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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''PML-RARA-regulated adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''PRAM1'' [[gene]].<ref name="pmid11301322">{{cite journal | vauthors = Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G | title = PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells | journal = J Biol Chem | volume = 276 | issue = 25 | pages = 22375–81 | date = Jun 2001 | pmid = 11301322 | pmc =  | doi = 10.1074/jbc.M011683200 }}</ref><ref name="pmid15572693">{{cite journal | vauthors = Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ | title = PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function | journal = Mol Cell Biol | volume = 24 | issue = 24 | pages = 10923–32 | date = Dec 2004 | pmid = 15572693 | pmc = 533979 | doi = 10.1128/MCB.24.24.10923-10932.2004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PML-RARA regulated adaptor molecule 1
| HGNCid = 30091
| Symbol = PRAM1
| AltSymbols =; MGC39864; PRAM-1
| OMIM = 606466
| ECnumber = 
| Homologene = 12963
| MGIid = 3576625
| GeneAtlas_image1 = PBB_GE_PRAM1_gnf1h00620_at_tn.png
| Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84106
    | Hs_Ensembl = ENSG00000133246
    | Hs_RefseqProtein = NP_115528
    | Hs_RefseqmRNA = NM_032152
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 8460941
    | Hs_GenLoc_end = 8473495
    | Hs_Uniprot = Q96QH2
    | Mm_EntrezGene = 378460
    | Mm_Ensembl = ENSMUSG00000032739
    | Mm_RefseqmRNA = NM_001002842
    | Mm_RefseqProtein = NP_001002842
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 33247152
    | Mm_GenLoc_end = 33252263
    | Mm_Uniprot = Q6BCL1
  }}
}}
'''PML-RARA regulated adaptor molecule 1''', also known as '''PRAM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).<ref name="entrez">{{cite web | title = Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PRAM1 has been shown to [[Protein-protein interaction|interact]] with [[TRIM27]].<ref name=pmid9570750>{{cite journal | vauthors = Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD | title = Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML | journal = J. Cell Sci. | volume = 111 | issue = 10 | pages = 1319–29 | date = May 1998 | pmid = 9570750 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS | title = PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia | journal = Oncogene | volume = 13 | issue = 5 | pages = 971–82 | year = 1996 | pmid = 8806687 | doi =  }}
| citations =
* {{cite journal | vauthors = Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD | title = Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML | journal = J. Cell Sci. | volume = 111 | issue = 10 | pages = 1319–29 | year = 1998 | pmid = 9570750 | doi =  }}
*{{cite journal | author=Boddy MN, Howe K, Etkin LD, ''et al.'' |title=PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. |journal=Oncogene |volume=13 |issue= 5 |pages= 971-82 |year= 1996 |pmid= 8806687 |doi=  }}
* {{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Mol. Cell | volume = 7 | issue = 6 | pages = 1233–43 | year = 2001 | pmid = 11430826 | doi = 10.1016/S1097-2765(01)00257-X }}
*{{cite journal | author=Cao T, Duprez E, Borden KL, ''et al.'' |title=Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. |journal=J. Cell. Sci. |volume=111 ( Pt 10) |issue= |pages= 1319-29 |year= 1998 |pmid= 9570750 |doi=  }}
* {{cite journal | vauthors = Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG | title = PRAM-1 potentiates arsenic trioxide-induced JNK activation | journal = J. Biol. Chem. | volume = 280 | issue = 10 | pages = 9043–8 | year = 2005 | pmid = 15637062 | doi = 10.1074/jbc.M413564200 }}
*{{cite journal | author=Moog-Lutz C, Peterson EJ, Lutz PG, ''et al.'' |title=PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22375-81 |year= 2001 |pmid= 11301322 |doi= 10.1074/jbc.M011683200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Khan MM, Nomura T, Kim H, ''et al.'' |title=Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. |journal=Mol. Cell |volume=7 |issue= 6 |pages= 1233-43 |year= 2001 |pmid= 11430826 |doi=  }}
* {{cite journal | vauthors = Rossi V, Levati L, Biondi A | title = Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR | journal = Methods Mol. Med. | volume = 125 | issue =  | pages = 115–26 | year = 2006 | pmid = 16502581 | doi = 10.1385/1-59745-017-0:115 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mokany E, Todd AV, Fuery CJ, Applegate TL | title = Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR | journal = Methods Mol. Med. | volume = 125 | issue =  | pages = 127–47 | year = 2006 | pmid = 16502582 | doi = 10.1385/1-59745-017-0:127 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Heuer K, Sylvester M, Kliche S, Pusch R, Thiemke K, Schraven B, Freund C | title = Lipid-binding hSH3 domains in immune cell adapter proteins | journal = J. Mol. Biol. | volume = 361 | issue = 1 | pages = 94–104 | year = 2006 | pmid = 16831444 | doi = 10.1016/j.jmb.2006.06.004 }}
*{{cite journal | author=Clemens RA, Newbrough SA, Chung EY, ''et al.'' |title=PRAM-1 is required for optimal integrin-dependent neutrophil function. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10923-32 |year= 2004 |pmid= 15572693 |doi= 10.1128/MCB.24.24.10923-10932.2004 }}
*{{cite journal  | author=Denis FM, Benecke A, Di Gioia Y, ''et al.'' |title=PRAM-1 potentiates arsenic trioxide-induced JNK activation. |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9043-8 |year= 2005 |pmid= 15637062 |doi= 10.1074/jbc.M413564200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rossi V, Levati L, Biondi A |title=Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR. |journal=Methods Mol. Med. |volume=125 |issue=  |pages= 115-26 |year= 2006 |pmid= 16502581 |doi= }}
*{{cite journal | author=Mokany E, Todd AV, Fuery CJ, Applegate TL |title=Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR. |journal=Methods Mol. Med. |volume=125 |issue=  |pages= 127-47 |year= 2006 |pmid= 16502582 |doi= }}
*{{cite journal | author=Heuer K, Sylvester M, Kliche S, ''et al.'' |title=Lipid-binding hSH3 domains in immune cell adapter proteins. |journal=J. Mol. Biol. |volume=361 |issue= 1 |pages= 94-104 |year= 2006 |pmid= 16831444 |doi= 10.1016/j.jmb.2006.06.004 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:37, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.[1][2][3]

Function

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).[3]

Interactions

PRAM1 has been shown to interact with TRIM27.[4]

References

  1. ↑ Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (Jun 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J Biol Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
  2. ↑ Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMC 533979. PMID 15572693.
  3. ↑ 3.0 3.1 "Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1".
  4. ↑ Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10): 1319–29. PMID 9570750.

Further reading

  • Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia". Oncogene. 13 (5): 971–82. PMID 8806687.
  • Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD (1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10): 1319–29. PMID 9570750.
  • Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell. 7 (6): 1233–43. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826.
  • Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR". Methods Mol. Med. 125: 115–26. doi:10.1385/1-59745-017-0:115. PMID 16502581.
  • Mokany E, Todd AV, Fuery CJ, Applegate TL (2006). "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR". Methods Mol. Med. 125: 127–47. doi:10.1385/1-59745-017-0:127. PMID 16502582.
  • Heuer K, Sylvester M, Kliche S, Pusch R, Thiemke K, Schraven B, Freund C (2006). "Lipid-binding hSH3 domains in immune cell adapter proteins". J. Mol. Biol. 361 (1): 94–104. doi:10.1016/j.jmb.2006.06.004. PMID 16831444.


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