RASGRP3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ras guanyl-releasing protein 3''' is a [[protein]] that in humans is encoded by the ''RASGRP3'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="pmid10934204">{{cite journal | vauthors = Rebhun JF, Castro AF, Quilliam LA | title = Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 34901–8 | date = Nov 2000 | pmid = 10934204 | pmc =  | doi = 10.1074/jbc.M005327200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAS guanyl releasing protein 3 (calcium and DAG-regulated)
| HGNCid = 14545
| Symbol = RASGRP3
| AltSymbols =; GRP3; KIAA0846
| OMIM = 609531
| ECnumber = 
| Homologene = 15019
| MGIid = 3028579
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005088 |text = Ras guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017016 |text = Ras GTPase binding}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046582 |text = Rap GTPase activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25780
    | Hs_Ensembl = ENSG00000152689
    | Hs_RefseqProtein = NP_733772
    | Hs_RefseqmRNA = NM_170672
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 33514920
    | Hs_GenLoc_end = 33643162
    | Hs_Uniprot = Q8IV61
    | Mm_EntrezGene = 240168
    | Mm_Ensembl = ENSMUSG00000071042
    | Mm_RefseqmRNA = NM_207246
    | Mm_RefseqProtein = NP_997129
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 75370673
    | Mm_GenLoc_end = 75434118
    | Mm_Uniprot = 
  }}
}}
'''RAS guanyl releasing protein 3 (calcium and DAG-regulated)''', also known as '''RASGRP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RASGRP3 has been shown to [[Protein-protein interaction|interact]] with [[PRKCD]].<ref name=pmid15213298>{{cite journal | vauthors = Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM | title = PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters | journal = Molecular Pharmacology | volume = 66 | issue = 1 | pages = 76–84 | date = Jul 2004 | pmid = 15213298 | doi = 10.1124/mol.66.1.76 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
| citations =
* {{cite journal | vauthors = Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM | title = Phorbol esters modulate the Ras exchange factor RasGRP3 | journal = Cancer Research | volume = 61 | issue = 3 | pages = 943–9 | date = Feb 2001 | pmid = 11221888 | doi =  }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901-8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
* {{cite journal | vauthors = Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC | title = Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3 | journal = Blood | volume = 102 | issue = 4 | pages = 1414–20 | date = Aug 2003 | pmid = 12730099 | doi = 10.1182/blood-2002-11-3621 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM | title = PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters | journal = Molecular Pharmacology | volume = 66 | issue = 1 | pages = 76–84 | date = Jul 2004 | pmid = 15213298 | doi = 10.1124/mol.66.1.76 }}
*{{cite journal | author=Lorenzo PS, Kung JW, Bottorff DA, ''et al.'' |title=Phorbol esters modulate the Ras exchange factor RasGRP3. |journal=Cancer Res. |volume=61 |issue= 3 |pages= 943-9 |year= 2001 |pmid= 11221888 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, Kurosaki T | title = Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 47 | pages = 16612–7 | date = Nov 2004 | pmid = 15545601 | pmc = 528733 | doi = 10.1073/pnas.0407468101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL | title = A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters | journal = Molecular and Cellular Biology | volume = 24 | issue = 24 | pages = 10515–28 | date = Dec 2004 | pmid = 15572660 | pmc = 533983 | doi = 10.1128/MCB.24.24.10515-10528.2004 }}
*{{cite journal | author=Teixeira C, Stang SL, Zheng Y, ''et al.'' |title=Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. |journal=Blood |volume=102 |issue= 4 |pages= 1414-20 |year= 2003 |pmid= 12730099 |doi= 10.1182/blood-2002-11-3621 }}
* {{cite journal | vauthors = Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC | title = Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells | journal = Blood | volume = 105 | issue = 9 | pages = 3648–54 | date = May 2005 | pmid = 15657177 | doi = 10.1182/blood-2004-10-3916 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Brodie C, Steinhart R, Kazimirsky G, ''et al.'' |title=PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. |journal=Mol. Pharmacol. |volume=66 |issue= 1 |pages= 76-84 |year= 2004 |pmid= 15213298 |doi= 10.1124/mol.66.1.76 }}
* {{cite journal | vauthors = Okamura SM, Oki-Idouchi CE, Lorenzo PS | title = The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain | journal = The Journal of Biological Chemistry | volume = 281 | issue = 47 | pages = 36132–9 | date = Nov 2006 | pmid = 17012239 | doi = 10.1074/jbc.M605093200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL | title = The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration | journal = Circulation Research | volume = 108 | issue = 10 | pages = 1199–208 | date = May 2011 | pmid = 21474816 | doi = 10.1161/CIRCRESAHA.110.230888 | pmc = 3709466 }}
*{{cite journal | author=Aiba Y, Oh-hora M, Kiyonaka S, ''et al.'' |title=Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 47 |pages= 16612-7 |year= 2004 |pmid= 15545601 |doi= 10.1073/pnas.0407468101 }}
*{{cite journal | author=Roberts DM, Anderson AL, Hidaka M, ''et al.'' |title=A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10515-28 |year= 2004 |pmid= 15572660 |doi= 10.1128/MCB.24.24.10515-10528.2004 }}
*{{cite journal | author=Zheng Y, Liu H, Coughlin J, ''et al.'' |title=Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. |journal=Blood |volume=105 |issue= 9 |pages= 3648-54 |year= 2005 |pmid= 15657177 |doi= 10.1182/blood-2004-10-3916 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Okamura SM, Oki-Idouchi CE, Lorenzo PS |title=The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain. |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36132-9 |year= 2007 |pmid= 17012239 |doi= 10.1074/jbc.M605093200 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-2-stub}}
{{WikiDoc Sources}}
 
[[Category:EF-hand-containing proteins]]

Latest revision as of 08:48, 16 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[1][2][3]

Function

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[3]

Interactions

RASGRP3 has been shown to interact with PRKCD.[4]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  2. ↑ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
  3. ↑ 3.0 3.1 "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".
  4. ↑ Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=RASGRP3&oldid=1531833"