PMS1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''PMS1 protein homolog 1''' is a [[protein]] that in humans is encoded by the ''PMS1'' [[gene]].<ref name="pmid8072530">{{cite journal | vauthors = Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM | title = Mutations of two PMS homologues in hereditary nonpolyposis colon cancer | journal = Nature | volume = 371 | issue = 6492 | pages = 75–80 | date = Sep 1994 | pmid = 8072530 | pmc =  | doi = 10.1038/371075a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5378| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PMS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cs1.
| PDB = {{PDB2|2cs1}}
| Name = PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
| HGNCid = 9121
| Symbol = PMS1
| AltSymbols =; DKFZp781M0253; HNPCC3; PMSL1; hPMS1
| OMIM = 600258
| ECnumber = 
| Homologene = 449
| MGIid = 1202302
| GeneAtlas_image1 = PBB_GE_PMS1_213677_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006298 |text = mismatch repair}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5378
    | Hs_Ensembl = ENSG00000064933
    | Hs_RefseqProtein = NP_000525
    | Hs_RefseqmRNA = NM_000534
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 190357355
    | Hs_GenLoc_end = 190450599
    | Hs_Uniprot = P54277
    | Mm_EntrezGene = 227099
    | Mm_Ensembl = ENSMUSG00000026098
    | Mm_RefseqmRNA = NM_153556
    | Mm_RefseqProtein = NP_705784
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 53133732
    | Mm_GenLoc_end = 53241541
    | Mm_Uniprot = 
  }}
}}
'''PMS1 postmeiotic segregation increased 1 (S. cerevisiae)''', also known as '''PMS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5378| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms [[protein dimer|heterodimers]] with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5378| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kolodner R | title = Biochemistry and genetics of eukaryotic mismatch repair | journal = Genes Dev. | volume = 10 | issue = 12 | pages = 1433–42 | year = 1996 | pmid = 8666228 | doi = 10.1101/gad.10.12.1433 }}
| citations =
* {{cite journal | vauthors = Horii A, Han HJ, Sasaki S, Shimada M, Nakamura Y | title = Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes | journal = Biochem. Biophys. Res. Commun. | volume = 204 | issue = 3 | pages = 1257–64 | year = 1994 | pmid = 7980603 | doi = 10.1006/bbrc.1994.2598 }}
*{{cite journal | author=Kolodner R |title=Biochemistry and genetics of eukaryotic mismatch repair. |journal=Genes Dev. |volume=10 |issue= 12 |pages= 1433-42 |year= 1996 |pmid= 8666228 |doi= }}
* {{cite journal | vauthors = Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD | title = Mutation of a mutL homolog in hereditary colon cancer | journal = Science | volume = 263 | issue = 5153 | pages = 1625–9 | year = 1994 | pmid = 8128251 | doi = 10.1126/science.8128251 }}
*{{cite journal | author=Horii A, Han HJ, Sasaki S, ''et al.'' |title=Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. |journal=Biochem. Biophys. Res. Commun. |volume=204 |issue= 3 |pages= 1257-64 |year= 1994 |pmid= 7980603 |doi= 10.1006/bbrc.1994.2598 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Nicolaides NC, Papadopoulos N, Liu B, ''et al.'' |title=Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. |journal=Nature |volume=371 |issue= 6492 |pages= 75-80 |year= 1994 |pmid= 8072530 |doi= 10.1038/371075a0 }}
* {{cite journal | vauthors = Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K | title = Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1 | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 3 | pages = 738–43 | year = 1998 | pmid = 9500994 | doi = 10.1006/bbrc.1998.8165 }}
*{{cite journal  | author=Papadopoulos N, Nicolaides NC, Wei YF, ''et al.'' |title=Mutation of a mutL homolog in hereditary colon cancer. |journal=Science |volume=263 |issue= 5153 |pages= 1625-9 |year= 1994 |pmid= 8128251 |doi= }}
* {{cite journal | vauthors = Korabiowska M, Brinck U, Ruschenburg I, Dengler H, Droese M, Berger H | title = Expression of DNA mismatch repair genes in naevi | journal = In Vivo | volume = 13 | issue = 3 | pages = 251–4 | year = 1999 | pmid = 10459502 | doi =  }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Wang Q, Lasset C, Desseigne F, Saurin JC, Maugard C, Navarro C, Ruano E, Descos L, Trillet-Lenoir V, Bosset JF, Puisieux A | title = Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer | journal = Hum. Genet. | volume = 105 | issue = 1–2 | pages = 79–85 | year = 1999 | pmid = 10480359 | doi = 10.1007/s004390051067 }}
*{{cite journal | author=Yanagisawa Y, Ito E, Iwahashi Y, ''et al.'' |title=Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 3 |pages= 738-43 |year= 1998 |pmid= 9500994 |doi= 10.1006/bbrc.1998.8165 }}
* {{cite journal | vauthors = Matton N, Simonetti J, Williams K | title = Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17808–13 | year = 2000 | pmid = 10748159 | doi = 10.1074/jbc.M909794199 }}
*{{cite journal | author=Korabiowska M, Brinck U, Ruschenburg I, ''et al.'' |title=Expression of DNA mismatch repair genes in naevi. |journal=In Vivo |volume=13 |issue= 3 |pages= 251-4 |year= 1999 |pmid= 10459502 |doi=  }}
* {{cite journal | vauthors = Alvarez Soria MA, Justesen J, Hansen LL | title = Assignment of the human postmeiotic segregation increased (S. cerevisiae) 1 (PMS1) to chromosome 2q31.1 by radiation hybrid mapping | journal = Cytogenet. Cell Genet. | volume = 88 | issue = 3–4 | pages = 200–1 | year = 2000 | pmid = 10828585 | doi = 10.1159/000015546 }}
*{{cite journal | author=Wang Q, Lasset C, Desseigne F, ''et al.'' |title=Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. |journal=Hum. Genet. |volume=105 |issue= 1-2 |pages= 79-85 |year= 1999 |pmid= 10480359 |doi= }}
* {{cite journal | vauthors = Kondo E, Horii A, Fukushige S | title = The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2 | journal = Nucleic Acids Res. | volume = 29 | issue = 8 | pages = 1695–702 | year = 2001 | pmid = 11292842 | pmc = 31313 | doi = 10.1093/nar/29.8.1695 }}
*{{cite journal | author=Matton N, Simonetti J, Williams K |title=Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17808-13 |year= 2000 |pmid= 10748159 |doi= 10.1074/jbc.M909794199 }}
* {{cite journal | vauthors = Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S | title = hMutSα forms an ATP-dependent complex with hMutLα and hMutLβ on DNA | journal = Nucleic Acids Res. | volume = 30 | issue = 3 | pages = 711–8 | year = 2002 | pmid = 11809883 | pmc = 100294 | doi = 10.1093/nar/30.3.711 }}
*{{cite journal | author=Alvarez Soria MA, Justesen J, Hansen LL |title=Assignment of the human postmeiotic segregation increased (S. cerevisiae) 1 (PMS1) to chromosome 2q31.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 200-1 |year= 2000 |pmid= 10828585 |doi= }}
* {{cite journal | vauthors = Kotoula V, Hytiroglou P, Kaloutsi V, Barbanis S, Kouidou S, Papadimitriou CS | title = Mismatch repair gene expression in malignant lymphoproliferative disorders of B-cell origin | journal = Leuk. Lymphoma | volume = 43 | issue = 2 | pages = 393–9 | year = 2003 | pmid = 11999575 | doi = 10.1080/10428190290006215 }}
*{{cite journal | author=Kondo E, Horii A, Fukushige S |title=The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2. |journal=Nucleic Acids Res. |volume=29 |issue= 8 |pages= 1695-702 |year= 2001 |pmid= 11292842 |doi= }}
* {{cite journal | vauthors = Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S | title = N-terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα | journal = Nucleic Acids Res. | volume = 31 | issue = 12 | pages = 3217–26 | year = 2003 | pmid = 12799449 | pmc = 162253 | doi = 10.1093/nar/gkg420 }}
*{{cite journal | author=Plotz G, Raedle J, Brieger A, ''et al.'' |title=hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. |journal=Nucleic Acids Res. |volume=30 |issue= 3 |pages= 711-8 |year= 2002 |pmid= 11809883 |doi= }}
* {{cite journal | vauthors = Luo Y, Lin FT, Lin WC | title = ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA Damage | journal = Mol. Cell. Biol. | volume = 24 | issue = 14 | pages = 6430–44 | year = 2004 | pmid = 15226443 | pmc = 434232 | doi = 10.1128/MCB.24.14.6430-6444.2004 }}
*{{cite journal | author=Kotoula V, Hytiroglou P, Kaloutsi V, ''et al.'' |title=Mismatch repair gene expression in malignant lymphoproliferative disorders of B-cell origin. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 393-9 |year= 2003 |pmid= 11999575 |doi=  }}
* {{cite journal | vauthors = Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y | title = Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis | journal = Int. J. Cancer | volume = 116 | issue = 6 | pages = 925–33 | year = 2005 | pmid = 15856462 | doi = 10.1002/ijc.21118 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Plotz G, Raedle J, Brieger A, ''et al.'' |title=N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha. |journal=Nucleic Acids Res. |volume=31 |issue= 12 |pages= 3217-26 |year= 2003 |pmid= 12799449 |doi= }}
* {{cite journal | vauthors = Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J | title = Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2 | journal = J. Biol. Chem. | volume = 282 | issue = 5 | pages = 2976–86 | year = 2007 | pmid = 17148452 | doi = 10.1074/jbc.M609989200 }}
*{{cite journal | author=Luo Y, Lin FT, Lin WC |title=ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. |journal=Mol. Cell. Biol. |volume=24 |issue= 14 |pages= 6430-44 |year= 2004 |pmid= 15226443 |doi= 10.1128/MCB.24.14.6430-6444.2004 }}
*{{cite journal | author=Okada T, Noji S, Goto Y, ''et al.'' |title=Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. |journal=Int. J. Cancer |volume=116 |issue= 6 |pages= 925-33 |year= 2005 |pmid= 15856462 |doi= 10.1002/ijc.21118 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Cannavo E, Gerrits B, Marra G, ''et al.'' |title=Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. |journal=J. Biol. Chem. |volume=282 |issue= 5 |pages= 2976-86 |year= 2007 |pmid= 17148452 |doi= 10.1074/jbc.M609989200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5378}}
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 18:21, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PMS1 protein homolog 1 is a protein that in humans is encoded by the PMS1 gene.[1][2]

Function

The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.[2]

References

  1. ↑ Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM (Sep 1994). "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer". Nature. 371 (6492): 75–80. doi:10.1038/371075a0. PMID 8072530.
  2. ↑ 2.0 2.1 "Entrez Gene: PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PMS1&oldid=1412705"