RAB6A: Difference between revisions

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{{Infobox_gene}}
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'''Ras-related protein Rab-6A''' is a [[protein]] that in humans is encoded by the ''RAB6A'' [[gene]] located in the eleventh chromosome.<ref name="entrez">{{cite web | title = Entrez Gene: RAB6A RAB6A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5870| accessdate = }}</ref> Its main function is the regulation of protein transport from the [[Golgi apparatus|Golgi complex]] to the [[endoplasmic reticulum]] and the exocytosis along with the microtubules.
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
RAB6A has been shown to [[Protein-protein interaction|interact]] with:
| image = PBB_Protein_RAB6A_image.jpg
* [[BICD1]],<ref name = pmid12401177/><ref name = pmid12447383>{{cite journal | vauthors = Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC | title = Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex | journal = Nat. Cell Biol. | volume = 4 | issue = 12 | pages = 986–92 | date = December 2002 | pmid = 12447383 | doi = 10.1038/ncb891 }}</ref>
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yzq.
* [[DCTN1]]<ref name = pmid12401177>{{cite journal | vauthors = Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA | title = The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes | journal = Curr. Biol. | volume = 12 | issue = 20 | pages = 1792–5 | date = October 2002 | pmid = 12401177 | doi = 10.1016/s0960-9822(02)01221-6}}</ref>
| PDB = {{PDB2|1yzq}}, {{PDB2|2fe4}}, {{PDB2|2ffq}}, {{PDB2|2gil}}
* [[ERC1]],<ref name = pmid11929610>{{cite journal | vauthors = Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B | title = Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport | journal = Traffic | volume = 3 | issue = 4 | pages = 289–97 | date = April 2002 | pmid = 11929610 | doi =  10.1034/j.1600-0854.2002.030406.x}}</ref>  and
| Name = RAB6A, member RAS oncogene family
* [[KIF20A]].<ref name = pmid9438855>{{cite journal | vauthors = Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B | title = Interaction of a Golgi-associated kinesin-like protein with Rab6 | journal = Science | volume = 279 | issue = 5350 | pages = 580–5 | date = January 1998 | pmid = 9438855 | doi =  10.1126/science.279.5350.580}}</ref><ref name = pmid11071909>{{cite journal | vauthors = Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA | title = Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms | journal = Mol. Biol. Cell | volume = 11 | issue = 11 | pages = 3819–33 | date = November 2000 | pmid = 11071909 | pmc = 15039 | doi = 10.1091/mbc.11.11.3819}}</ref>
| HGNCid = 9786
| Symbol = RAB6A
| AltSymbols =; RAB6; RAB6A'; RAB6B
| OMIM = 179513
| ECnumber =
| Homologene = 55697
| MGIid = 894313
| GeneAtlas_image1 = PBB_GE_RAB6A_210406_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB6A_201045_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAB6A_201047_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}  
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5870
    | Hs_Ensembl = ENSG00000175582
    | Hs_RefseqProtein = NP_002860
    | Hs_RefseqmRNA = NM_002869
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 73064342
    | Hs_GenLoc_end = 73149849
    | Hs_Uniprot = P20340
    | Mm_EntrezGene = 19346
    | Mm_Ensembl =
    | Mm_RefseqmRNA = NM_024287
    | Mm_RefseqProtein = NP_077249
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr =   
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''RAB6A, member RAS oncogene family''', also known as '''RAB6A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB6A RAB6A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5870| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
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| summary_text =
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==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R | title = Chromosome assignment of four RAS-related RAB genes. | journal = Hum. Genet. | volume = 86 | issue = 4 | pages = 350–4 | year = 1991 | pmid = 1999336 | doi = 10.1007/BF00201831 }}
| citations =
*{{cite journal | vauthors = Goud B, Zahraoui A, Tavitian A, Saraste J | title = Small GTP-binding protein associated with Golgi cisternae. | journal = Nature | volume = 345 | issue = 6275 | pages = 553–6 | year = 1990 | pmid = 2112230 | doi = 10.1038/345553a0 }}
*{{cite journal | author=Rousseau-Merck MF, Zahraoui A, Touchot N, ''et al.'' |title=Chromosome assignment of four RAS-related RAB genes. |journal=Hum. Genet. |volume=86 |issue= 4 |pages= 350-4 |year= 1991 |pmid= 1999336 |doi= }}
*{{cite journal | vauthors = Zahraoui A, Touchot N, Chardin P, Tavitian A | title = The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. | journal = J. Biol. Chem. | volume = 264 | issue = 21 | pages = 12394–401 | year = 1989 | pmid = 2501306 | doi =  }}
*{{cite journal | author=Goud B, Zahraoui A, Tavitian A, Saraste J |title=Small GTP-binding protein associated with Golgi cisternae. |journal=Nature |volume=345 |issue= 6275 |pages= 553-6 |year= 1990 |pmid= 2112230 |doi= 10.1038/345553a0 }}
*{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394-401 |year= 1989 |pmid= 2501306 |doi=  }}
*{{cite journal | vauthors = Beranger F, Cadwallader K, Porfiri E, Powers S, Evans T, de Gunzburg J, Hancock JF | title = Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase | journal = J. Biol. Chem. | volume = 269 | issue = 18 | pages = 13637–43 | year = 1994 | pmid = 8175798 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | vauthors = Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL | title = REP-2, a Rab escort protein encoded by the choroideremia-like gene | journal = J. Biol. Chem. | volume = 269 | issue = 3 | pages = 2111–7 | year = 1994 | pmid = 8294464 | doi =  }}
*{{cite journal | author=Beranger F, Cadwallader K, Porfiri E, ''et al.'' |title=Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13637-43 |year= 1994 |pmid= 8175798 |doi=  }}
*{{cite journal | vauthors = Karniguian A, Zahraoui A, Tavitian A | title = Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 16 | pages = 7647–51 | year = 1993 | pmid = 8356066 | pmc = 47199 | doi = 10.1073/pnas.90.16.7647 }}
*{{cite journal | author=Cremers FP, Armstrong SA, Seabra MC, ''et al.'' |title=REP-2, a Rab escort protein encoded by the choroideremia-like gene. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2111-7 |year= 1994 |pmid= 8294464 |doi=  }}
*{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Karniguian A, Zahraoui A, Tavitian A |title=Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7647-51 |year= 1993 |pmid= 8356066 |doi= }}
*{{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | vauthors = Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B | title = Interaction of a Golgi-associated kinesin-like protein with Rab6 | journal = Science | volume = 279 | issue = 5350 | pages = 580–5 | year = 1998 | pmid = 9438855 | doi = 10.1126/science.279.5350.580 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | vauthors = Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B | title = Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome | journal = EMBO J. | volume = 18 | issue = 7 | pages = 1772–82 | year = 1999 | pmid = 10202141 | pmc = 1171263 | doi = 10.1093/emboj/18.7.1772 }}
*{{cite journal | author=Echard A, Jollivet F, Martinez O, ''et al.'' |title=Interaction of a Golgi-associated kinesin-like protein with Rab6. |journal=Science |volume=279 |issue= 5350 |pages= 580-5 |year= 1998 |pmid= 9438855 |doi= }}
*{{cite journal | author = Barr FA | title = A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins | journal = Curr. Biol. | volume = 9 | issue = 7 | pages = 381–4 | year = 1999 | pmid = 10209123 | doi = 10.1016/S0960-9822(99)80167-5 }}
*{{cite journal | author=Cuif MH, Possmayer F, Zander H, ''et al.'' |title=Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1772-82 |year= 1999 |pmid= 10202141 |doi= 10.1093/emboj/18.7.1772 }}
*{{cite journal | vauthors = Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB | title = Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) | journal = Biochem. Biophys. Res. Commun. | volume = 258 | issue = 3 | pages = 657–62 | year = 1999 | pmid = 10329441 | doi = 10.1006/bbrc.1999.0651 }}
*{{cite journal | author=Barr FA |title=A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. |journal=Curr. Biol. |volume=9 |issue= 7 |pages= 381-4 |year= 1999 |pmid= 10209123 |doi= }}
*{{cite journal | vauthors = Caillol N, Pasqualini E, Lloubes R, Lombardo D | title = Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells | journal = J. Cell. Biochem. | volume = 79 | issue = 4 | pages = 628–47 | year = 2000 | pmid = 10996854 | doi = 10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T }}
*{{cite journal | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
*{{cite journal | vauthors = Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H | title = Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells | journal = Gene | volume = 257 | issue = 1 | pages = 67–75 | year = 2001 | pmid = 11054569 | doi = 10.1016/S0378-1119(00)00395-4 }}
*{{cite journal | author=Caillol N, Pasqualini E, Lloubes R, Lombardo D |title=Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. |journal=J. Cell. Biochem. |volume=79 |issue= 4 |pages= 628-47 |year= 2000 |pmid= 10996854 |doi= }}
*{{cite journal | vauthors = Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA | title = Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms | journal = Mol. Biol. Cell | volume = 11 | issue = 11 | pages = 3819–33 | year = 2001 | pmid = 11071909 | pmc = 15039 | doi = 10.1091/mbc.11.11.3819 }}
*{{cite journal | author=Shan J, Mason JM, Yuan L, ''et al.'' |title=Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. |journal=Gene |volume=257 |issue= 1 |pages= 67-75 |year= 2001 |pmid= 11054569 |doi= }}
*{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Echard A, Opdam FJ, de Leeuw HJ, ''et al.'' |title=Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3819-33 |year= 2001 |pmid= 11071909 |doi= }}
*{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5870}}


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Latest revision as of 08:47, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.[1] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Interactions

RAB6A has been shown to interact with:

References

  1. ↑ "Entrez Gene: RAB6A RAB6A, member RAS oncogene family".
  2. ↑ 2.0 2.1 Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177.
  3. ↑ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383.
  4. ↑ Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610.
  5. ↑ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. doi:10.1126/science.279.5350.580. PMID 9438855.
  6. ↑ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Further reading


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