PPHLN1: Difference between revisions

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'''Periphilin-1''' is a [[protein]] that in humans is encoded by the ''PPHLN1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPHLN1 periphilin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51535| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Periphilin 1
| HGNCid = 19369
| Symbol = PPHLN1
| AltSymbols =; HSPC206; HSPC232; MGC48786
| OMIM = 608150
| ECnumber = 
| Homologene = 9533
| MGIid = 1917029
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0031424 |text = keratinization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51535
    | Hs_Ensembl = ENSG00000134283
    | Hs_RefseqProtein = NP_057572
    | Hs_RefseqmRNA = NM_016488
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 40918516
    | Hs_GenLoc_end = 41126687
    | Hs_Uniprot = Q8NEY8
    | Mm_EntrezGene = 223828
    | Mm_Ensembl = ENSMUSG00000036167
    | Mm_RefseqmRNA = NM_146062
    | Mm_RefseqProtein = NP_666174
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 93226538
    | Mm_GenLoc_end = 93319690
    | Mm_Uniprot = Q8K2H1
  }}
}}
'''Periphilin 1''', also known as '''PPHLN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPHLN1 periphilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51535| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: PPHLN1 periphilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51535| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: PPHLN1 periphilin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51535| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 }}
*{{cite journal | author=Linē A, Stengrēvics A, Slucka Z, ''et al.'' |title=Serological identification and expression analysis of gastric cancer-associated genes. |journal=Br. J. Cancer |volume=86 |issue= 11 |pages= 1824-30 |year= 2002 |pmid= 12087473 |doi= 10.1038/sj.bjc.6600321 }}
*{{cite journal   |vauthors=Linē A, Stengrēvics A, Slucka Z, etal |title=Serological identification and expression analysis of gastric cancer-associated genes. |journal=Br. J. Cancer |volume=86 |issue= 11 |pages= 1824–30 |year= 2002 |pmid= 12087473 |doi= 10.1038/sj.bjc.6600321 | pmc=2375403 }}
*{{cite journal  | author=Kazerounian S, Uitto J, Aho S |title=Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. |journal=Exp. Dermatol. |volume=11 |issue= 5 |pages= 428-38 |year= 2003 |pmid= 12366696 |doi=  }}
*{{cite journal  | vauthors=Kazerounian S, Uitto J, Aho S |title=Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. |journal=Exp. Dermatol. |volume=11 |issue= 5 |pages= 428–38 |year= 2003 |pmid= 12366696 |doi=10.1034/j.1600-0625.2002.110506.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Kazerounian S, Aho S |title=Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36707-17 |year= 2003 |pmid= 12853457 |doi= 10.1074/jbc.M303896200 }}
*{{cite journal  | vauthors=Kazerounian S, Aho S |title=Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36707–17 |year= 2003 |pmid= 12853457 |doi= 10.1074/jbc.M303896200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Kurita M, Suzuki H, Masai H, ''et al.'' |title=Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 2 |pages= 554-61 |year= 2004 |pmid= 15474462 |doi= 10.1016/j.bbrc.2004.09.083 }}
*{{cite journal   |vauthors=Kurita M, Suzuki H, Masai H, etal |title=Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 2 |pages= 554–61 |year= 2004 |pmid= 15474462 |doi= 10.1016/j.bbrc.2004.09.083 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Mizrachi-Koren M, Geiger D, Indelman M, ''et al.'' |title=Identification of a novel locus associated with congenital recessive ichthyosis on 12p11.2-q13. |journal=J. Invest. Dermatol. |volume=125 |issue= 3 |pages= 456-62 |year= 2005 |pmid= 16117785 |doi= 10.1111/j.0022-202X.2005.23777.x }}
*{{cite journal   |vauthors=Mizrachi-Koren M, Geiger D, Indelman M, etal |title=Identification of a novel locus associated with congenital recessive ichthyosis on 12p11.2-q13. |journal=J. Invest. Dermatol. |volume=125 |issue= 3 |pages= 456–62 |year= 2005 |pmid= 16117785 |doi= 10.1111/j.0022-202X.2005.23777.x }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:31, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Periphilin-1 is a protein that in humans is encoded by the PPHLN1 gene.[1]

The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PPHLN1 periphilin 1".

Further reading



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