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{{Infobox_gene}}
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'''Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform''' is an [[enzyme]] that in humans is encoded by the ''PIK3CB'' [[gene]].<ref name="pmid8246984">{{cite journal | vauthors = Hu P, Mondino A, Skolnik EY, Schlessinger J | title = Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7677–88 |date=Jan 1994 | pmid = 8246984 | pmc = 364839 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5291| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphoinositide-3-kinase, catalytic, beta polypeptide
| HGNCid = 8976
| Symbol = PIK3CB
| AltSymbols =; PI3K; DKFZp779K1237; MGC133043; PI3Kbeta; PIK3C1; p110-BETA
| OMIM = 602925
| ECnumber = 
| Homologene = 21250
| MGIid = 1922019
| GeneAtlas_image1 = PBB_GE_PIK3CB_212688_at_tn.png
| GeneAtlas_image2 = PBB_GE_PIK3CB_217620_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0043560 |text = insulin receptor substrate binding}} {{GNF_GO|id=GO:0046934 |text = phosphatidylinositol-4,5-bisphosphate 3-kinase activity}}
| Component = {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0001952 |text = regulation of cell-matrix adhesion}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0040016 |text = embryonic cleavage}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5291
    | Hs_Ensembl = ENSG00000051382
    | Hs_RefseqProtein = NP_006210
    | Hs_RefseqmRNA = NM_006219
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 139856921
    | Hs_GenLoc_end = 139960875
    | Hs_Uniprot = P42338
    | Mm_EntrezGene = 74769
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_029094
    | Mm_RefseqProtein = NP_083370
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Phosphoinositide-3-kinase, catalytic, beta polypeptide''', also known as '''PIK3CB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5291| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5291| accessdate = }}</ref>
| summary_text = Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Katada T, Kurosu H, Okada T, ''et al.'' |title=Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors. |journal=Chem. Phys. Lipids |volume=98 |issue= 1-2 |pages= 79-86 |year= 1999 |pmid= 10358930 |doi=  }}
*{{cite journal   |vauthors=Katada T, Kurosu H, Okada T, etal |title=Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors. |journal=Chem. Phys. Lipids |volume=98 |issue= 1-2 |pages= 79–86 |year= 1999 |pmid= 10358930 |doi=10.1016/S0009-3084(99)00020-1 }}
*{{cite journal | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
*{{cite journal   |vauthors=Lee C, Liu QH, Tomkowicz B, etal |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
*{{cite journal | author=Carpenter CL, Duckworth BC, Auger KR, ''et al.'' |title=Purification and characterization of phosphoinositide 3-kinase from rat liver. |journal=J. Biol. Chem. |volume=265 |issue= 32 |pages= 19704-11 |year= 1991 |pmid= 2174051 |doi=  }}
*{{cite journal   |vauthors=Carpenter CL, Duckworth BC, Auger KR, etal |title=Purification and characterization of phosphoinositide 3-kinase from rat liver. |journal=J. Biol. Chem. |volume=265 |issue= 32 |pages= 19704–11 |year= 1991 |pmid= 2174051 |doi=  }}
*{{cite journal | author=Bonnefoy-Bérard N, Liu YC, von Willebrand M, ''et al.'' |title=Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10142-6 |year= 1995 |pmid= 7479742 |doi= }}
*{{cite journal   |vauthors=Bonnefoy-Bérard N, Liu YC, von Willebrand M, etal |title=Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10142–6 |year= 1995 |pmid= 7479742 |doi=10.1073/pnas.92.22.10142  | pmc=40752  }}
*{{cite journal  | author=Hu P, Schlessinger J |title=Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2577-83 |year= 1994 |pmid= 8139559 |doi=  }}
*{{cite journal  | vauthors=Hu P, Schlessinger J |title=Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2577–83 |year= 1994 |pmid= 8139559 |doi=  10.1128/mcb.14.4.2577| pmc=358625  }}
*{{cite journal | author=Hu P, Mondino A, Skolnik EY, Schlessinger J |title=Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7677-88 |year= 1994 |pmid= 8246984 |doi=  }}
*{{cite journal   |vauthors=Milani D, Mazzoni M, Borgatti P, etal |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 }}
*{{cite journal  | author=Milani D, Mazzoni M, Borgatti P, ''et al.'' |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961-4 |year= 1996 |pmid= 8798481 |doi=  }}
*{{cite journal  | vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}
*{{cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457-65 |year= 1997 |pmid= 9341793 |doi=  }}
*{{cite journal   |vauthors=Borgatti P, Zauli G, Colamussi ML, etal |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 }}
*{{cite journal  | author=Borgatti P, Zauli G, Colamussi ML, ''et al.'' |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805-11 |year= 1998 |pmid= 9394803 |doi=  }}
*{{cite journal  | vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}
*{{cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332-7 |year= 1998 |pmid= 9446795 |doi=  }}
*{{cite journal   |vauthors=Milani D, Mazzoni M, Zauli G, etal |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 }}
*{{cite journal | author=Milani D, Mazzoni M, Zauli G, ''et al.'' |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275-84 |year= 1998 |pmid= 9708406 |doi=  }}
*{{cite journal   |vauthors=Jauliac S, Mazerolles F, Jabado N, etal |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A }}
*{{cite journal | author=Jauliac S, Mazerolles F, Jabado N, ''et al.'' |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183-91 |year= 1998 |pmid= 9808187 |doi=  }}
*{{cite journal   |vauthors=Graness A, Adomeit A, Heinze R, etal |title=A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 32016–22 |year= 1998 |pmid= 9822674 |doi=10.1074/jbc.273.48.32016 }}
*{{cite journal  | author=Graness A, Adomeit A, Heinze R, ''et al.'' |title=A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 32016-22 |year= 1998 |pmid= 9822674 |doi=  }}
*{{cite journal  | vauthors=Sotsios Y, Whittaker GC, Westwick J, Ward SG |title=The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. |journal=J. Immunol. |volume=163 |issue= 11 |pages= 5954–63 |year= 1999 |pmid= 10570282 |doi=  }}
*{{cite journal  | author=Sotsios Y, Whittaker GC, Westwick J, Ward SG |title=The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. |journal=J. Immunol. |volume=163 |issue= 11 |pages= 5954-63 |year= 1999 |pmid= 10570282 |doi= }}
*{{cite journal  | vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352  }}
*{{cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352-8 |year= 2001 |pmid= 11154208 |doi= }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal  | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal  | vauthors=Yang H, Wang X, Raizada MK |title=Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons. |journal=Endocrinology |volume=142 |issue= 8 |pages= 3502–11 |year= 2001 |pmid= 11459796 |doi=10.1210/en.142.8.3502  }}
*{{cite journal  | author=Yang H, Wang X, Raizada MK |title=Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons. |journal=Endocrinology |volume=142 |issue= 8 |pages= 3502-11 |year= 2001 |pmid= 11459796 |doi= }}
*{{cite journal  | vauthors=Steták A, Csermely P, Ullrich A, Kéri G |title=Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 3 |pages= 564–72 |year= 2001 |pmid= 11676480 |doi= 10.1006/bbrc.2001.5811 }}
*{{cite journal | author=Steták A, Csermely P, Ullrich A, Kéri G |title=Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 3 |pages= 564-72 |year= 2001 |pmid= 11676480 |doi= 10.1006/bbrc.2001.5811 }}
*{{cite journal   |vauthors=Ueki K, Yballe CM, Brachmann SM, etal |title=Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 419–24 |year= 2002 |pmid= 11752399 |doi= 10.1073/pnas.012581799 | pmc=117575 }}
*{{cite journal | author=Ueki K, Yballe CM, Brachmann SM, ''et al.'' |title=Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 419-24 |year= 2002 |pmid= 11752399 |doi= 10.1073/pnas.012581799 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:08, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.[1][2]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM][2]

References

  1. ↑ Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. PMC 364839. PMID 8246984.
  2. ↑ 2.0 2.1 "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading



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