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{{Infobox_gene}}
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'''Rho-related BTB domain-containing protein 2''' is a [[protein]] that in humans is encoded by the ''RHOBTB2'' [[gene]].<ref name="pmid11222756">{{cite journal | vauthors = Rivero F, Dislich H, Glockner G, Noegel AA | title = The Dictyostelium discoideum family of Rho-related proteins | journal = Nucleic Acids Res | volume = 29 | issue = 5 | pages = 1068–79 |date=Mar 2001 | pmid = 11222756 | pmc = 29714 | doi =10.1093/nar/29.5.1068 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23221| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Rho-related BTB domain containing 2
| HGNCid = 18756
| Symbol = RHOBTB2
| AltSymbols =; DBC2; KIAA0717
| OMIM = 607352
| ECnumber = 
| Homologene = 22873
| MGIid = 2180557
| GeneAtlas_image1 = PBB_GE_RHOBTB2_209441_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23221
    | Hs_Ensembl = ENSG00000008853
    | Hs_RefseqProtein = NP_055993
    | Hs_RefseqmRNA = NM_015178
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 22900875
    | Hs_GenLoc_end = 22933657
    | Hs_Uniprot = Q9BYZ6
    | Mm_EntrezGene = 246710
    | Mm_Ensembl = ENSMUSG00000022075
    | Mm_RefseqmRNA = NM_153514
    | Mm_RefseqProtein = NP_705734
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 68520072
    | Mm_GenLoc_end = 68540550
    | Mm_Uniprot = Q80TT6
  }}
}}
'''Rho-related BTB domain containing 2''', also known as '''RHOBTB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23221| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = RHOBTB2 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23221| accessdate = }}</ref>
| summary_text = RHOBTB2 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23221| accessdate = }}</ref>
}}
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277 }}
*{{cite journal  | author=Rivero F, Dislich H, Glöckner G, Noegel AA |title=The Dictyostelium discoideum family of Rho-related proteins. |journal=Nucleic Acids Res. |volume=29 |issue= 5 |pages= 1068-79 |year= 2001 |pmid= 11222756 |doi= }}
*{{cite journal   |vauthors=Hamaguchi M, Meth JL, von Klitzing C, etal |title=DBC2, a candidate for a tumor suppressor gene involved in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13647–52 |year= 2002 |pmid= 12370419 |doi= 10.1073/pnas.212516099 | pmc=129730 }}
*{{cite journal | author=Hamaguchi M, Meth JL, von Klitzing C, ''et al.'' |title=DBC2, a candidate for a tumor suppressor gene involved in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13647-52 |year= 2002 |pmid= 12370419 |doi= 10.1073/pnas.212516099 }}
*{{cite journal  | vauthors=Ramos S, Khademi F, Somesh BP, Rivero F |title=Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. |journal=Gene |volume=298 |issue= 2 |pages= 147–57 |year= 2003 |pmid= 12426103 |doi=10.1016/S0378-1119(02)00980-0 }}
*{{cite journal  | author=Ramos S, Khademi F, Somesh BP, Rivero F |title=Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. |journal=Gene |volume=298 |issue= 2 |pages= 147-57 |year= 2003 |pmid= 12426103 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Siripurapu V, Meth J, Kobayashi N, Hamaguchi M |title=DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. |journal=J. Mol. Biol. |volume=346 |issue= 1 |pages= 83–9 |year= 2005 |pmid= 15663929 |doi= 10.1016/j.jmb.2004.11.043 }}
*{{cite journal  | author=Siripurapu V, Meth J, Kobayashi N, Hamaguchi M |title=DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. |journal=J. Mol. Biol. |volume=346 |issue= 1 |pages= 83-9 |year= 2005 |pmid= 15663929 |doi= 10.1016/j.jmb.2004.11.043 }}
*{{cite journal   |vauthors=Chang FK, Sato N, Kobayashi-Simorowski N, etal |title=DBC2 is essential for transporting vesicular stomatitis virus glycoprotein. |journal=J. Mol. Biol. |volume=364 |issue= 3 |pages= 302–8 |year= 2007 |pmid= 17023000 |doi= 10.1016/j.jmb.2006.09.026 | pmc=1713265 }}
*{{cite journal | author=Chang FK, Sato N, Kobayashi-Simorowski N, ''et al.'' |title=DBC2 is essential for transporting vesicular stomatitis virus glycoprotein. |journal=J. Mol. Biol. |volume=364 |issue= 3 |pages= 302-8 |year= 2007 |pmid= 17023000 |doi= 10.1016/j.jmb.2006.09.026 }}
*{{cite journal  | vauthors=Yoshihara T, Collado D, Hamaguchi M |title=Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 4 |pages= 1076–9 |year= 2007 |pmid= 17517369 |doi= 10.1016/j.bbrc.2007.05.037 | pmc=1934618 }}
*{{cite journal  | author=Yoshihara T, Collado D, Hamaguchi M |title=Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 4 |pages= 1076-9 |year= 2007 |pmid= 17517369 |doi= 10.1016/j.bbrc.2007.05.037 }}
*{{cite journal  | vauthors=Collado D, Yoshihara T, Hamaguchi M |title=DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 3 |pages= 600–3 |year= 2007 |pmid= 17617377 |doi= 10.1016/j.bbrc.2007.06.127 | pmc=1986727 }}
*{{cite journal  | author=Collado D, Yoshihara T, Hamaguchi M |title=DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 3 |pages= 600-3 |year= 2007 |pmid= 17617377 |doi= 10.1016/j.bbrc.2007.06.127 }}
*{{cite journal   |vauthors=Ohadi M, Totonchi M, Maguire P, etal |title=Mutation analysis of the DBC2 gene in sporadic and familial breast cancer. |journal=Acta oncologica (Stockholm, Sweden) |volume=46 |issue= 6 |pages= 770–2 |year= 2007 |pmid= 17653899 |doi= 10.1080/02841860601047752 }}
*{{cite journal | author=Ohadi M, Totonchi M, Maguire P, ''et al.'' |title=Mutation analysis of the DBC2 gene in sporadic and familial breast cancer. |journal=Acta oncologica (Stockholm, Sweden) |volume=46 |issue= 6 |pages= 770-2 |year= 2007 |pmid= 17653899 |doi= 10.1080/02841860601047752 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 08:45, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene.[1][2]

RHOBTB2 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM][2]

References

  1. ↑ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
  2. ↑ 2.0 2.1 "Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2".

Further reading



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