RHOBTB1: Difference between revisions

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{{Infobox_gene}}
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'''Rho-related BTB domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''RHOBTB1'' [[gene]].<ref name="pmid11222756">{{cite journal | vauthors = Rivero F, Dislich H, Glockner G, Noegel AA | title = The Dictyostelium discoideum family of Rho-related proteins | journal = Nucleic Acids Res | volume = 29 | issue = 5 | pages = 1068–79 |date=Mar 2001 | pmid = 11222756 | pmc = 29714 | doi =10.1093/nar/29.5.1068 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9886| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Rho-related BTB domain containing 1
| HGNCid = 18738
| Symbol = RHOBTB1
| AltSymbols =; KIAA0740; MGC33059; MGC33841
| OMIM = 607351
| ECnumber = 
| Homologene = 8892
| MGIid = 1916538
| GeneAtlas_image1 = PBB_GE_RHOBTB1_212651_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9886
    | Hs_Ensembl = ENSG00000072422
    | Hs_RefseqProtein = NP_001027552
    | Hs_RefseqmRNA = NM_001032380
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 62299202
    | Hs_GenLoc_end = 62431204
    | Hs_Uniprot = O94844
    | Mm_EntrezGene = 69288
    | Mm_Ensembl = ENSMUSG00000019944
    | Mm_RefseqmRNA = XM_125637
    | Mm_RefseqProtein = XP_125637
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 68603909
    | Mm_GenLoc_end = 68685337
    | Mm_Uniprot = Q499C9
  }}
}}
'''Rho-related BTB domain containing 1''', also known as '''RHOBTB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9886| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9886| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the Rho family of the [[Ras superfamily]] of small GTPases. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9886| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277 }}
*{{cite journal  | author=Rivero F, Dislich H, Glöckner G, Noegel AA |title=The Dictyostelium discoideum family of Rho-related proteins. |journal=Nucleic Acids Res. |volume=29 |issue= 5 |pages= 1068-79 |year= 2001 |pmid= 11222756 |doi= }}
*{{cite journal  | vauthors=Ramos S, Khademi F, Somesh BP, Rivero F |title=Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. |journal=Gene |volume=298 |issue= 2 |pages= 147–57 |year= 2003 |pmid= 12426103 |doi=10.1016/S0378-1119(02)00980-0 }}
*{{cite journal  | author=Ramos S, Khademi F, Somesh BP, Rivero F |title=Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. |journal=Gene |volume=298 |issue= 2 |pages= 147-57 |year= 2003 |pmid= 12426103 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Aspenström P, Fransson A, Saras J |title=Rho GTPases have diverse effects on the organization of the actin filament system. |journal=Biochem. J. |volume=377 |issue= Pt 2 |pages= 327–37 |year= 2004 |pmid= 14521508 |doi= 10.1042/BJ20031041 | pmc=1223866 }}
*{{cite journal  | author=Aspenström P, Fransson A, Saras J |title=Rho GTPases have diverse effects on the organization of the actin filament system. |journal=Biochem. J. |volume=377 |issue= Pt 2 |pages= 327-37 |year= 2004 |pmid= 14521508 |doi= 10.1042/BJ20031041 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beder LB, Gunduz M, Ouchida M, etal |title=Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=132 |issue= 1 |pages= 19–27 |year= 2006 |pmid= 16170569 |doi= 10.1007/s00432-005-0033-0 }}
*{{cite journal | author=Beder LB, Gunduz M, Ouchida M, ''et al.'' |title=Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=132 |issue= 1 |pages= 19-27 |year= 2006 |pmid= 16170569 |doi= 10.1007/s00432-005-0033-0 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 09:11, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.[1][2]

The protein encoded by this gene belongs to the Rho family of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.[2]

References

  1. ↑ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
  2. ↑ 2.0 2.1 "Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1".

Further reading



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