RENBP: Difference between revisions

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{{Infobox_gene}}
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'''N-acylglucosamine 2-epimerase''' is an [[enzyme]] that in humans is encoded by the ''RENBP'' [[gene]].<ref name="pmid1618798">{{cite journal | vauthors = Takahashi S, Inoue H, Miyake Y | title = The human gene for renin-binding protein | journal = J Biol Chem | volume = 267 | issue = 18 | pages = 13007–13 |date=Aug 1992 | pmid = 1618798 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RENBP renin binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5973| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Renin binding protein
| HGNCid = 9959
| Symbol = RENBP
| AltSymbols =; RBP; RNBP
| OMIM = 312420
| ECnumber =
| Homologene = 2184
| MGIid = 105940
  | GeneAtlas_image1 = PBB_GE_RENBP_206617_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004476 |text = mannose-6-phosphate isomerase activity}} {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0050121 |text = N-acylglucosamine 2-epimerase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006013 |text = mannose metabolic process}} {{GNF_GO|id=GO:0006044 |text = N-acetylglucosamine metabolic process}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5973
    | Hs_Ensembl = ENSG00000102032
    | Hs_RefseqProtein = NP_002901
    | Hs_RefseqmRNA = NM_002910
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152853917
    | Hs_GenLoc_end = 152863426
    | Hs_Uniprot = P51606
    | Mm_EntrezGene = 19703
    | Mm_Ensembl = ENSMUSG00000031387
    | Mm_RefseqmRNA = NM_023132
    | Mm_RefseqProtein = NP_075621
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70174842
    | Mm_GenLoc_end = 70183538
    | Mm_Uniprot = Q3TIZ6
  }}
}}
'''Renin binding protein''', also known as '''RENBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RENBP renin binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5973| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.<ref name="entrez">{{cite web | title = Entrez Gene: RENBP renin binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5973| accessdate = }}</ref>
| summary_text = The gene product inhibits renin activity by forming a dimer with [[renin]], a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of [[N-acetylglucosamine]] to [[N-acetylmannosamine]], indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Takahashi S, Inoue H, Miyake Y |title=The human gene for renin-binding protein. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 13007-13 |year= 1992 |pmid= 1618798 |doi=  }}
*{{cite journal  | vauthors=Inoue H, Takahashi S, Fukui K, Miyake Y |title=Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif |journal=J. Biochem. |volume=110 |issue= 4 |pages= 493–500 |year= 1992 |pmid= 1723410 |doi=  }}
*{{cite journal  | author=Inoue H, Takahashi S, Fukui K, Miyake Y |title=Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif. |journal=J. Biochem. |volume=110 |issue= 4 |pages= 493-500 |year= 1992 |pmid= 1723410 |doi=  }}
*{{cite journal  | vauthors=Takahashi S, Miura R, Miyake Y |title=A study on renin binding protein (RnBP) in the human kidney |journal=J. Biochem. |volume=97 |issue= 2 |pages= 671–7 |year= 1985 |pmid= 3924907 |doi=  }}
*{{cite journal | author=Takahashi S, Miura R, Miyake Y |title=A study on renin binding protein (RnBP) in the human kidney. |journal=J. Biochem. |volume=97 |issue= 2 |pages= 671-7 |year= 1985 |pmid= 3924907 |doi=  }}
*{{cite journal   |vauthors=Murakami K, Hirose S, Chino S, etal |title=Properties of renin-binding protein |journal=Clinical and experimental hypertension. Part A, Theory and practice |volume=4 |issue= 11–12 |pages= 2073–81 |year= 1983 |pmid= 6756682 |doi=10.3109/10641968209062372 }}
*{{cite journal  | author=Murakami K, Hirose S, Chino S, ''et al.'' |title=Properties of renin-binding protein. |journal=Clinical and experimental hypertension.  Part A, Theory and practice |volume=4 |issue= 11-12 |pages= 2073-81 |year= 1983 |pmid= 6756682 |doi= }}
*{{cite journal  | vauthors=Faranda S, Frattini A, Vezzoni P |title=The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction |journal=Gene |volume=155 |issue= 2 |pages= 237–9 |year= 1995 |pmid= 7721097 |doi=10.1016/0378-1119(94)00810-F  }}
*{{cite journal | author=Faranda S, Frattini A, Vezzoni P |title=The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction. |journal=Gene |volume=155 |issue= 2 |pages= 237-9 |year= 1995 |pmid= 7721097 |doi= }}
*{{cite journal   |vauthors=van den Ouweland AM, Verdijk M, Kiochis P, etal |title=The human renin-binding protein gene (RENBP) maps in Xq28 |journal=Genomics |volume=21 |issue= 1 |pages= 279–81 |year= 1994 |pmid= 8088804 |doi= 10.1006/geno.1994.1259 }}
*{{cite journal | author=van den Ouweland AM, Verdijk M, Kiochis P, ''et al.'' |title=The human renin-binding protein gene (RENBP) maps in Xq28. |journal=Genomics |volume=21 |issue= 1 |pages= 279-81 |year= 1994 |pmid= 8088804 |doi= 10.1006/geno.1994.1259 }}
*{{cite journal   |vauthors=Knöll A, Schunkert H, Reichwald K, etal |title=Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males |journal=Hum. Mol. Genet. |volume=6 |issue= 9 |pages= 1527–34 |year= 1998 |pmid= 9285790 |doi=10.1093/hmg/6.9.1527  }}
*{{cite journal  | author=Knöll A, Schunkert H, Reichwald K, ''et al.'' |title=Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males. |journal=Hum. Mol. Genet. |volume=6 |issue= 9 |pages= 1527-34 |year= 1998 |pmid= 9285790 |doi= }}
*{{cite journal  | vauthors=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse |journal=Genomics |volume=44 |issue= 1 |pages= 8–14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
*{{cite journal | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8-14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
*{{cite journal   |vauthors=Stäsche R, Hinderlich S, Weise C, etal |title=A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24319–24 |year= 1997 |pmid= 9305888 |doi=10.1074/jbc.272.39.24319  }}
*{{cite journal | author=Stäsche R, Hinderlich S, Weise C, ''et al.'' |title=A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24319-24 |year= 1997 |pmid= 9305888 |doi=  }}
*{{cite journal   |vauthors=Takahashi S, Takahashi K, Kaneko T, etal |title=Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase |journal=J. Biochem. |volume=125 |issue= 2 |pages= 348–53 |year= 1999 |pmid= 9990133 |doi=  10.1093/oxfordjournals.jbchem.a022293}}
*{{cite journal | author=Takahashi S, Takahashi K, Kaneko T, ''et al.'' |title=Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase. |journal=J. Biochem. |volume=125 |issue= 2 |pages= 348-53 |year= 1999 |pmid= 9990133 |doi=  }}
*{{cite journal   |vauthors=Takahashi S, Kumagai M, Shindo S, etal |title=Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein) |journal=J. Biochem. |volume=128 |issue= 6 |pages= 951–6 |year= 2001 |pmid= 11098137 |doi=  10.1093/oxfordjournals.jbchem.a022846}}
*{{cite journal | author=Takahashi S, Kumagai M, Shindo S, ''et al.'' |title=Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein). |journal=J. Biochem. |volume=128 |issue= 6 |pages= 951-6 |year= 2001 |pmid= 11098137 |doi=  }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Lapteva N, Nieda M, Ando Y, etal |title=Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 4 |pages= 1059–65 |year= 2001 |pmid= 11467860 |doi= 10.1006/bbrc.2001.5215 }}
*{{cite journal | author=Lapteva N, Nieda M, Ando Y, ''et al.'' |title=Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 4 |pages= 1059-65 |year= 2001 |pmid= 11467860 |doi= 10.1006/bbrc.2001.5215 }}
*{{cite journal   |vauthors=Takahashi S, Ogasawara H, Takahashi K, etal |title=Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein) |journal=J. Biochem. |volume=131 |issue= 4 |pages= 605–10 |year= 2002 |pmid= 11926999 |doi= 10.1093/oxfordjournals.jbchem.a003140}}
*{{cite journal | author=Takahashi S, Ogasawara H, Takahashi K, ''et al.'' |title=Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein). |journal=J. Biochem. |volume=131 |issue= 4 |pages= 605-10 |year= 2002 |pmid= 11926999 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR |title=GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8035–42 |year= 2003 |pmid= 12499362 |doi= 10.1074/jbc.M212127200 }}
*{{cite journal | author=Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR |title=GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8035-42 |year= 2003 |pmid= 12499362 |doi= 10.1074/jbc.M212127200 }}
*{{cite journal   |vauthors=Bohlmeyer T, Ferdensi A, Bristow MR, etal |title=Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes |journal=J. Card. Fail. |volume=9 |issue= 1 |pages= 59–68 |year= 2003 |pmid= 12612874 |doi= 10.1054/jcaf.2003.6 }}
*{{cite journal | author=Bohlmeyer T, Ferdensi A, Bristow MR, ''et al.'' |title=Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes. |journal=J. Card. Fail. |volume=9 |issue= 1 |pages= 59-68 |year= 2003 |pmid= 12612874 |doi= 10.1054/jcaf.2003.6 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:05, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.[1][2]

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.[2]

References

  1. ↑ Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem. 267 (18): 13007–13. PMID 1618798.
  2. ↑ 2.0 2.1 "Entrez Gene: RENBP renin binding protein".

Further reading



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