RAP2B: Difference between revisions

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{{Infobox_gene}}
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'''Ras-related protein Rap-2b''' is a [[protein]] that in humans is encoded by the ''RAP2B'' [[gene]].<ref name="pmid2118648">{{cite journal | vauthors = Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG | title = RAP2B: a RAS-related GTP-binding protein from platelets | journal = Proc Natl Acad Sci U S A | volume = 87 | issue = 17 | pages = 6527–31 |date=Oct 1990 | pmid = 2118648 | pmc = 54569 | doi =10.1073/pnas.87.17.6527 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAP2B RAP2B, member of RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5912| accessdate = }}</ref> RAP2B belongs to the [[Rap GTP-binding protein|Ras-related protein]] family.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAP2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kao.
| PDB = {{PDB2|1kao}}, {{PDB2|2rap}}, {{PDB2|3rap}}
| Name = RAP2B, member of RAS oncogene family
| HGNCid = 9862
| Symbol = RAP2B
| AltSymbols =; MGC20484
| OMIM = 179541
| ECnumber =
| Homologene = 55701
| MGIid = 1921262
| GeneAtlas_image1 = PBB_GE_RAP2B_213923_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAP2B_214487_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAP2B_214488_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5912
    | Hs_Ensembl = ENSG00000181467
    | Hs_RefseqProtein = NP_002877
    | Hs_RefseqmRNA = NM_002886
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 154362719
    | Hs_GenLoc_end = 154368955
    | Hs_Uniprot = P61225
    | Mm_EntrezGene = 74012
    | Mm_Ensembl = ENSMUSG00000036894
    | Mm_RefseqmRNA = NM_028712
    | Mm_RefseqProtein = NP_082988
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 61452523
    | Mm_GenLoc_end = 61456367
    | Mm_Uniprot = Q6ZWR0
  }}
}}
'''RAP2B, member of RAS oncogene family''', also known as '''RAP2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAP2B RAP2B, member of RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5912| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.<ref name="entrez">{{cite web | title = Entrez Gene: RAP2B RAP2B, member of RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5912| accessdate = }}</ref>
| summary_text = This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Farrell FX, Ohmstede CA, Reep BR, Lapetina EG |title=cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. |journal=Nucleic Acids Res. |volume=18 |issue= 14 |pages= 4281 |year= 1990 |pmid= 2115998 |doi= }}
*{{cite journal  | vauthors=Farrell FX, Ohmstede CA, Reep BR, Lapetina EG |title=cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2 |journal=Nucleic Acids Res. |volume=18 |issue= 14 |pages= 4281 |year= 1990 |pmid= 2115998 |doi=10.1093/nar/18.14.4281  | pmc=331220 }}
*{{cite journal  | author=Ohmstede CA, Farrell FX, Reep BR, ''et al.'' |title=RAP2B: a RAS-related GTP-binding protein from platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 17 |pages= 6527-31 |year= 1990 |pmid= 2118648 |doi=  }}
*{{cite journal   |vauthors=Pizon V, Chardin P, Lerosey I, etal |title=Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region |journal=Oncogene |volume=3 |issue= 2 |pages= 201–4 |year= 1988 |pmid= 3045729 |doi=  }}
*{{cite journal | author=Pizon V, Chardin P, Lerosey I, ''et al.'' |title=Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. |journal=Oncogene |volume=3 |issue= 2 |pages= 201-4 |year= 1988 |pmid= 3045729 |doi=  }}
*{{cite journal   |vauthors=Torti M, Ramaschi G, Sinigaglia F, etal |title=Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7553–7 |year= 1993 |pmid= 8356055 |doi=10.1073/pnas.90.16.7553  | pmc=47180 }}
*{{cite journal | author=Torti M, Ramaschi G, Sinigaglia F, ''et al.'' |title=Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7553-7 |year= 1993 |pmid= 8356055 |doi=  }}
*{{cite journal   |vauthors=Mollinedo F, Perez-Sala D, Gajate C, etal |title=Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils |journal=FEBS Lett. |volume=326 |issue= 1–3 |pages= 209–14 |year= 1993 |pmid= 8391995 |doi=10.1016/0014-5793(93)81792-X }}
*{{cite journal | author=Mollinedo F, Perez-Sala D, Gajate C, ''et al.'' |title=Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils. |journal=FEBS Lett. |volume=326 |issue= 1-3 |pages= 209-14 |year= 1993 |pmid= 8391995 |doi=  }}
*{{cite journal  | vauthors=Farrell FX, Yamamoto K, Lapetina EG |title=Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated |journal=Biochem. J. |volume=289 ( Pt 2) |issue=  Pt 2|pages= 349–55 |year= 1993 |pmid= 8424780 |doi= | pmc=1132174 }}
*{{cite journal  | author=Farrell FX, Yamamoto K, Lapetina EG |title=Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. |journal=Biochem. J. |volume=289 ( Pt 2) |issue=  |pages= 349-55 |year= 1993 |pmid= 8424780 |doi=  }}
*{{cite journal   |vauthors=Nancy V, Wolthuis RM, de Tand MF, etal |title=Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8737–45 |year= 1999 |pmid= 10085114 |doi=10.1074/jbc.274.13.8737 }}
*{{cite journal | author=Nancy V, Wolthuis RM, de Tand MF, ''et al.'' |title=Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8737-45 |year= 1999 |pmid= 10085114 |doi=  }}
*{{cite journal  | vauthors=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
*{{cite journal  | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901-8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
*{{cite journal  | vauthors=Nancy V, Callebaut I, El Marjou A, de Gunzburg J |title=The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15076–84 |year= 2002 |pmid= 11786539 |doi= 10.1074/jbc.M109983200 }}
*{{cite journal  | author=Nancy V, Callebaut I, El Marjou A, de Gunzburg J |title=The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15076-84 |year= 2002 |pmid= 11786539 |doi= 10.1074/jbc.M109983200 }}
*{{cite journal   |vauthors=Evellin S, Nolte J, Tysack K, etal |title=Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16805–13 |year= 2002 |pmid= 11877431 |doi= 10.1074/jbc.M112024200 }}
*{{cite journal | author=Evellin S, Nolte J, Tysack K, ''et al.'' |title=Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16805-13 |year= 2002 |pmid= 11877431 |doi= 10.1074/jbc.M112024200 }}
*{{cite journal   |vauthors=Song C, Satoh T, Edamatsu H, etal |title=Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon |journal=Oncogene |volume=21 |issue= 53 |pages= 8105–13 |year= 2002 |pmid= 12444546 |doi= 10.1038/sj.onc.1206003 }}
*{{cite journal | author=Song C, Satoh T, Edamatsu H, ''et al.'' |title=Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. |journal=Oncogene |volume=21 |issue= 53 |pages= 8105-13 |year= 2002 |pmid= 12444546 |doi= 10.1038/sj.onc.1206003 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Greco F, Sinigaglia F, Balduini C, Torti M |title=Activation of the small GTPase Rap2B in agonist-stimulated human platelets |journal=J. Thromb. Haemost. |volume=2 |issue= 12 |pages= 2223–30 |year= 2005 |pmid= 15613030 |doi= 10.1111/j.1538-7836.2004.01018.x }}
*{{cite journal  | author=Greco F, Sinigaglia F, Balduini C, Torti M |title=Activation of the small GTPase Rap2B in agonist-stimulated human platelets. |journal=J. Thromb. Haemost. |volume=2 |issue= 12 |pages= 2223-30 |year= 2005 |pmid= 15613030 |doi= 10.1111/j.1538-7836.2004.01018.x }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Liu Y, Sun W, Zhang K, etal |title=Identification of genes differentially expressed in human primary lung squamous cell carcinoma |journal=Lung Cancer |volume=56 |issue= 3 |pages= 307–17 |year= 2007 |pmid= 17316888 |doi= 10.1016/j.lungcan.2007.01.016 }}
*{{cite journal | author=Liu Y, Sun W, Zhang K, ''et al.'' |title=Identification of genes differentially expressed in human primary lung squamous cell carcinoma. |journal=Lung Cancer |volume=56 |issue= 3 |pages= 307-17 |year= 2007 |pmid= 17316888 |doi= 10.1016/j.lungcan.2007.01.016 }}
}}
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{{refend}}
{{refend}}
{{PDB Gallery|geneid=5912}}
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Latest revision as of 08:54, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.[1][2] RAP2B belongs to the Ras-related protein family.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.[2]

References

  1. ↑ Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG (Oct 1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A. 87 (17): 6527–31. doi:10.1073/pnas.87.17.6527. PMC 54569. PMID 2118648.
  2. ↑ 2.0 2.1 "Entrez Gene: RAP2B RAP2B, member of RAS oncogene family".

Further reading



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