ROBO1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Roundabout homolog 1''' is a [[protein]] that in humans is encoded by the ''ROBO1'' [[gene]].<ref name="pmid9458045">{{cite journal | vauthors = Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G | title = Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors | journal = Cell | volume = 92 | issue = 2 | pages = 205–15 |date=Feb 1998 | pmid = 9458045 | pmc =  | doi =10.1016/S0092-8674(00)80915-0  }}</ref><ref name="pmid9608531">{{cite journal | vauthors = Sundaresan V, Roberts I, Bateman A, Bankier A, Sheppard M, Hobbs C, Xiong J, Minna J, Latif F, Lerman M, Rabbitts P | title = The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression | journal = Mol Cell Neurosci | volume = 11 | issue = 1–2 | pages = 29–35 |date=Aug 1998 | pmid = 9608531 | pmc = | doi = 10.1006/mcne.1998.0672 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6091| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Roundabout, axon guidance receptor, homolog 1 (Drosophila)
| HGNCid = 10249
| Symbol = ROBO1
| AltSymbols =; DUTT1; FLJ21882; MGC131599; MGC133277; SAX3
| OMIM = 602430
| ECnumber = 
| Homologene = 2206
| MGIid = 1274781
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008046 |text = axon guidance receptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0030673 |text = axolemma}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0050772 |text = positive regulation of axonogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6091
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002932
    | Hs_RefseqmRNA = NM_002941
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19876
    | Mm_Ensembl = ENSMUSG00000022883
    | Mm_RefseqmRNA = NM_019413
    | Mm_RefseqProtein = NP_062286
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 72624802
    | Mm_GenLoc_end = 72925867
    | Mm_Uniprot = Q3UUE8
  }}
}}
'''Roundabout, axon guidance receptor, homolog 1 (Drosophila)''', also known as '''ROBO1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6091| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some [[axon]]s project toward and across the midline in response to long-range [[chemotaxis|chemoattractants]] emanating from the midline]. In [[Drosophila]], the roundabout gene, a member of the [[immunoglobulin]] gene superfamily, encodes an [[integral membrane protein]] that is both an [[axon guidance]] receptor and a [[cell adhesion]] receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. In Drosophila, the roundabout gene, a member of the immunoglobulin gene superfamily, encodes an integral membrane protein that is both an axon guidance receptor and a cell adhesion receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6091| accessdate = }}</ref>
 
}}
''ROBO1'' was implicated in communication disorder based on a Finnish pedigree with severe [[dyslexia]]. Analyses revealed a translocation had occurred disrupting ''ROBO1''.<ref name="pmid16254601">{{cite journal | vauthors = Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kääriäinen H, Kere J | title = The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia | journal = PLoS Genet. | volume = 1 | issue = 4 | pages = e50 |date=October 2005 | pmid = 16254601 | pmc = 1270007 | doi = 10.1371/journal.pgen.0010050 }}</ref> Study of the  [[Baddeley's model of working memory|phonological memory]] component of  the [[Language acquisition|language acquisition system]] suggests that ''ROBO1'' polymorphisms are associated with functioning  in this system.<ref name="pmid20949370">{{cite journal | vauthors = Bates TC, Luciano M, Medland SE, Montgomery GW, Wright MJ, Martin NG | title = Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits | journal = Behav. Genet. | volume = 41 | issue = 1 | pages = 50–7 |date=January 2011 | pmid = 20949370 | doi = 10.1007/s10519-010-9402-9 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Sundaresan V, Chung G, Heppell-Parton A, etal |title=Homozygous deletions at 3p12 in breast and lung cancer |journal=Oncogene |volume=17 |issue= 13 |pages= 1723–9 |year= 1998 |pmid= 9796701 |doi= 10.1038/sj.onc.1202103 }}
| citations =
*{{cite journal  | vauthors=Zhao XC, Zhang LM, Li Q, Tong DY, Fan LC, An P, Wu XY, Chen WM, Zhao P, Wang J |title=Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1. |journal=Brain Res. |volume=1537 |pages= 283–9 |year= 2013 |pmid= 23994690 |doi=10.1016/j.brainres.2013.08.036 |pmc=3820100}}
*{{cite journal | author=Kidd T, Brose K, Mitchell KJ, ''et al.'' |title=Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. |journal=Cell |volume=92 |issue= 2 |pages= 205-15 |year= 1998 |pmid= 9458045 |doi= }}
*{{cite journal   |vauthors=Brose K, Bland KS, Wang KH, etal |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance |journal=Cell |volume=96 |issue= 6 |pages= 795–806 |year= 1999 |pmid= 10102268 |doi=10.1016/S0092-8674(00)80590-5  }}
*{{cite journal  | author=Sundaresan V, Roberts I, Bateman A, ''et al.'' |title=The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 1-2 |pages= 29-35 |year= 1998 |pmid= 9608531 |doi= 10.1006/mcne.1998.0672 }}
*{{cite journal   |vauthors=Yuan W, Zhou L, Chen JH, etal |title=The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance |journal=Dev. Biol. |volume=212 |issue= 2 |pages= 290–306 |year= 1999 |pmid= 10433822 |doi= 10.1006/dbio.1999.9371 }}
*{{cite journal | author=Sundaresan V, Chung G, Heppell-Parton A, ''et al.'' |title=Homozygous deletions at 3p12 in breast and lung cancer. |journal=Oncogene |volume=17 |issue= 13 |pages= 1723-9 |year= 1998 |pmid= 9796701 |doi= 10.1038/sj.onc.1202103 }}
*{{cite journal   |vauthors=Bashaw GJ, Kidd T, Murray D, etal |title=Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor |journal=Cell |volume=101 |issue= 7 |pages= 703–15 |year= 2000 |pmid= 10892742 |doi=10.1016/S0092-8674(00)80883-1  }}
*{{cite journal | author=Brose K, Bland KS, Wang KH, ''et al.'' |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795-806 |year= 1999 |pmid= 10102268 |doi= }}
*{{cite journal   |vauthors=Nguyen Ba-Charvet KT, Brose K, Ma L, etal |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11404413 |doi=  }}
*{{cite journal | author=Yuan W, Zhou L, Chen JH, ''et al.'' |title=The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. |journal=Dev. Biol. |volume=212 |issue= 2 |pages= 290-306 |year= 1999 |pmid= 10433822 |doi= 10.1006/dbio.1999.9371 }}
*{{cite journal   |vauthors=Wong K, Ren XR, Huang YZ, etal |title=Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway |journal=Cell |volume=107 |issue= 2 |pages= 209–21 |year= 2001 |pmid= 11672528 |doi=10.1016/S0092-8674(01)00530-X  }}
*{{cite journal | author=Bashaw GJ, Kidd T, Murray D, ''et al.'' |title=Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. |journal=Cell |volume=101 |issue= 7 |pages= 703-15 |year= 2000 |pmid= 10892742 |doi=  }}
*{{cite journal   |vauthors=Dallol A, Forgacs E, Martinez A, etal |title=Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers |journal=Oncogene |volume=21 |issue= 19 |pages= 3020–8 |year= 2002 |pmid= 12082532 |doi= 10.1038/sj.onc.1205421 }}
*{{cite journal | author=Nguyen Ba-Charvet KT, Brose K, Ma L, ''et al.'' |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281-9 |year= 2001 |pmid= 11404413 |doi= }}
*{{cite journal   |vauthors=Latil A, Chêne L, Cochant-Priollet B, etal |title=Quantification of expression of netrins, slits and their receptors in human prostate tumors |journal=Int. J. Cancer |volume=103 |issue= 3 |pages= 306–15 |year= 2003 |pmid= 12471613 |doi= 10.1002/ijc.10821 }}
*{{cite journal | author=Wong K, Ren XR, Huang YZ, ''et al.'' |title=Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. |journal=Cell |volume=107 |issue= 2 |pages= 209-21 |year= 2001 |pmid= 11672528 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Dallol A, Forgacs E, Martinez A, ''et al.'' |title=Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. |journal=Oncogene |volume=21 |issue= 19 |pages= 3020-8 |year= 2002 |pmid= 12082532 |doi= 10.1038/sj.onc.1205421 }}
*{{cite journal   |vauthors=Hivert B, Liu Z, Chuang CY, etal |title=Robo1 and Robo2 are homophilic binding molecules that promote axonal growth |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 534–45 |year= 2003 |pmid= 12504588 |doi=10.1006/mcne.2002.1193  }}
*{{cite journal | author=Latil A, Chêne L, Cochant-Priollet B, ''et al.'' |title=Quantification of expression of netrins, slits and their receptors in human prostate tumors. |journal=Int. J. Cancer |volume=103 |issue= 3 |pages= 306-15 |year= 2003 |pmid= 12471613 |doi= 10.1002/ijc.10821 }}
*{{cite journal   |vauthors=Wang B, Xiao Y, Ding BB, etal |title=Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity |journal=Cancer Cell |volume=4 |issue= 1 |pages= 19–29 |year= 2004 |pmid= 12892710 |doi=10.1016/S1535-6108(03)00164-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Hivert B, Liu Z, Chuang CY, ''et al.'' |title=Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 534-45 |year= 2003 |pmid= 12504588 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Wang B, Xiao Y, Ding BB, ''et al.'' |title=Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. |journal=Cancer Cell |volume=4 |issue= 1 |pages= 19-29 |year= 2004 |pmid= 12892710 |doi= }}
*{{cite journal   |vauthors=Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, etal |title=The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia |journal=PLoS Genet. |volume=1 |issue= 4 |pages= e50 |year= 2006 |pmid= 16254601 |doi= 10.1371/journal.pgen.0010050  | pmc=1270007 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N, etal |title=Inhibition of medulloblastoma cell invasion by Slit |journal=Oncogene |volume=25 |issue= 37 |pages= 5103–12 |year= 2006 |pmid= 16636676 |doi= 10.1038/sj.onc.1209524  | pmc=2072874 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Muzny DM, Scherer SE, Kaul R, etal |title=The DNA sequence, annotation and analysis of human chromosome 3 |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
*{{cite journal | author=Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, ''et al.'' |title=The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. |journal=PLoS Genet. |volume=1 |issue= 4 |pages= e50 |year= 2006 |pmid= 16254601 |doi= 10.1371/journal.pgen.0010050 }}
*{{cite journal   |vauthors=Gröne J, Doebler O, Loddenkemper C, etal |title=Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer |journal=Oncol. Rep. |volume=15 |issue= 6 |pages= 1437–43 |year= 2007 |pmid= 16685377 |doi= 10.3892/or.15.6.1437}}
*{{cite journal | author=Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N, ''et al.'' |title=Inhibition of medulloblastoma cell invasion by Slit. |journal=Oncogene |volume=25 |issue= 37 |pages= 5103-12 |year= 2006 |pmid= 16636676 |doi= 10.1038/sj.onc.1209524 }}
*{{cite journal   |vauthors=Ito H, Funahashi S, Yamauchi N, etal |title=Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target |journal=Clin. Cancer Res. |volume=12 |issue= 11 Pt 1 |pages= 3257–64 |year= 2007 |pmid= 16740745 |doi= 10.1158/1078-0432.CCR-05-2787 }}
*{{cite journal | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
*{{cite journal  | author=Gröne J, Doebler O, Loddenkemper C, ''et al.'' |title=Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. |journal=Oncol. Rep. |volume=15 |issue= 6 |pages= 1437-43 |year= 2007 |pmid= 16685377 |doi=  }}
*{{cite journal | author=Ito H, Funahashi S, Yamauchi N, ''et al.'' |title=Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. |journal=Clin. Cancer Res. |volume=12 |issue= 11 Pt 1 |pages= 3257-64 |year= 2007 |pmid= 16740745 |doi= 10.1158/1078-0432.CCR-05-2787 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:23, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.[1][2][3]

Function

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline]. In Drosophila, the roundabout gene, a member of the immunoglobulin gene superfamily, encodes an integral membrane protein that is both an axon guidance receptor and a cell adhesion receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.[3]

Clinical significance

ROBO1 was implicated in communication disorder based on a Finnish pedigree with severe dyslexia. Analyses revealed a translocation had occurred disrupting ROBO1.[4] Study of the phonological memory component of the language acquisition system suggests that ROBO1 polymorphisms are associated with functioning in this system.[5]

References

  1. ↑ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
  2. ↑ Sundaresan V, Roberts I, Bateman A, Bankier A, Sheppard M, Hobbs C, Xiong J, Minna J, Latif F, Lerman M, Rabbitts P (Aug 1998). "The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression". Mol Cell Neurosci. 11 (1–2): 29–35. doi:10.1006/mcne.1998.0672. PMID 9608531.
  3. ↑ 3.0 3.1 "Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)".
  4. ↑ Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kääriäinen H, Kere J (October 2005). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLoS Genet. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMC 1270007. PMID 16254601.
  5. ↑ Bates TC, Luciano M, Medland SE, Montgomery GW, Wright MJ, Martin NG (January 2011). "Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits". Behav. Genet. 41 (1): 50–7. doi:10.1007/s10519-010-9402-9. PMID 20949370.

Further reading


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