Primary sclerosing cholangitis causes: Difference between revisions

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{{Primary sclerosing cholangitis}}
{{Primary sclerosing cholangitis}}
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==Overview==
==Overview==
The cause of primary sclerosing cholangitis is unclear and not fully understood. However, [[Genetics|genetic]] and environmental factors are thought to contribute to the development of the disease.
==Causes==
==Causes==
The cause of primary sclerosing cholangitis is unclear and not fully understood. However, [[Genetics|genetic]] and environmental factors are thought to contribute to the development of the disease.<ref name="pmid27653566">{{cite journal |vauthors=Lazaridis KN, LaRusso NF |title=Primary Sclerosing Cholangitis |journal=N. Engl. J. Med. |volume=375 |issue=12 |pages=1161–70 |year=2016 |pmid=27653566 |doi=10.1056/NEJMra1506330 |url=}}</ref><ref name="pmid17440311">{{cite journal |vauthors=Geonzon-Gonzales MR |title=Primary sclerosing cholangitis |journal=Gastroenterol Nurs |volume=30 |issue=2 |pages=102–5; quiz 105–7 |year=2007 |pmid=17440311 |doi=10.1097/01.SGA.0000267929.62298.64 |url=}}</ref>


The cause(s) for PSC are unknown. It is often considered to be an [[autoimmunity|autoimmune disorder]]. PSC is associated with [[ulcerative colitis]]. It is assumed that these diseases share a common cause.
Ulcerative colitis is a systemic disease that affects many areas of the body. PSC is often listed as a manifestation of ulcerative colitis outside the colon. PSC differs from these manifestations in that, unlike most other manifestations, PSC continues in spite of surgical removal of the colon.[http://www.acg.gi.org] This suggests that, while the cause of ulcerative colitis, and most of its manifestations, is in the colon, the cause of PSC is located outside the colon.
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 17:42, 5 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

The cause of primary sclerosing cholangitis is unclear and not fully understood. However, genetic and environmental factors are thought to contribute to the development of the disease.

Causes

The cause of primary sclerosing cholangitis is unclear and not fully understood. However, genetic and environmental factors are thought to contribute to the development of the disease.[1][2]

References

  1. Lazaridis KN, LaRusso NF (2016). "Primary Sclerosing Cholangitis". N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
  2. Geonzon-Gonzales MR (2007). "Primary sclerosing cholangitis". Gastroenterol Nurs. 30 (2): 102–5, quiz 105–7. doi:10.1097/01.SGA.0000267929.62298.64. PMID 17440311.


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