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{{Infobox_gene}}
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'''DNA polymerase delta subunit 2''' is an [[enzyme]] that in humans is encoded by the ''POLD2'' [[gene]].<ref name="pmid8530069">{{cite journal |vauthors=Zhang J, Tan CK, McMullen B, Downey KM, So AG | title = Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2) | journal = Genomics | volume = 29 | issue = 1 | pages = 179–86 |date=Feb 1996 | pmid = 8530069 | pmc =  | doi = 10.1006/geno.1995.1229 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5425| accessdate = }}</ref> It is a component of the  [[DNA polymerase delta]] complex.
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Polymerase (DNA directed), delta 2, regulatory subunit 50kDa
| HGNCid = 9176
| Symbol = POLD2
| AltSymbols =;
| OMIM = 600815
| ECnumber = 
| Homologene = 4538
| MGIid = 1097163
| GeneAtlas_image1 = PBB_GE_POLD2_201115_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003887 |text = DNA-directed DNA polymerase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5425
    | Hs_Ensembl = ENSG00000106628
    | Hs_RefseqProtein = NP_006221
    | Hs_RefseqmRNA = NM_006230
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 44120812
    | Hs_GenLoc_end = 44128238
    | Hs_Uniprot = P49005
    | Mm_EntrezGene = 18972
    | Mm_Ensembl = ENSMUSG00000020471
    | Mm_RefseqmRNA = NM_008894
    | Mm_RefseqProtein = NP_032920
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 5772183
    | Mm_GenLoc_end = 5778295
    | Mm_Uniprot = Q99J61
  }}
}}
'''Polymerase (DNA directed), delta 2, regulatory subunit 50kDa''', also known as '''POLD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5425| accessdate = }}</ref>


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==Interactions==
POLD2 has been shown to [[Protein-protein interaction|interact]] with [[PCNA]].<ref name=pmid11986310>{{cite journal |last=Lu |first=Xiaoqing |authorlink= |author2=Tan Cheng-Keat |author3=Zhou Jin-Qiu |author4=You Min |author5=Carastro L Michael |author6=Downey Kathleen M |author7=So Antero G  |date=Jul 2002 |title=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |journal=J. Biol. Chem. |volume=277 |issue=27 |pages=24340–5 |publisher= |location = United States| issn = 0021-9258| pmid = 11986310 |doi = 10.1074/jbc.M200065200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
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| citations =  
| citations =  
*{{cite journal  | author=Zhang J, Tan CK, McMullen B, ''et al.'' |title=Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2). |journal=Genomics |volume=29 |issue= 1 |pages= 179-86 |year= 1996 |pmid= 8530069 |doi= 10.1006/geno.1995.1229 }}
*{{cite journal  |vauthors=Hindges R, Hübscher U |title=Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). |journal=Genomics |volume=44 |issue= 1 |pages= 45–51 |year= 1997 |pmid= 9286699 |doi= 10.1006/geno.1997.4838 }}
*{{cite journal  | author=Hindges R, Hübscher U |title=Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). |journal=Genomics |volume=44 |issue= 1 |pages= 45-51 |year= 1997 |pmid= 9286699 |doi= 10.1006/geno.1997.4838 }}
*{{cite journal  | author=Hisama FM |title=WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts |journal=Cancer Res. |volume=60 |issue= 9 |pages= 2372–6 |year= 2000 |pmid= 10811112 |doi=  |name-list-format=vanc| author2=Chen YH | author3=Meyn MS | display-authors=3  | last4=Oshima  | first4=J  | last5=Weissman  | first5=SM  }}
*{{cite journal | author=Hisama FM, Chen YH, Meyn MS, ''et al.'' |title=WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. |journal=Cancer Res. |volume=60 |issue= 9 |pages= 2372-6 |year= 2000 |pmid= 10811112 |doi=  }}
*{{cite journal  | author=Mo J |title=Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA |journal=Biochemistry |volume=39 |issue= 24 |pages= 7245–54 |year= 2000 |pmid= 10852724 |doi=10.1021/bi0000871 |name-list-format=vanc| author2=Liu L  | author3=Leon A | display-authors=3  | last4=Mazloum  | first4=Nayef  | last5=Lee  | first5=Marietta Y. W. T.  }}
*{{cite journal  | author=Mo J, Liu L, Leon A, ''et al.'' |title=Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. |journal=Biochemistry |volume=39 |issue= 24 |pages= 7245-54 |year= 2000 |pmid= 10852724 |doi= }}
*{{cite journal  |vauthors=Perez A, Leon A, Lee MY |title=Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1–2 |pages= 231–6 |year= 2000 |pmid= 10978529 |doi= 10.1016/s0167-4781(00)00153-6}}
*{{cite journal | author=Perez A, Leon A, Lee MY |title=Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 231-6 |year= 2000 |pmid= 10978529 |doi= }}
*{{cite journal  | author=Szekely AM |title=Werner protein recruits DNA polymerase δ to the nucleolus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 21 |pages= 11365–70 |year= 2000 |pmid= 11027336 |doi= 10.1073/pnas.97.21.11365  | pmc=17206  |name-list-format=vanc| author2=Chen YH  | author3=Zhang C  | display-authors=3  | last4=Oshima  | first4=J  | last5=Weissman  | first5=SM |bibcode=2000PNAS...9711365S}}
*{{cite journal  | author=Szekely AM, Chen YH, Zhang C, ''et al.'' |title=Werner protein recruits DNA polymerase delta to the nucleolus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 21 |pages= 11365-70 |year= 2000 |pmid= 11027336 |doi= 10.1073/pnas.97.21.11365 }}
*{{cite journal  |vauthors=He H, Tan CK, Downey KM, So AG |title=A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 21 |pages= 11979–84 |year= 2001 |pmid= 11593007 |doi= 10.1073/pnas.221452098  | pmc=59753 |bibcode=2001PNAS...9811979H }}
*{{cite journal | author=He H, Tan CK, Downey KM, So AG |title=A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 21 |pages= 11979-84 |year= 2001 |pmid= 11593007 |doi= 10.1073/pnas.221452098 }}
*{{cite journal  | author=Lu X |title=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24340–5 |year= 2002 |pmid= 11986310 |doi= 10.1074/jbc.M200065200  |name-list-format=vanc| author2=Tan CK  | author3=Zhou JQ | display-authors=3  | last4=You  | first4=M  | last5=Carastro  | first5=LM  | last6=Downey  | first6=KM  | last7=So  | first7=AG }}
*{{cite journal  | author=Lu X, Tan CK, Zhou JQ, ''et al.'' |title=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24340-5 |year= 2002 |pmid= 11986310 |doi= 10.1074/jbc.M200065200 }}
*{{cite journal  | author=Ohta S |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200  |name-list-format=vanc| author2=Shiomi Y  | author3=Sugimoto K  | display-authors=3  | last4=Obuse  | first4=C  | last5=Tsurimoto  | first5=T }}
*{{cite journal  | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner | first7=L | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Liu L |title=Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10041–7 |year= 2003 |pmid= 12522211 |doi= 10.1074/jbc.M208694200  |name-list-format=vanc| author2=Rodriguez-Belmonte EM | author3=Mazloum N  | display-authors=3  | last4=Xie  | first4=B  | last5=Lee  | first5=MY }}
*{{cite journal | author=Liu L, Rodriguez-Belmonte EM, Mazloum N, ''et al.'' |title=Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10041-7 |year= 2003 |pmid= 12522211 |doi= 10.1074/jbc.M208694200 }}
*{{cite journal | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961  |name-list-format=vanc| author2=Cheung J  | author3=MacDonald JR  | display-authors=3  | last4=Osborne  | first4=LR  | last5=Nakabayashi  | first5=K  | last6=Herbrick  | first6=JA  | last7=Carson  | first7=AR  | last8=Parker-Katiraee  | first8=L  | last9=Skaug  | first9=J |bibcode=2003Sci...300..767S}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Tsurimoto T |title=Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta |journal=Genes Cells |volume=10 |issue= 1 |pages= 13–22 |year= 2005 |pmid= 15670210 |doi= 10.1111/j.1365-2443.2004.00812.x  |name-list-format=vanc| author2=Shinozaki A  | author3=Yano M  | display-authors=3  | last4=Seki  | first4=Masayuki  | last5=Enomoto  | first5=Takemi }}
*{{cite journal | author=Tsurimoto T, Shinozaki A, Yano M, ''et al.'' |title=Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. |journal=Genes Cells |volume=10 |issue= 1 |pages= 13-22 |year= 2005 |pmid= 15670210 |doi= 10.1111/j.1365-2443.2004.00812.x }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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{{DNA replication}}
 
 
{{gene-7-stub}}

Latest revision as of 19:45, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.[1][2] It is a component of the DNA polymerase delta complex.


Interactions

POLD2 has been shown to interact with PCNA.[3]

References

  1. ↑ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
  2. ↑ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
  3. ↑ Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. United States. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310.

Further reading



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