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{{Infobox_gene}}
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'''Group IID secretory phospholipase A2''' is an [[enzyme]] that in humans is encoded by the ''PLA2G2D'' [[gene]].<ref name="pmid10455175">{{cite journal |vauthors=Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K | title = Cloning and characterization of novel mouse and human secretory phospholipase A(2)s | journal = J Biol Chem | volume = 274 | issue = 35 | pages = 24973–9 |date=Sep 1999 | pmid = 10455175 | pmc =  | doi =10.1074/jbc.274.35.24973 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLA2G2D phospholipase A2, group IID| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26279| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Phospholipase A2, group IID
| HGNCid = 9033
| Symbol = PLA2G2D
| AltSymbols =; SPLASH; sPLA2S
| OMIM = 605630
| ECnumber = 
| Homologene = 7892
| MGIid = 1341796
| GeneAtlas_image1 = PBB_GE_PLA2G2D_220423_at_tn.png
| Function = {{GNF_GO|id=GO:0004623 |text = phospholipase A2 activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
  | Process = {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26279
    | Hs_Ensembl = ENSG00000117215
    | Hs_RefseqProtein = NP_036532
    | Hs_RefseqmRNA = NM_012400
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 20311019
    | Hs_GenLoc_end = 20318637
    | Hs_Uniprot = Q9UNK4
    | Mm_EntrezGene = 18782
    | Mm_Ensembl = ENSMUSG00000041202
    | Mm_RefseqmRNA = NM_011109
    | Mm_RefseqProtein = NP_035239
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 138047811
    | Mm_GenLoc_end = 138054219
    | Mm_Uniprot = Q3T9Q3
  }}
}}
'''Phospholipase A2, group IID''', also known as '''PLA2G2D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLA2G2D phospholipase A2, group IID| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26279| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi=  }}
*{{cite journal  | author=Schröder HC |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death |journal=Neurotoxicology |volume=19 |issue= 4–5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi= |name-list-format=vanc| author2=Perovic S  | author3=Kavsan V  | display-authors=3  | last4=Ushijima  | first4=H  | last5=Müller  | first5=WE }}
*{{cite journal  | author=Leslie CC |title=Regulation of arachidonic acid availability for eicosanoid production. |journal=Biochem. Cell Biol. |volume=82 |issue= 1 |pages= 1-17 |year= 2004 |pmid= 15052324 |doi= 10.1139/o03-080 }}
*{{cite journal  | author=Leslie CC |title=Regulation of arachidonic acid availability for eicosanoid production |journal=Biochem. Cell Biol. |volume=82 |issue= 1 |pages= 1–17 |year= 2004 |pmid= 15052324 |doi= 10.1139/o03-080 }}
*{{cite journal  | author=Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, ''et al.'' |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1-9 |year= 1997 |pmid= 9377118 |doi=  }}
*{{cite journal  | author=Mavoungou E |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1–9 |year= 1997 |pmid= 9377118 |doi=10.1097/00042560-199709010-00001 |name-list-format=vanc| author2=Georges-Courbot MC  | author3=Poaty-Mavoungou V  | display-authors=3  | last4=Nguyen | first4=HT  | last5=Yaba  | first5=P  | last6=Delicat  | first6=A  | last7=Georges  | first7=AJ  | last8=Russo-Marie  | first8=F }}
*{{cite journal | author=Ishizaki J, Suzuki N, Higashino K, ''et al.'' |title=Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24973-9 |year= 1999 |pmid= 10455175 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Shakhov AN |title=SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency |journal=Genes Immun. |volume=1 |issue= 3 |pages= 191–9 |year= 2001 |pmid= 11196711 |doi= 10.1038/sj.gene.6363659 |name-list-format=vanc| author2=Rubtsov AV  | author3=Lyakhov IG  | display-authors=3  | last4=Tumanov  | first4=A V  | last5=Nedospasov  | first5=S A }}
*{{cite journal  | author=Shakhov AN, Rubtsov AV, Lyakhov IG, ''et al.'' |title=SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. |journal=Genes Immun. |volume=1 |issue= 3 |pages= 191-9 |year= 2001 |pmid= 11196711 |doi= 10.1038/sj.gene.6363659 }}
*{{cite journal  |vauthors=Lindbom J, Ljungman AG, Lindahl M, Tagesson C |title=Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma |journal=J. Interferon Cytokine Res. |volume=22 |issue= 9 |pages= 947–55 |year= 2003 |pmid= 12396716 |doi= 10.1089/10799900260286650 }}
*{{cite journal  | author=Lindbom J, Ljungman AG, Lindahl M, Tagesson C |title=Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 9 |pages= 947-55 |year= 2003 |pmid= 12396716 |doi= 10.1089/10799900260286650 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697  |name-list-format=vanc| author2=Gurney AL  | author3=Abaya E  | display-authors=3  | last4=Baker  | first4=K  | last5=Baldwin  | first5=D  | last6=Brush  | first6=J  | last7=Chen  | first7=J  | last8=Chow  | first8=B  | last9=Chui  | first9=C }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  |vauthors=Eckey R, Menschikowski M, Lattke P, Jaross W |title=Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA |journal=Inflammation |volume=28 |issue= 2 |pages= 59–65 |year= 2005 |pmid= 15379211 |doi=10.1023/B:IFLA.0000033021.44105.9c }}
*{{cite journal  | author=Eckey R, Menschikowski M, Lattke P, Jaross W |title=Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA. |journal=Inflammation |volume=28 |issue= 2 |pages= 59-65 |year= 2005 |pmid= 15379211 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Takabatake N |title=A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease |journal=Am. J. Respir. Crit. Care Med. |volume=172 |issue= 9 |pages= 1097–104 |year= 2006 |pmid= 16002569 |doi= 10.1164/rccm.200503-319OC |name-list-format=vanc| author2=Sata M  | author3=Inoue S  | display-authors=3  | last4=Shibata  | first4=Y  | last5=Abe  | first5=S  | last6=Wada  | first6=T  | last7=Machiya  | first7=J  | last8=Ji  | first8=G  | last9=Matsuura  | first9=T }}
*{{cite journal  | author=Takabatake N, Sata M, Inoue S, ''et al.'' |title=A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease. |journal=Am. J. Respir. Crit. Care Med. |volume=172 |issue= 9 |pages= 1097-104 |year= 2006 |pmid= 16002569 |doi= 10.1164/rccm.200503-319OC }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  |vauthors=Lindbom J, Ljungman AG, Tagesson C |title=Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide |journal=Inflammation |volume=29 |issue= 2–3 |pages= 108–117 |year= 2007 |pmid= 16897354 |doi= 10.1007/s10753-006-9007-x }}
*{{cite journal  | author=Lindbom J, Ljungman AG, Tagesson C |title=Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide. |journal=Inflammation |volume=29 |issue= 2-3 |pages= 108-117 |year= 2007 |pmid= 16897354 |doi= 10.1007/s10753-006-9007-x }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:15, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.[1][2]


References

  1. ↑ Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K (Sep 1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s". J Biol Chem. 274 (35): 24973–9. doi:10.1074/jbc.274.35.24973. PMID 10455175.
  2. ↑ "Entrez Gene: PLA2G2D phospholipase A2, group IID".

Further reading



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