RIN1: Difference between revisions

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{{Infobox_gene}}
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'''Ras and Rab interactor 1''' is a [[protein]] that in humans is encoded by the ''RIN1'' [[gene]].<ref name="pmid9144171">{{cite journal |vauthors=Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J | title = Protein binding and signaling properties of RIN1 suggest a unique effector function | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 10 | pages = 4954–9 |date=Jun 1997 | pmid = 9144171 | pmc = 24612 | doi =10.1073/pnas.94.10.4954  | bibcode =1997PNAS...94.4954H }}</ref><ref name="pmid1849280">{{cite journal |vauthors=Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M | title = Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 7 | pages = 2913–7 |date=May 1991 | pmid = 1849280 | pmc = 51350 | doi =10.1073/pnas.88.7.2913 | bibcode =1991PNAS...88.2913C }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIN1 Ras and Rab interactor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9610| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Ras and Rab interactor 1
| HGNCid = 18749
| Symbol = RIN1
| AltSymbols =;
| OMIM = 605965
| ECnumber = 
| Homologene = 3170
| MGIid = 2385695
| GeneAtlas_image1 = PBB_GE_RIN1_205211_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9610
    | Hs_Ensembl = ENSG00000174791
    | Hs_RefseqProtein = NP_004283
    | Hs_RefseqmRNA = NM_004292
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65856118
    | Hs_GenLoc_end = 65860576
    | Hs_Uniprot = Q13671
    | Mm_EntrezGene = 225870
    | Mm_Ensembl = ENSMUSG00000024883
    | Mm_RefseqmRNA = NM_145495
    | Mm_RefseqProtein = NP_663470
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5050808
    | Mm_GenLoc_end = 5057095
    | Mm_Uniprot = Q921Q7
  }}
}}
'''Ras and Rab interactor 1''', also known as '''RIN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIN1 Ras and Rab interactor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9610| accessdate = }}</ref>
 
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==Interactions==
RIN1 has been shown to [[Protein-protein interaction|interact]] with [[HRAS]].<ref name=pmid15031288>{{cite journal |last=Mitin |first=Natalia Y |authorlink= |author2=Ramocki Melissa B |author3=Zullo Alfred J |author4=Der Channing J |author5=Konieczny Stephen F |author6=Taparowsky Elizabeth J  |date=May 2004 |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization |journal=J. Biol. Chem. |volume=279 |issue=21 |pages=22353–61 |publisher= |location = United States| issn = 0021-9258| pmid = 15031288 |doi = 10.1074/jbc.M312867200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid7862125>{{cite journal |last=Han |first=L |authorlink= |author2=Colicelli J  |date=Mar 1995 |title=A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1 |journal=Mol. Cell. Biol. |volume=15 |issue=3 |pages=1318–23 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 7862125 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=230355 | doi=10.1128/mcb.15.3.1318}}</ref>
Additionally, RIN1 binds and activates ABL family tyrosine kinases.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Colicelli J, Nicolette C, Birchmeier C, ''et al.'' |title=Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2913-7 |year= 1991 |pmid= 1849280 |doi=  }}
*{{cite journal  |vauthors=Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J |title=The RAS effector RIN1 modulates the formation of aversive memories |journal=J. Neurosci. |volume=23 |issue= 3 |pages= 748–757 |year= 2003 |pmid= 12574403|doi=  }}
*{{cite journal  | author=Trowbridge IS, Lesley J, Trotter J, Hyman R |title=Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene. |journal=Nature |volume=315 |issue= 6021 |pages= 666-9 |year= 1985 |pmid= 3874369 |doi=  }}
*{{cite journal  |vauthors=Trowbridge IS, Lesley J, Trotter J, Hyman R |title=Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene |journal=Nature |volume=315 |issue= 6021 |pages= 666–9 |year= 1985 |pmid= 3874369 |doi=10.1038/315666a0 |bibcode=1985Natur.315..666T }}
*{{cite journal  | author=Han L, Colicelli J |title=A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1318-23 |year= 1995 |pmid= 7862125 |doi=  }}
*{{cite journal  |vauthors=Han L, Colicelli J |title=A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1 |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1318–23 |year= 1995 |pmid= 7862125 |doi= 10.1128/mcb.15.3.1318| pmc=230355 }}
*{{cite journal  | author=Han L, Wong D, Dhaka A, ''et al.'' |title=Protein binding and signaling properties of RIN1 suggest a unique effector function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 4954-9 |year= 1997 |pmid= 9144171 |doi= }}
*{{cite journal  | author=Afar DE |title=Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1 |journal=Immunity |volume=6 |issue= 6 |pages= 773–82 |year= 1997 |pmid= 9208849 |doi=10.1016/S1074-7613(00)80452-5 |name-list-format=vanc| author2=Han L | author3=McLaughlin J | display-authors=3  | last4=Wong  | first4=Stephane  | last5=Dhaka  | first5=Ajay  | last6=Parmar  | first6=Kalindi  | last7=Rosenberg  | first7=Naomi  | last8=Witte  | first8=Owen N  | last9=Colicelli  | first9=John }}
*{{cite journal | author=Afar DE, Han L, McLaughlin J, ''et al.'' |title=Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. |journal=Immunity |volume=6 |issue= 6 |pages= 773-82 |year= 1997 |pmid= 9208849 |doi=  }}
*{{cite journal  |vauthors=Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF |title=Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1 |journal=Dev. Cell |volume=1 |issue= 1 |pages= 73–82 |year= 2001 |pmid= 11703925 |doi=10.1016/S1534-5807(01)00008-9  }}
*{{cite journal  | author=Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF |title=Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. |journal=Dev. Cell |volume=1 |issue= 1 |pages= 73-82 |year= 2001 |pmid= 11703925 |doi= }}
*{{cite journal  | author=Wang Y |title=The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 916–26 |year= 2002 |pmid= 11784866 |doi=10.1128/MCB.22.3.916-926.2001 | pmc=133556 |name-list-format=vanc| author2=Waldron RT  | author3=Dhaka A  | display-authors=3  | last4=Patel  | first4=A. | last5=Riley  | first5=M. M.  | last6=Rozengurt  | first6=E.  | last7=Colicelli  | first7=J. }}
*{{cite journal  | author=Wang Y, Waldron RT, Dhaka A, ''et al.'' |title=The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 916-26 |year= 2002 |pmid= 11784866 |doi=  }}
*{{cite journal  | author=Murphy GA |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966–75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 |name-list-format=vanc| author2=Graham SM  | author3=Morita S  | display-authors=3  | last4=Reks  | first4=SE  | last5=Rogers-Graham  | first5=K  | last6=Vojtek  | first6=A  | last7=Kelley  | first7=GG  | last8=Der  | first8=CJ }}
*{{cite journal | author=Murphy GA, Graham SM, Morita S, ''et al.'' |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966-75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mitin NY |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200  |name-list-format=vanc| author2=Ramocki MB  | author3=Zullo AJ  | display-authors=3  | last4=Der  | first4=CJ  | last5=Konieczny  | first5=SF  | last6=Taparowsky  | first6=EJ }}
*{{cite journal | author=Mitin NY, Ramocki MB, Zullo AJ, ''et al.'' |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353-61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Hu H, Bliss JM, Wang Y, Colicelli J |title=RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration |journal=Curr. Biol. |volume=15 |issue= 9 |pages= 815–23 |year= 2005 |pmid= 15886098 |doi= 10.1016/j.cub.2005.03.049 }}
*{{cite journal | author=Hu H, Bliss JM, Wang Y, Colicelli J |title=RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. |journal=Curr. Biol. |volume=15 |issue= 9 |pages= 815-23 |year= 2005 |pmid= 15886098 |doi= 10.1016/j.cub.2005.03.049 }}
*{{cite journal  | author=Zhang Y |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200  |name-list-format=vanc| author2=Wolf-Yadlin A  | author3=Ross PL  | display-authors=3  | last4=Pappin  | first4=DJ  | last5=Rush  | first5=J  | last6=Lauffenburger  | first6=DA  | last7=White  | first7=FM }}
*{{cite journal  | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija |bibcode=2005Natur.437.1173R}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Hunker CM |title=Rin1 regulates insulin receptor signal transduction pathways |journal=Exp. Cell Res. |volume=312 |issue= 7 |pages= 1106–18 |year= 2006 |pmid= 16457816 |doi= 10.1016/j.yexcr.2005.12.021  |name-list-format=vanc| author2=Giambini H  | author3=Galvis A  | display-authors=3  | last4=Hall  | first4=J.  | last5=Kruk  | first5=I.  | last6=Veisaga  | first6=M.L.  | last7=Barbieri  | first7=M.A. }}
*{{cite journal  | author=Hunker CM, Giambini H, Galvis A, ''et al.'' |title=Rin1 regulates insulin receptor signal transduction pathways. |journal=Exp. Cell Res. |volume=312 |issue= 7 |pages= 1106-18 |year= 2006 |pmid= 16457816 |doi= 10.1016/j.yexcr.2005.12.021 }}
*{{cite journal  | author=Beausoleil SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240  |name-list-format=vanc| author2=Villén J  | author3=Gerber SA  | display-authors=3  | last4=Rush  | first4=John  | last5=Gygi  | first5=Steven P }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Senda K |title=Analysis of RIN1 gene expression in colorectal cancer |journal=Oncol. Rep. |volume=17 |issue= 5 |pages= 1171–5 |year= 2007 |pmid= 17390061 |doi=  10.3892/or.17.5.1171|name-list-format=vanc| author2=Goi T  | author3=Hirono Y  | display-authors=3  | last4=Katayama  | first4=K  | last5=Yamaguchi  | first5=A }}
*{{cite journal | author=Senda K, Goi T, Hirono Y, ''et al.'' |title=Analysis of RIN1 gene expression in colorectal cancer. |journal=Oncol. Rep. |volume=17 |issue= 5 |pages= 1171-5 |year= 2007 |pmid= 17390061 |doi= }}
*{{cite journal  |vauthors=Kong C, Su X, Chen PI, Stahl PD |title=Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15294–301 |year= 2007 |pmid= 17403676 |doi= 10.1074/jbc.M611538200 }}
*{{cite journal  | author=Kong C, Su X, Chen PI, Stahl PD |title=Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15294-301 |year= 2007 |pmid= 17403676 |doi= 10.1074/jbc.M611538200 }}
}}
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Latest revision as of 01:41, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.[1][2][3]


Interactions

RIN1 has been shown to interact with HRAS.[4][5]

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

References

  1. ↑ Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
  2. ↑ Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
  3. ↑ "Entrez Gene: RIN1 Ras and Rab interactor 1".
  4. ↑ Mitin, Natalia Y; Ramocki Melissa B; Zullo Alfred J; Der Channing J; Konieczny Stephen F; Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. United States. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
  5. ↑ Han, L; Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. UNITED STATES. 15 (3): 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355. PMID 7862125.

Further reading



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