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{{ | '''Ras-related protein R-Ras2''' is a [[protein]] that in humans is encoded by the ''RRAS2'' [[gene]].<ref name="pmid2108320">{{cite journal |vauthors=Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P | title = Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line | journal = Mol Cell Biol | volume = 10 | issue = 4 | pages = 1793–8 |date=May 1990 | pmid = 2108320 | pmc = 362288 | doi = }}</ref><ref name="pmid8052619">{{cite journal |vauthors=Chan AM, Miki T, Meyers KA, Aaronson SA | title = A human oncogene of the RAS superfamily unmasked by expression cDNA cloning | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7558–62 |date=September 1994 | pmid = 8052619 | pmc = 44441 | doi =10.1073/pnas.91.16.7558 | bibcode =1994PNAS...91.7558C }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800| accessdate = }}</ref> | ||
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==Interactions== | |||
RRAS2 has been shown to [[Protein-protein interaction|interact]] with [[C-Raf]].<ref name=pmid10783161>{{cite journal |last=Li |first=W |authorlink= |author2=Han M |author3=Guan K L |date=April 2000 |title=The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf |journal=Genes Dev. |volume=14 |issue=8 |pages=895–900 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 10783161 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=316541 }}</ref><ref name=pmid10557073>{{cite journal |last=Movilla |first=N |authorlink= |author2=Crespo P |author3=Bustelo X R |date=October 1999 |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins |journal=Oncogene |volume=18 |issue=43 |pages=5860–9 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10557073 |doi = 10.1038/sj.onc.1202968 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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*{{cite journal | | *{{cite journal |vauthors=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=10.1016/S0301-472X(02)00904-9 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Rosário M, Paterson HF, Marshall CJ |title=Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1270–9 |year= 1999 |pmid= 10064593 |doi= 10.1093/emboj/18.5.1270 | pmc=1171217 }} | ||
*{{cite journal | *{{cite journal |vauthors=Linnemann T, Geyer M, Jaitner BK, etal |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556–62 |year= 1999 |pmid= 10224125 |doi=10.1074/jbc.274.19.13556 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ehrhardt GR, Leslie KB, Lee F, etal |title=M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. |journal=Blood |volume=94 |issue= 7 |pages= 2433–44 |year= 1999 |pmid= 10498616 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Movilla N, Crespo P, Bustelo XR |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. |journal=Oncogene |volume=18 |issue= 43 |pages= 5860–9 |year= 1999 |pmid= 10557073 |doi= 10.1038/sj.onc.1202968 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ohba Y, Mochizuki N, Yamashita S, etal |title=Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20020–6 |year= 2000 |pmid= 10777492 |doi= 10.1074/jbc.M000981200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Figueroa C, Taylor J, Vojtek AB |title=Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28219–25 |year= 2001 |pmid= 11335720 |doi= 10.1074/jbc.M101763200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Murphy GA, Graham SM, Morita S, etal |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966–75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rong R, He Q, Liu Y, etal |title=TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. |journal=Oncogene |volume=21 |issue= 7 |pages= 1062–70 |year= 2002 |pmid= 11850823 |doi= 10.1038/sj.onc.1205154 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, etal |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381–90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | | *{{cite journal |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mitin NY, Ramocki MB, Zullo AJ, etal |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kho Y, Kim SC, Jiang C, etal |title=A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12479–84 |year= 2004 |pmid= 15308774 |doi= 10.1073/pnas.0403413101 | pmc=515085 |bibcode=2004PNAS..10112479K }} | ||
*{{cite journal | *{{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=22800}} | |||
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Latest revision as of 01:49, 26 June 2018
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.[1][2][3]
Interactions
RRAS2 has been shown to interact with C-Raf.[4][5]
References
- ↑ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. PMC 362288. PMID 2108320.
- ↑ Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi:10.1073/pnas.91.16.7558. PMC 44441. PMID 8052619.
- ↑ "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2".
- ↑ Li, W; Han M; Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. UNITED STATES. 14 (8): 895–900. ISSN 0890-9369. PMC 316541. PMID 10783161.
- ↑ Movilla, N; Crespo P; Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. ENGLAND. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073.
Further reading
- Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together". Exp. Hematol. 30 (10): 1089–106. doi:10.1016/S0301-472X(02)00904-9. PMID 12384139.
- Rosário M, Paterson HF, Marshall CJ (1999). "Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells". EMBO J. 18 (5): 1270–9. doi:10.1093/emboj/18.5.1270. PMC 1171217. PMID 10064593.
- Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
- Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. PMID 10498616.
- Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. PMID 10557073.
- Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3". J. Biol. Chem. 275 (26): 20020–6. doi:10.1074/jbc.M000981200. PMID 10777492.
- Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". J. Biol. Chem. 276 (30): 28219–25. doi:10.1074/jbc.M101763200. PMID 11335720.
- Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
- Rong R, He Q, Liu Y, et al. (2002). "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway". Oncogene. 21 (7): 1062–70. doi:10.1038/sj.onc.1205154. PMID 11850823.
- Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
- Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi:10.1073/pnas.0403413101. PMC 515085. PMID 15308774.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
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