PIK3C2A: Difference between revisions

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'''Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide''' is an [[enzyme]] that in humans is encoded by the ''PIK3C2A'' [[gene]].<ref name="pmid9337861">{{cite journal |vauthors=Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD | title = Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin | journal = Biochem J | volume = 326 | issue =  1| pages = 139–47 |date=Nov 1997 | pmid = 9337861 | pmc = 1218647 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5286| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PI3KC2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ar5.
| PDB = {{PDB2|2ar5}}, {{PDB2|2b3r}}, {{PDB2|2iwl}}
| Name = Phosphatidylinositol 3[prime]-kinase, class 2, alpha polypeptide
| HGNCid = 8971
| Symbol = PIK3C2A
| AltSymbols =; CPK; DKFZp686L193; MGC142218; PI3-K-C2(ALPHA); PI3-K-C2A
| OMIM = 603601
| ECnumber = 
| Homologene = 20581
| MGIid = 1203729
| GeneAtlas_image1 = PBB_GE_PIK3C2A_gnf1h00038_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0035005 |text = phosphatidylinositol-4-phosphate 3-kinase activity}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005942 |text = phosphatidylinositol 3[prime]-kinase complex}}
| Process = {{GNF_GO|id=GO:0006661 |text = phosphatidylinositol biosynthetic process}} {{GNF_GO|id=GO:0007154 |text = cell communication}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5286
    | Hs_Ensembl = ENSG00000011405
    | Hs_RefseqProtein = NP_002636
    | Hs_RefseqmRNA = NM_002645
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 17067861
    | Hs_GenLoc_end = 17147864
    | Hs_Uniprot = O00443
    | Mm_EntrezGene = 18704
    | Mm_Ensembl = ENSMUSG00000030660
    | Mm_RefseqmRNA = NM_011083
    | Mm_RefseqProtein = NP_035213
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 116131091
    | Mm_GenLoc_end = 116209669
    | Mm_Uniprot = Q3UQN0
  }}
}}
'''Phosphatidylinositol 3[prime]-kinase, class 2, alpha polypeptide''', also known as '''PI3KC2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PI3KC2A phosphoinositide-3-kinase, class 2, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5286| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the phosphatidylinositol 3[prime]-kinase (PI3K) family. PI3 kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3 kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3 kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.<ref name="entrez">{{cite web | title = Entrez Gene: PI3KC2A (phosphatidylinositol 3[prime]-kinase), class 2, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5286| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of [[Class II PI 3-kinases]]. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
*{{cite journal  | author=Lee C |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–682 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206  |name-list-format=vanc| author2=Liu QH  | author3=Tomkowicz B  | display-authors=3  | last4=Yi  | first4=Y  | last5=Freedman  | first5=BD  | last6=Collman  | first6=RG }}
*{{cite journal | author=Milani D, Mazzoni M, Borgatti P, ''et al.'' |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961-4 |year= 1996 |pmid= 8798481 |doi=  }}
*{{cite journal  | author=Milani D |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–22964 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 |name-list-format=vanc| author2=Mazzoni M  | author3=Borgatti P  | display-authors=3  | last4=Zauli  | first4=G  | last5=Cantley  | first5=L  | last6=Capitani  | first6=S }}
*{{cite journal  | author=Domin J, Pages F, Volinia S, ''et al.'' |title=Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. |journal=Biochem. J. |volume=326 ( Pt 1) |issue= |pages= 139-47 |year= 1997 |pmid= 9337861 |doi= }}
*{{cite journal  |vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–2465 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}
*{{cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457-65 |year= 1997 |pmid= 9341793 |doi=  }}
*{{cite journal  | author=Borgatti P |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–2811 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 |name-list-format=vanc| author2=Zauli G  | author3=Colamussi ML  | display-authors=3 | last4=Gibellini  | first4=Davide  | last5=Previati  | first5=Maurizio  | last6=Cantley  | first6=Lewis L.  | last7=Capitani  | first7=Silvano }}
*{{cite journal  | author=Borgatti P, Zauli G, Colamussi ML, ''et al.'' |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805-11 |year= 1998 |pmid= 9394803 |doi=  }}
*{{cite journal  |vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–337 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}
*{{cite journal  | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332-7 |year= 1998 |pmid= 9446795 |doi= }}
*{{cite journal  | author=Zhang J |title=A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14081–14084 |year= 1998 |pmid= 9603905 |doi=10.1074/jbc.273.23.14081  |name-list-format=vanc| author2=Banfić H | author3=Straforini F  | display-authors=3 | last4=Tosi  | first4=L  | last5=Volinia  | first5=S  | last6=Rittenhouse  | first6=SE }}
*{{cite journal | author=Zhang J, Banfić H, Straforini F, ''et al.'' |title=A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14081-4 |year= 1998 |pmid= 9603905 |doi=  }}
*{{cite journal  | author=Milani D |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells |journal=AIDS |volume=12 |issue= 11 |pages= 1275–1284 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 |name-list-format=vanc| author2=Mazzoni M | author3=Zauli G  | display-authors=3  | last4=Mischiati  | first4=Carlo  | last5=Gibellini  | first5=Davide  | last6=Giacca  | first6=Mauro  | last7=Capitani  | first7=Silvano }}
*{{cite journal  | author=Milani D, Mazzoni M, Zauli G, ''et al.'' |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275-84 |year= 1998 |pmid= 9708406 |doi=  }}
*{{cite journal  | author=Jauliac S |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–3191 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A |name-list-format=vanc| author2=Mazerolles F  | author3=Jabado N  | display-authors=3  | last4=Pallier  | first4=Annaïck  | last5=Bernard  | first5=Frédéric  | last6=Peake  | first6=Jane  | last7=Fischer  | first7=Alain  | last8=Hivroz  | first8=Claire }}
*{{cite journal  | author=Jauliac S, Mazerolles F, Jabado N, ''et al.'' |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183-91 |year= 1998 |pmid= 9808187 |doi= }}
*{{cite journal  | author=Brown RA |title=Insulin activates the alpha isoform of class II phosphoinositide 3-kinase |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14529–14532 |year= 1999 |pmid= 10329640 |doi=10.1074/jbc.274.21.14529  |name-list-format=vanc| author2=Domin J  | author3=Arcaro A  | display-authors=3  | last4=Waterfield  | first4=MD  | last5=Shepherd  | first5=PR  }}
*{{cite journal | author=Brown RA, Domin J, Arcaro A, ''et al.'' |title=Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14529-32 |year= 1999 |pmid= 10329640 |doi=  }}
*{{cite journal  | author=Idriss H |title=HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 12 |pages= 1443–1452 |year= 2000 |pmid= 10641798 |doi=10.1016/S1357-2725(99)00097-7 |name-list-format=vanc| author2=Kawa S | author3=Damuni Z  | display-authors=3  | last4=Thompson  | first4=EB  | last5=Wilson  | first5=SH  }}
*{{cite journal  | author=Idriss H, Kawa S, Damuni Z, ''et al.'' |title=HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system. |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 12 |pages= 1443-52 |year= 2000 |pmid= 10641798 |doi=  }}
*{{cite journal  | author=Domin J |title=The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 11943–11950 |year= 2000 |pmid= 10766823 |doi=10.1074/jbc.275.16.11943  |name-list-format=vanc| author2=Gaidarov I  | author3=Smith ME  | display-authors=3 | last4=Keen  | first4=JH  | last5=Waterfield  | first5=MD  }}
*{{cite journal | author=Domin J, Gaidarov I, Smith ME, ''et al.'' |title=The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles. |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 11943-50 |year= 2000 |pmid= 10766823 |doi=  }}
*{{cite journal  | author=Arcaro A |title=Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3817–3830 |year= 2000 |pmid= 10805725 |doi=10.1128/MCB.20.11.3817-3830.2000  | pmc=85707  |name-list-format=vanc| author2=Zvelebil MJ  | author3=Wallasch C  | display-authors=3  | last4=Ullrich  | first4=A.  | last5=Waterfield  | first5=M. D.  | last6=Domin  | first6=J.  }}
*{{cite journal  | author=Arcaro A, Zvelebil MJ, Wallasch C, ''et al.'' |title=Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3817-30 |year= 2000 |pmid= 10805725 |doi=  }}
*{{cite journal  |vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes |journal=Blood |volume=97 |issue= 2 |pages= 352–358 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352  }}
*{{cite journal  | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352-8 |year= 2001 |pmid= 11154208 |doi=  }}
*{{cite journal  | author=Zauli G |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–491 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com  |name-list-format=vanc| author2=Milani D  | author3=Mirandola P  | display-authors=3  | last4=Mazzoni  | first4=M  | last5=Secchiero  | first5=P  | last6=Miscia  | first6=S  | last7=Capitani  | first7=S }}
*{{cite journal  | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal  |vauthors=Gaidarov I, Smith ME, Domin J, Keen JH |title=The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking |journal=Mol. Cell |volume=7 |issue= 2 |pages= 443–449 |year= 2001 |pmid= 11239472 |doi=10.1016/S1097-2765(01)00191-5  }}
*{{cite journal  | author=Gaidarov I, Smith ME, Domin J, Keen JH |title=The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. |journal=Mol. Cell |volume=7 |issue= 2 |pages= 443-9 |year= 2001 |pmid= 11239472 |doi=  }}
*{{cite journal  | author=Caldwell GM |title=Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14 |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1–2 |pages= 103–107 |year= 2001 |pmid= 11306805 |doi=10.1159/000056877  |name-list-format=vanc| author2=Eddy RL  | author3=Day CD  | display-authors=3  | last4=Haley  | first4=L.H.  | last5=Cooper  | first5=P.R.  | last6=Sait  | first6=S.S.J.  | last7=Hejtmancik  | first7=F.  | last8=Smith  | first8=R.J.H.  | last9=Morton  | first9=C.C.  }}
*{{cite journal | author=Caldwell GM, Eddy RL, Day CD, ''et al.'' |title=Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1-->p14. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1-2 |pages= 103-7 |year= 2001 |pmid= 11306805 |doi=  }}
*{{cite journal  |vauthors=Didichenko SA, Thelen M |title=Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48135–42 |year= 2002 |pmid= 11606566 |doi= 10.1074/jbc.M104610200 }}
*{{cite journal  | author=Didichenko SA, Thelen M |title=Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48135-42 |year= 2002 |pmid= 11606566 |doi= 10.1074/jbc.M104610200 }}
*{{cite journal  | author=Deregibus MC |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–25202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200  |name-list-format=vanc| author2=Cantaluppi V  | author3=Doublier S  | display-authors=3  | last4=Brizzi  | first4=MF  | last5=Deambrosis  | first5=I  | last6=Albini  | first6=A  | last7=Camussi  | first7=G }}
*{{cite journal  | author=Deregibus MC, Cantaluppi V, Doublier S, ''et al.'' |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195-202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 }}
*{{cite journal  |vauthors=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi=  10.4049/jimmunol.169.1.254}}
*{{cite journal  | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254-60 |year= 2002 |pmid= 12077252 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5286}}
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Latest revision as of 18:08, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.[1][2]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of Class II PI 3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.[2]

References

  1. ↑ Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD (Nov 1997). "Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin". Biochem J. 326 (1): 139–47. PMC 1218647. PMID 9337861.
  2. ↑ 2.0 2.1 "Entrez Gene: PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide".

Further reading

  • Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–682. doi:10.1189/jlb.0503206. PMID 12960231.
  • Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–22964. doi:10.1074/jbc.271.38.22961. PMID 8798481.
  • Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–2465. doi:10.1002/eji.1830270946. PMID 9341793.
  • Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–2811. doi:10.1002/eji.1830271110. PMID 9394803.
  • Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–337. doi:10.1006/bbrc.1997.7877. PMID 9446795.
  • Zhang J, Banfić H, Straforini F, et al. (1998). "A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate". J. Biol. Chem. 273 (23): 14081–14084. doi:10.1074/jbc.273.23.14081. PMID 9603905.
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