDE4C
| AltSymbols =; DPDE1; MGC126222
| OMIM = 600128
| ECnumber = 
| Homologene = 20256
| MGIid = 99556
| GeneAtlas_image1 = PBB_GE_PDE4C_206791_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDE4C_206792_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDE4C_211818_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004114 |text = 3',5'-cyclic-nucleotide phosphodiesterase activity}} {{GNF_GO|id=GO:0004115 |text = 3',5'-cyclic-AMP phosphodiesterase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5143
    | Hs_Ensembl = ENSG00000105650
    | Hs_RefseqProtein = NP_000914
    | Hs_RefseqmRNA = NM_000923
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 18182010
    | Hs_GenLoc_end = 18227229
    | Hs_Uniprot = Q08493
    | Mm_EntrezGene = 110385
    | Mm_Ensembl = ENSMUSG00000031842
    | Mm_RefseqmRNA = NM_201607
    | Mm_RefseqProtein = NP_963901
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 73653515
    | Mm_GenLoc_end = 73679803
    | Mm_Uniprot = 
  }}
}}
'''Phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)''', also known as '''PDE4C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5143| accessdate = }}</ref>


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==Tissue localisation==
PDE4C is predominantly found in peripheral tissues.<ref>{{cite journal|title=Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs|journal=Current Pharmaceutical Design|date=2009|volume=15|issue=14|pages=1688–1698|doi=10.2174/138161209788168092|pmid=19442182|author=Zhang, HT}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Engels P, Sullivan M, Müller T, Lübbert H |title=Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). |journal=FEBS Lett. |volume=358 |issue= 3 |pages= 305-10 |year= 1995 |pmid= 7843419 |doi=  }}
*{{cite journal  | vauthors=Engels P, Sullivan M, Müller T, Lübbert H |title=Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). |journal=FEBS Lett. |volume=358 |issue= 3 |pages= 305–10 |year= 1995 |pmid= 7843419 |doi=10.1016/0014-5793(94)01460-I }}
*{{cite journal  | author=Milatovich A, Bolger G, Michaeli T, Francke U |title=Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 2 |pages= 75-86 |year= 1994 |pmid= 8009369 |doi=  }}
*{{cite journal  | vauthors=Milatovich A, Bolger G, Michaeli T, Francke U |title=Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 2 |pages= 75–86 |year= 1994 |pmid= 8009369 |doi=10.1007/BF02290677 }}
*{{cite journal | author=Bolger G, Michaeli T, Martins T, ''et al.'' |title=A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6558-71 |year= 1993 |pmid= 8413254 |doi=  }}
*{{cite journal   |vauthors=Bolger G, Michaeli T, Martins T, etal |title=A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6558–71 |year= 1993 |pmid= 8413254 |doi= 10.1128/mcb.13.10.6558| pmc=364715 }}
*{{cite journal | author=Obernolte R, Ratzliff J, Baecker PA, ''et al.'' |title=Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. |journal=Biochim. Biophys. Acta |volume=1353 |issue= 3 |pages= 287-97 |year= 1997 |pmid= 9349724 |doi=  }}
*{{cite journal   |vauthors=Obernolte R, Ratzliff J, Baecker PA, etal |title=Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis |journal=Biochim. Biophys. Acta |volume=1353 |issue= 3 |pages= 287–97 |year= 1997 |pmid= 9349724 |doi=  10.1016/s0167-4781(97)00080-8}}
*{{cite journal | author=Owens RJ, Lumb S, Rees-Milton K, ''et al.'' |title=Molecular cloning and expression of a human phosphodiesterase 4C. |journal=Cell. Signal. |volume=9 |issue= 8 |pages= 575-85 |year= 1998 |pmid= 9429761 |doi=  }}
*{{cite journal   |vauthors=Owens RJ, Lumb S, Rees-Milton K, etal |title=Molecular cloning and expression of a human phosphodiesterase 4C |journal=Cell. Signal. |volume=9 |issue= 8 |pages= 575–85 |year= 1998 |pmid= 9429761 |doi=10.1016/S0898-6568(97)00072-7 }}
*{{cite journal  | author=Sullivan M, Olsen AS, Houslay MD |title=Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. |journal=Cell. Signal. |volume=11 |issue= 10 |pages= 735-42 |year= 2000 |pmid= 10574328 |doi=  }}
*{{cite journal  | vauthors=Sullivan M, Olsen AS, Houslay MD |title=Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND |journal=Cell. Signal. |volume=11 |issue= 10 |pages= 735–42 |year= 2000 |pmid= 10574328 |doi=10.1016/S0898-6568(99)00037-6 }}
*{{cite journal | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal | author=Pérez-Torres S, Miró X, Palacios JM, ''et al.'' |title=Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain. |journal=J. Chem. Neuroanat. |volume=20 |issue= 3-4 |pages= 349-74 |year= 2001 |pmid= 11207431 |doi=  }}
*{{cite journal   |vauthors=Pérez-Torres S, Miró X, Palacios JM, etal |title=Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain |journal=J. Chem. Neuroanat. |volume=20 |issue= 3–4 |pages= 349–74 |year= 2001 |pmid= 11207431 |doi=10.1016/S0891-0618(00)00097-1 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Johnson JM, Castle J, Garrett-Engele P, ''et al.'' |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141-4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 }}
*{{cite journal   |vauthors=Johnson JM, Castle J, Garrett-Engele P, etal |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
}}
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Latest revision as of 17:49, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.[1]


Tissue localisation

PDE4C is predominantly found in peripheral tissues.[2]

References

  1. ↑ "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
  2. ↑ Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182.

Further reading



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