PTTG1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Securin''' is a [[protein]] that in humans is encoded by the ''PTTG1'' [[gene]].<ref name="pmid9811450">{{cite journal | vauthors = Domínguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA | title = hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG | journal = Oncogene | volume = 17 | issue = 17 | pages = 2187–93 | date = Oct 1998 | pmid = 9811450 | pmc =  | doi = 10.1038/sj.onc.1202140 }}</ref><ref name="pmid9892021">{{cite journal | vauthors = Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S | title = Structure, expression, and function of human pituitary tumor-transforming gene (PTTG) | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 156–66 | date = Jan 1999 | pmid = 9892021 | pmc = | doi = 10.1210/me.13.1.156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pituitary tumor-transforming 1
| HGNCid = 9690
| Symbol = PTTG1
| AltSymbols =; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1
| OMIM = 604147
| ECnumber = 
| Homologene = 3110
| MGIid = 1353578
| GeneAtlas_image1 = PBB_GE_PTTG1_203554_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0051276 |text = chromosome organization and biogenesis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9232
    | Hs_Ensembl = ENSG00000164611
    | Hs_RefseqProtein = NP_004210
    | Hs_RefseqmRNA = NM_004219
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 159781418
    | Hs_GenLoc_end = 159788323
    | Hs_Uniprot = O95997
    | Mm_EntrezGene = 30939
    | Mm_Ensembl = ENSMUSG00000020415
    | Mm_RefseqmRNA = NM_013917
    | Mm_RefseqProtein = NP_038945
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 43263685
    | Mm_GenLoc_end = 43269674
    | Mm_Uniprot = Q3Y5K4
  }}
}}
'''Pituitary tumor-transforming 1''', also known as '''PTTG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.<ref name="entrez">{{cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PTTG1 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[DNAJA1]],<ref name = pmid9915854/>
{{PBB_Further_reading
* [[Ku70]]<ref name = pmid11238996>{{cite journal | vauthors = Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M | title = Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase | journal = Nucleic Acids Research | volume = 29 | issue = 6 | pages = 1300–7 | date = Mar 2001 | pmid = 11238996 | pmc = 29753 | doi =  10.1093/nar/29.6.1300}}</ref>
| citations =  
* [[P53]],<ref name = pmid12355087>{{cite journal | vauthors = Bernal JA, Luna R, Espina A, Lázaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA | title = Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis | journal = Nature Genetics | volume = 32 | issue = 2 | pages = 306–11 | date = Oct 2002 | pmid = 12355087 | doi = 10.1038/ng997 }}</ref>
*{{cite journal | author=Yu R, Melmed S |title=Pituitary tumor transforming gene: an update. |journal=Frontiers of hormone research |volume=32 |issue= |pages= 175-85 |year= 2004 |pmid= 15281346 |doi=  }}
* [[PTTG1IP]],<ref name = pmid10781616>{{cite journal | vauthors = Chien W, Pei L | title = A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 19422–7 | date = Jun 2000 | pmid = 10781616 | doi = 10.1074/jbc.M910105199 }}</ref>  and
*{{cite journal | author=Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N |title=The emerging role of pituitary tumor transforming gene in tumorigenesis. |journal=Clinical medicine & research |volume=4 |issue= 2 |pages= 130-7 |year= 2006 |pmid= 16809406 |doi= }}
* [[RPS10]].<ref name = pmid9915854>{{cite journal | vauthors = Pei L | title = Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 3151–8 | date = Jan 1999 | pmid = 9915854 | doi =  10.1074/jbc.274.5.3151}}</ref>
*{{cite journal | author=Domínguez A, Ramos-Morales F, Romero F, ''et al.'' |title=hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. |journal=Oncogene |volume=17 |issue= 17 |pages= 2187-93 |year= 1998 |pmid= 9811450 |doi= 10.1038/sj.onc.1202140 }}
 
*{{cite journal | author=Zhang X, Horwitz GA, Prezant TR, ''et al.'' |title=Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 156-66 |year= 1999 |pmid= 9892021 |doi=  }}
== Regulation ==
*{{cite journal | author=Pei L |title=Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 3151-8 |year= 1999 |pmid= 9915854 |doi= }}
 
*{{cite journal | author=Kakar SS |title=Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 93-5 |year= 1999 |pmid= 9925941 |doi= }}
During Mitosis CDK1 phosphorylate PTTG1 at Ser-165.<ref>{{cite journal | vauthors = Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M | title = Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product | journal = Oncogene | volume = 19 | issue = 3 | pages = 403–9 | date = Jan 2000 | pmid = 10656688 | doi = 10.1038/sj.onc.1203320 }}</ref>PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125.<ref>{{cite journal | vauthors = Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S | title = Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125 | journal = Biochemical Pharmacology | volume = 84 | issue = 5 | pages = 598–611 | date = Sep 2012 | pmid = 22704958 | doi = 10.1016/j.bcp.2012.06.004 }}</ref>
*{{cite journal  | author=Zhang X, Horwitz GA, Heaney AP, ''et al.'' |title=Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 761-7 |year= 1999 |pmid= 10022450 |doi= }}
 
*{{cite journal | author=Lee IA, Seong C, Choe IS |title=Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 5 |pages= 891-7 |year= 1999 |pmid= 10365261 |doi= }}
== References ==
*{{cite journal | author=Kakar SS, Jennes L |title=Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 211-6 |year= 1999 |pmid= 10393434 |doi= }}
{{reflist|33em}}
*{{cite journal | author=Zou H, McGarry TJ, Bernal T, Kirschner MW |title=Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. |journal=Science |volume=285 |issue= 5426 |pages= 418-22 |year= 1999 |pmid= 10411507 |doi= }}
 
*{{cite journal | author=Kakar SS |title=Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). |journal=Gene |volume=240 |issue= 2 |pages= 317-24 |year= 2000 |pmid= 10580151 |doi= }}
== Further reading ==
*{{cite journal | author=Ramos-Morales F, Domínguez A, Romero F, ''et al.'' |title=Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product. |journal=Oncogene |volume=19 |issue= 3 |pages= 403-9 |year= 2000 |pmid= 10656688 |doi= 10.1038/sj.onc.1203320 }}
{{refbegin|33em}}
*{{cite journal | author=Chien W, Pei L |title=A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19422-7 |year= 2000 |pmid= 10781616 |doi= 10.1074/jbc.M910105199 }}
* {{cite journal | vauthors = Yu R, Melmed S | title = Pituitary tumor transforming gene: an update | journal = Frontiers of Hormone Research | volume = 32 | issue = | pages = 175–85 | year = 2004 | pmid = 15281346 | doi = 10.1159/000079044 | series = Frontiers of Hormone Research }}
*{{cite journal | author=Ishikawa H, Heaney AP, Yu R, ''et al.'' |title=Human pituitary tumor-transforming gene induces angiogenesis. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 2 |pages= 867-74 |year= 2001 |pmid= 11158059 |doi= }}
* {{cite journal | vauthors = Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N | title = The emerging role of pituitary tumor transforming gene in tumorigenesis | journal = Clinical Medicine & Research | volume = 4 | issue = 2 | pages = 130–7 | date = Jun 2006 | pmid = 16809406 | pmc = 1483889 | doi = 10.3121/cmr.4.2.130 }}
*{{cite journal | author=Zur A, Brandeis M |title=Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. |journal=EMBO J. |volume=20 |issue= 4 |pages= 792-801 |year= 2001 |pmid= 11179223 |doi= 10.1093/emboj/20.4.792 }}
* {{cite journal | vauthors = Pei L | title = Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 3151–8 | date = Jan 1999 | pmid = 9915854 | doi = 10.1074/jbc.274.5.3151 }}
*{{cite journal | author=Romero F, Multon MC, Ramos-Morales F, ''et al.'' |title=Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. |journal=Nucleic Acids Res. |volume=29 |issue= 6 |pages= 1300-7 |year= 2001 |pmid= 11238996 |doi= }}
* {{cite journal | vauthors = Kakar SS | title = Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 83 | issue = 1–2 | pages = 93–5 | year = 1999 | pmid = 9925941 | doi = 10.1159/000015139 }}
*{{cite journal | author=Jallepalli PV, Waizenegger IC, Bunz F, ''et al.'' |title=Securin is required for chromosomal stability in human cells. |journal=Cell |volume=105 |issue= 4 |pages= 445-57 |year= 2001 |pmid= 11371342 |doi= }}
* {{cite journal | vauthors = Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S | title = Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 84 | issue = 2 | pages = 761–7 | date = Feb 1999 | pmid = 10022450 | doi = 10.1210/jc.84.2.761 }}
*{{cite journal | author=Hilioti Z, Chung YS, Mochizuki Y, ''et al.'' |title=The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. |journal=Curr. Biol. |volume=11 |issue= 17 |pages= 1347-52 |year= 2001 |pmid= 11553328 |doi= }}
* {{cite journal | vauthors = Lee IA, Seong C, Choe IS | title = Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene | journal = Biochemistry and Molecular Biology International | volume = 47 | issue = 5 | pages = 891–7 | date = May 1999 | pmid = 10365261 | doi = 10.1080/15216549900201993 }}
*{{cite journal | author=Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM |title=Regulation of human separase by securin binding and autocleavage. |journal=Curr. Biol. |volume=12 |issue= 16 |pages= 1368-78 |year= 2003 |pmid= 12194817 |doi= }}
* {{cite journal | vauthors = Kakar SS, Jennes L | title = Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3–4 | pages = 211–6 | year = 1999 | pmid = 10393434 | doi = 10.1159/000015261 }}
*{{cite journal | author=McCabe CJ, Boelaert K, Tannahill LA, ''et al.'' |title=Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 9 |pages= 4238-44 |year= 2002 |pmid= 12213878 |doi= }}
* {{cite journal | vauthors = Zou H, McGarry TJ, Bernal T, Kirschner MW | title = Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis | journal = Science | volume = 285 | issue = 5426 | pages = 418–22 | date = Jul 1999 | pmid = 10411507 | doi = 10.1126/science.285.5426.418 }}
}}
* {{cite journal | vauthors = Kakar SS | title = Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG) | journal = Gene | volume = 240 | issue = 2 | pages = 317–24 | date = Nov 1999 | pmid = 10580151 | doi = 10.1016/S0378-1119(99)00446-1 }}
* {{cite journal | vauthors = Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M | title = Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product | journal = Oncogene | volume = 19 | issue = 3 | pages = 403–9 | date = Jan 2000 | pmid = 10656688 | doi = 10.1038/sj.onc.1203320 }}
* {{cite journal | vauthors = Chien W, Pei L | title = A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 19422–7 | date = Jun 2000 | pmid = 10781616 | doi = 10.1074/jbc.M910105199 }}
* {{cite journal | vauthors = Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S | title = Human pituitary tumor-transforming gene induces angiogenesis | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 2 | pages = 867–74 | date = Feb 2001 | pmid = 11158059 | doi = 10.1210/jc.86.2.867 }}
* {{cite journal | vauthors = Zur A, Brandeis M | title = Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis | journal = The EMBO Journal | volume = 20 | issue = 4 | pages = 792–801 | date = Feb 2001 | pmid = 11179223 | pmc = 145417 | doi = 10.1093/emboj/20.4.792 }}
* {{cite journal | vauthors = Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M | title = Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase | journal = Nucleic Acids Research | volume = 29 | issue = 6 | pages = 1300–7 | date = Mar 2001 | pmid = 11238996 | pmc = 29753 | doi = 10.1093/nar/29.6.1300 }}
* {{cite journal | vauthors = Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C | title = Securin is required for chromosomal stability in human cells | journal = Cell | volume = 105 | issue = 4 | pages = 445–57 | date = May 2001 | pmid = 11371342 | doi = 10.1016/S0092-8674(01)00340-3 }}
* {{cite journal | vauthors = Hilioti Z, Chung YS, Mochizuki Y, Hardy CF, Cohen-Fix O | title = The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner | journal = Current Biology | volume = 11 | issue = 17 | pages = 1347–52 | date = Sep 2001 | pmid = 11553328 | doi = 10.1016/S0960-9822(01)00399-2 }}
* {{cite journal | vauthors = Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM | title = Regulation of human separase by securin binding and autocleavage | journal = Current Biology | volume = 12 | issue = 16 | pages = 1368–78 | date = Aug 2002 | pmid = 12194817 | doi = 10.1016/S0960-9822(02)01073-4 }}
* {{cite journal | vauthors = McCabe CJ, Boelaert K, Tannahill LA, Heaney AP, Stratford AL, Khaira JS, Hussain S, Sheppard MC, Franklyn JA, Gittoes NJ | title = Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 9 | pages = 4238–44 | date = Sep 2002 | pmid = 12213878 | doi = 10.1210/jc.2002-020309 }}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 18:59, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Securin is a protein that in humans is encoded by the PTTG1 gene.[1][2][3]

Function

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.[3]

Interactions

PTTG1 has been shown to interact with:

Regulation

During Mitosis CDK1 phosphorylate PTTG1 at Ser-165.[8]PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125.[9]

References

  1. ↑ Domínguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA (Oct 1998). "hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG". Oncogene. 17 (17): 2187–93. doi:10.1038/sj.onc.1202140. PMID 9811450.
  2. ↑ Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (Jan 1999). "Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)". Molecular Endocrinology. 13 (1): 156–66. doi:10.1210/me.13.1.156. PMID 9892021.
  3. ↑ 3.0 3.1 "Entrez Gene: PTTG1 pituitary tumor-transforming 1".
  4. ↑ 4.0 4.1 Pei L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". The Journal of Biological Chemistry. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
  5. ↑ Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001). "Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase". Nucleic Acids Research. 29 (6): 1300–7. doi:10.1093/nar/29.6.1300. PMC 29753. PMID 11238996.
  6. ↑ Bernal JA, Luna R, Espina A, Lázaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA (Oct 2002). "Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis". Nature Genetics. 32 (2): 306–11. doi:10.1038/ng997. PMID 12355087.
  7. ↑ Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". The Journal of Biological Chemistry. 275 (25): 19422–7. doi:10.1074/jbc.M910105199. PMID 10781616.
  8. ↑ Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product". Oncogene. 19 (3): 403–9. doi:10.1038/sj.onc.1203320. PMID 10656688.
  9. ↑ Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S (Sep 2012). "Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125". Biochemical Pharmacology. 84 (5): 598–611. doi:10.1016/j.bcp.2012.06.004. PMID 22704958.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=PTTG1&oldid=1420377"