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{{Infobox_gene}}
{{GNF_Protein_box
'''Ras-related protein Rab-22A''' is a [[protein]] that in humans is encoded by the ''RAB22A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB22A RAB22A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57403| accessdate = }}</ref>
| image = PBB_Protein_RAB22A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yvd.
| PDB = {{PDB2|1yvd}}, {{PDB2|1z0j}}
| Name = RAB22A, member RAS oncogene family
| HGNCid = 9764
| Symbol = RAB22A
| AltSymbols =; MGC16770
| OMIM = 
| ECnumber = 
| Homologene = 10782
| MGIid = 105072
| GeneAtlas_image1 = PBB_GE_RAB22A_218360_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB22A_213405_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007032 |text = endosome organization and biogenesis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57403
    | Hs_Ensembl = ENSG00000124209
    | Hs_RefseqProtein = NP_065724
    | Hs_RefseqmRNA = NM_020673
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 56318177
    | Hs_GenLoc_end = 56375966
    | Hs_Uniprot = Q9UL26
    | Mm_EntrezGene = 19334
    | Mm_Ensembl = ENSMUSG00000027519
    | Mm_RefseqmRNA = NM_024436
    | Mm_RefseqProtein = NP_077756
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 173302800
    | Mm_GenLoc_end = 173347611
    | Mm_Uniprot = Q0PD34
  }}
}}
'''RAB22A, member RAS oncogene family''', also known as '''RAB22A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB22A RAB22A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57403| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.<ref name="entrez">{{cite web | title = Entrez Gene: RAB22A RAB22A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57403| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the RAB family of small [[GTPases]]. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal [[antigen]] 1, and may be involved in the trafficking of and interaction between [[endosomal]] compartments.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bao S, Zhu J, Garvey WT |title=Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. |journal=Horm. Metab. Res. |volume=30 |issue= 11 |pages= 656-62 |year= 1999 |pmid= 9918381 |doi=  }}
*{{cite journal  |vauthors=Bao S, Zhu J, Garvey WT |title=Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects |journal=Horm. Metab. Res. |volume=30 |issue= 11 |pages= 656–662 |year= 1999 |pmid= 9918381 |doi=10.1055/s-2007-978953 }}
*{{cite journal  | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
*{{cite journal  | author=Bucci C |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657–662 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 |name-list-format=vanc| author2=Chiariello M  | author3=Lattero D  | display-authors=3  | last4=Maiorano  | first4=M  | last5=Bruni  | first5=C }}
*{{cite journal  | author=Opdam FJ, Kamps G, Croes H, ''et al.'' |title=Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. |journal=Eur. J. Cell Biol. |volume=79 |issue= 5 |pages= 308-16 |year= 2000 |pmid= 10887961 |doi=  }}
*{{cite journal  | author=Opdam FJ |title=Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells |journal=Eur. J. Cell Biol. |volume=79 |issue= 5 |pages= 308–316 |year= 2000 |pmid= 10887961 |doi=10.1078/S0171-9335(04)70034-5  |name-list-format=vanc| author2=Kamps G  | author3=Croes H  | display-authors=3  | last4=Van Bokhoven  | first4=H  | last5=Ginsel  | first5=LA  | last6=Fransen  | first6=JA }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–871 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Kauppi M, Simonsen A, Bremnes B, ''et al.'' |title=The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. |journal=J. Cell. Sci. |volume=115 |issue= Pt 5 |pages= 899-911 |year= 2002 |pmid= 11870209 |doi=  }}
*{{cite journal  | author=Kauppi M |title=The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking |journal=J. Cell Sci. |volume=115 |issue= Pt 5 |pages= 899–911 |year= 2002 |pmid= 11870209 |doi= |name-list-format=vanc| author2=Simonsen A  | author3=Bremnes B  | display-authors=3  | last4=Vieira  | first4=A  | last5=Callaghan  | first5=J  | last6=Stenmark  | first6=H  | last7=Olkkonen  | first7=VM }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670-9 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 }}
*{{cite journal  |vauthors=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670–4679 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Weigert R, Yeung AC, Li J, Donaldson JG |title=Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3758-70 |year= 2005 |pmid= 15181155 |doi= 10.1091/mbc.E04-04-0342 }}
*{{cite journal  |vauthors=Weigert R, Yeung AC, Li J, Donaldson JG |title=Rab22a regulates the recycling of membrane proteins internalized independently of clathrin |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3758–3770 |year= 2005 |pmid= 15181155 |doi= 10.1091/mbc.E04-04-0342 | pmc=491835 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Mesa R, Magadán J, Barbieri A, ''et al.'' |title=Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus. |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 339-53 |year= 2005 |pmid= 15748882 |doi= 10.1016/j.yexcr.2004.11.017 }}
*{{cite journal  | author=Mesa R |title=Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 339–353 |year= 2005 |pmid= 15748882 |doi= 10.1016/j.yexcr.2004.11.017 |name-list-format=vanc| author2=Magadán J  | author3=Barbieri A  | display-authors=3  | last4=López  | first4=Cecilia  | last5=Stahl  | first5=Philip D.  | last6=Mayorga  | first6=Luis S. }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–1625 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR  | author3=Ozdamar B  | display-authors=3  | last4=Bose  | first4=R  | last5=Liu  | first5=Z  | last6=Donovan  | first6=RS  | last7=Shinjo  | first7=F  | last8=Liu  | first8=Y  | last9=Dembowy  | first9=J }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Magadán JG, Barbieri MA, Mesa R, ''et al.'' |title=Rab22a regulates the sorting of transferrin to recycling endosomes. |journal=Mol. Cell. Biol. |volume=26 |issue= 7 |pages= 2595-614 |year= 2006 |pmid= 16537905 |doi= 10.1128/MCB.26.7.2595-2614.2006 }}
*{{cite journal  | author=Magadán JG |title=Rab22a regulates the sorting of transferrin to recycling endosomes |journal=Mol. Cell. Biol. |volume=26 |issue= 7 |pages= 2595–2614 |year= 2006 |pmid= 16537905 |doi= 10.1128/MCB.26.7.2595-2614.2006 | pmc=1430328  |name-list-format=vanc| author2=Barbieri MA  | author3=Mesa R  | display-authors=3  | last4=Stahl  | first4=P. D.  | last5=Mayorga  | first5=L. S. |url=http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4074&context=open_access_pubs}}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=57403}}
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Latest revision as of 07:18, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.[1]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Further reading



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