RFC4: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Replication factor C subunit 4''' is a [[protein]] that in humans is encoded by the ''RFC4'' [[gene]].<ref name="pmid7774928">{{cite journal | vauthors = Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K | title = Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23 | journal = Genomics | volume = 25 | issue = 1 | pages = 274–8 | date = Jan 1995 | pmid = 7774928 | pmc =  | doi = 10.1016/0888-7543(95)80135-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5984| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Replication factor C (activator 1) 4, 37kDa
| HGNCid = 9972
| Symbol = RFC4
| AltSymbols =; A1; MGC27291; RFC37
| OMIM = 102577
| ECnumber = 
| Homologene = 6288
| MGIid = 2146571
| GeneAtlas_image1 = PBB_GE_RFC4_204023_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005663 |text = DNA replication factor C complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006271 |text = DNA strand elongation during DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5984
    | Hs_Ensembl = ENSG00000163918
    | Hs_RefseqProtein = NP_002907
    | Hs_RefseqmRNA = NM_002916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 187990378
    | Hs_GenLoc_end = 188006984
    | Hs_Uniprot = P35249
    | Mm_EntrezGene = 106344
    | Mm_Ensembl = ENSMUSG00000022881
    | Mm_RefseqmRNA = NM_145480
    | Mm_RefseqProtein = NP_663455
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 23029267
    | Mm_GenLoc_end = 23043064
    | Mm_Uniprot = Q3UI84
  }}
}}
'''Replication factor C (activator 1) 4, 37kDa''', also known as '''RFC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5984| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5984| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RFC4 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[BRD4]],<ref name = pmid12192049>{{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi =  10.1128/mcb.22.18.6509-6520.2002}}</ref>
{{PBB_Further_reading
* [[CHTF18]],<ref name = pmid12930902>{{cite journal | vauthors = Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J | title = The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10237–42 | date = Sep 2003 | pmid = 12930902 | pmc = 193545 | doi = 10.1073/pnas.1434308100 }}</ref>
| citations =
* [[PCNA]],<ref name = pmid9228079/><ref name = pmid12171929>{{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}</ref>
*{{cite journal  | author=Chen M, Pan ZQ, Hurwitz J |title=Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5211-5 |year= 1992 |pmid= 1351677 |doi=  }}
* [[RFC2]],<ref name = pmid9228079>{{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi =  10.1074/jbc.272.30.18974}}</ref><ref name = pmid9751713>{{cite journal | vauthors = Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J | title = ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11607–12 | date = Sep 1998 | pmid = 9751713 | pmc = 21688 | doi =  10.1073/pnas.95.20.11607}}</ref>
*{{cite journal | author=Okumura K, Nogami M, Taguchi H, ''et al.'' |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274-8 |year= 1995 |pmid= 7774928 |doi= }}
* [[RFC3]],<ref name = pmid9488738>{{cite journal | vauthors = Ellison V, Stillman B | title = Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5979–87 | date = Mar 1998 | pmid = 9488738 | doi =  10.1074/jbc.273.10.5979}}</ref><ref name = pmid8692848>{{cite journal | vauthors = Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J | title = In vitro reconstitution of human replication factor C from its five subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6521–6 | date = Jun 1996 | pmid = 8692848 | pmc = 39056 | doi =  10.1073/pnas.93.13.6521}}</ref>  and
*{{cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, ''et al.'' |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521-6 |year= 1996 |pmid= 8692848 |doi= }}
* [[RFC5]].<ref name = pmid9228079/><ref name = pmid9751713/><ref name = pmid9488738/><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi=  }}
{{clear}}
*{{cite journal | author=Cai J, Gibbs E, Uhlmann F, ''et al.'' |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974-81 |year= 1997 |pmid= 9228079 |doi=  }}
== References ==
*{{cite journal | author=Loor G, Zhang SJ, Zhang P, ''et al.'' |title=Identification of DNA replication and cell cycle proteins that interact with PCNA. |journal=Nucleic Acids Res. |volume=25 |issue= 24 |pages= 5041-6 |year= 1998 |pmid= 9396813 |doi=  }}
{{reflist|33em}}
*{{cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979-87 |year= 1998 |pmid= 9488738 |doi=  }}
 
*{{cite journal | author=Zhang G, Gibbs E, Kelman Z, ''et al.'' |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869-74 |year= 1999 |pmid= 10051561 |doi= }}
== Further reading ==
*{{cite journal  | author=Uchiumi F, Watanabe M, Tanuma S |title=Characterization of telomere-binding activity of replication factor C large subunit p140. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 2 |pages= 482-9 |year= 1999 |pmid= 10329413 |doi=  }}
{{refbegin|33em}}
*{{cite journal | author=van der Kuip H, Carius B, Haque SJ, ''et al.'' |title=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins. |journal=J. Mol. Med. |volume=77 |issue= 4 |pages= 386-92 |year= 1999 |pmid= 10353443 |doi= }}
* {{cite journal | vauthors = Chen M, Pan ZQ, Hurwitz J | title = Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 12 | pages = 5211–5 | date = Jun 1992 | pmid = 1351677 | pmc = 49261 | doi = 10.1073/pnas.89.12.5211 }}
*{{cite journal | author=Chaib H, Cockrell EK, Rubin MA, Macoska JA |title=Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis. |journal=Neoplasia |volume=3 |issue= 1 |pages= 43-52 |year= 2001 |pmid= 11326315 |doi= 10.1038/sj/neo/7900126 }}
* {{cite journal | vauthors = Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J | title = In vitro reconstitution of human replication factor C from its five subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6521–6 | date = Jun 1996 | pmid = 8692848 | pmc = 39056 | doi = 10.1073/pnas.93.13.6521 }}
*{{cite journal | author=Naiki T, Kondo T, Nakada D, ''et al.'' |title=Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 5838-45 |year= 2001 |pmid= 11486023 |doi=  }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 1817–23 | date = Apr 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
*{{cite journal | author=Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A |title=Purification and characterization of human DNA damage checkpoint Rad complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 11236-41 |year= 2001 |pmid= 11572977 |doi= 10.1073/pnas.201373498 }}
* {{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi = 10.1074/jbc.272.30.18974 }}
*{{cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233-6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200 }}
* {{cite journal | vauthors = Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY | title = Identification of DNA replication and cell cycle proteins that interact with PCNA | journal = Nucleic Acids Research | volume = 25 | issue = 24 | pages = 5041–6 | date = Dec 1997 | pmid = 9396813 | pmc = 147130 | doi = 10.1093/nar/25.24.5041 }}
*{{cite journal | author=Anderson LA, Perkins ND |title=The large subunit of replication factor C interacts with the histone deacetylase, HDAC1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29550-4 |year= 2002 |pmid= 12045192 |doi= 10.1074/jbc.M200513200 }}
* {{cite journal | vauthors = Ellison V, Stillman B | title = Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5979–87 | date = Mar 1998 | pmid = 9488738 | doi = 10.1074/jbc.273.10.5979 }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
* {{cite journal | vauthors = Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J | title = Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 1869–74 | date = Mar 1999 | pmid = 10051561 | pmc = 26703 | doi = 10.1073/pnas.96.5.1869 }}
*{{cite journal | author=Maruyama T, Farina A, Dey A, ''et al.'' |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509-20 |year= 2002 |pmid= 12192049 |doi= }}
* {{cite journal | vauthors = Uchiumi F, Watanabe M, Tanuma S | title = Characterization of telomere-binding activity of replication factor C large subunit p140 | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 2 | pages = 482–9 | date = May 1999 | pmid = 10329413 | doi = 10.1006/bbrc.1999.0589 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T | title = The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins | journal = Journal of Molecular Medicine | volume = 77 | issue = 4 | pages = 386–92 | date = Apr 1999 | pmid = 10353443 | doi = 10.1007/s001090050365 }}
*{{cite journal | author=Anderson LA, Perkins ND |title=Regulation of RelA (p65) function by the large subunit of replication factor C. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 721-32 |year= 2003 |pmid= 12509469 |doi=  }}
* {{cite journal | vauthors = Chaib H, Cockrell EK, Rubin MA, Macoska JA | title = Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis | journal = Neoplasia | volume = 3 | issue = 1 | pages = 43–52 | year = 2001 | pmid = 11326315 | pmc = 1505021 | doi =  10.1038/sj.neo.7900126}}
*{{cite journal | author=Nagata T, Takahashi Y, Ishii Y, ''et al.'' |title=Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 713-21 |year= 2004 |pmid= 12736711 |doi=  }}
* {{cite journal | vauthors = Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K | title = Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 5838–45 | date = Sep 2001 | pmid = 11486023 | pmc = 87303 | doi = 10.1128/MCB.21.17.5838-5845.2001 }}
}}
* {{cite journal | vauthors = Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A | title = Purification and characterization of human DNA damage checkpoint Rad complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 20 | pages = 11236–41 | date = Sep 2001 | pmid = 11572977 | pmc = 58713 | doi = 10.1073/pnas.201373498 }}
* {{cite journal | vauthors = Griffith JD, Lindsey-Boltz LA, Sancar A | title = Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15233–6 | date = May 2002 | pmid = 11907025 | doi = 10.1074/jbc.C200129200 }}
* {{cite journal | vauthors = Anderson LA, Perkins ND | title = The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29550–4 | date = Aug 2002 | pmid = 12045192 | doi = 10.1074/jbc.M200513200 }}
* {{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
* {{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi = 10.1128/MCB.22.18.6509-6520.2002 }}
* {{cite journal | vauthors = Anderson LA, Perkins ND | title = Regulation of RelA (p65) function by the large subunit of replication factor C | journal = Molecular and Cellular Biology | volume = 23 | issue = 2 | pages = 721–32 | date = Jan 2003 | pmid = 12509469 | pmc = 151544 | doi = 10.1128/MCB.23.2.721-732.2003 }}
* {{cite journal | vauthors = Nagata T, Takahashi Y, Ishii Y, Asai S, Sugahara M, Nishida Y, Murata A, Chin M, Schichino H, Koshinaga T, Fukuzawa M, Mugishima H | title = Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array | journal = International Journal of Molecular Medicine | volume = 11 | issue = 6 | pages = 713–21 | date = Jun 2003 | pmid = 12736711 | doi = 10.3892/ijmm.11.6.713 }}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 16:12, 16 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.[1][2]

Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.[2]

Interactions

RFC4 has been shown to interact with:

References

  1. ↑ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
  2. ↑ 2.0 2.1 "Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa".
  3. ↑ Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Molecular and Cellular Biology. 22 (18): 6509–20. doi:10.1128/mcb.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
  4. ↑ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  5. ↑ 5.0 5.1 5.2 Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". The Journal of Biological Chemistry. 272 (30): 18974–81. doi:10.1074/jbc.272.30.18974. PMID 9228079.
  6. ↑ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  7. ↑ 7.0 7.1 Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11607–12. doi:10.1073/pnas.95.20.11607. PMC 21688. PMID 9751713.
  8. ↑ 8.0 8.1 Ellison V, Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". The Journal of Biological Chemistry. 273 (10): 5979–87. doi:10.1074/jbc.273.10.5979. PMID 9488738.
  9. ↑ Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). "In vitro reconstitution of human replication factor C from its five subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6521–6. doi:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
  10. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

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