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{{Infobox_gene}}
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'''Ras suppressor protein 1''' is a [[protein]] that in humans is encoded by the ''RSU1'' [[gene]].<ref name="pmid8288261">{{cite journal | vauthors = Tsuda T, Cutler ML | title = Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10 | journal = Genomics | volume = 18 | issue = 2 | pages = 461–2 |date=Feb 1994 | pmid = 8288261 | pmc =  | doi = 10.1006/geno.1993.1503 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RSU1 Ras suppressor protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6251| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Ras suppressor protein 1
| HGNCid = 10464
| Symbol = RSU1
| AltSymbols =; FLJ31034; RSP-1
| OMIM = 179555
| ECnumber =
| Homologene = 7521
| MGIid = 103040
| GeneAtlas_image1 = PBB_GE_RSU1_201980_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =  
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6251
    | Hs_Ensembl = ENSG00000148484
    | Hs_RefseqProtein = NP_036557
    | Hs_RefseqmRNA = NM_012425
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 16672616
    | Hs_GenLoc_end = 16899533
    | Hs_Uniprot = Q15404
    | Mm_EntrezGene = 20163
    | Mm_Ensembl = ENSMUSG00000026727
    | Mm_RefseqmRNA = NM_009105
    | Mm_RefseqProtein = NP_033131
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 12994821
    | Mm_GenLoc_end = 13189161
    | Mm_Uniprot = Q9CSE4
  }}
}}
'''Ras suppressor protein 1''', also known as '''RSU1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RSU1 Ras suppressor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6251| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.<ref name="entrez">{{cite web | title = Entrez Gene: RSU1 Ras suppressor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6251| accessdate = }}</ref>
| summary_text = This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.<ref name="entrez" />
}}
}}
RSU-1 has also been seen to act as a structural protein in [[integrin]]-mediated [[Focal adhesion|focal-adhesion]] complexes. It bind strongly to the protein PINCH.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =  
*{{cite journal  | author=Cutler ML, Bassin RH, Zanoni L, Talbot N |title=Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. |journal=Mol. Cell. Biol. |volume=12 |issue= 9 |pages= 3750-6 |year= 1992 |pmid= 1508180 |doi=  }}
*{{cite journal  | vauthors=Cutler ML, Bassin RH, Zanoni L, Talbot N |title=Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation |journal=Mol. Cell. Biol. |volume=12 |issue= 9 |pages= 3750–6 |year= 1992 |pmid= 1508180 |doi= | pmc=360236 }}
*{{cite journal  | author=Tsuda T, Marinetti MR, Masuelli L, Cutler ML |title=The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential. |journal=Oncogene |volume=11 |issue= 2 |pages= 397-403 |year= 1995 |pmid= 7624154 |doi=  }}
*{{cite journal  | vauthors=Tsuda T, Marinetti MR, Masuelli L, Cutler ML |title=The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential |journal=Oncogene |volume=11 |issue= 2 |pages= 397–403 |year= 1995 |pmid= 7624154 |doi=  }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi=  }}
*{{cite journal   |vauthors=Matoba R, Okubo K, Hori N, etal |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Tsuda T, Cutler ML |title=Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. |journal=Genomics |volume=18 |issue= 2 |pages= 461-2 |year= 1994 |pmid= 8288261 |doi= 10.1006/geno.1993.1503 }}
*{{cite journal  | vauthors=Masuelli L, Cutler ML |title=Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5466–76 |year= 1996 |pmid= 8816460 |doi= | pmc=231547 }}
*{{cite journal  | author=Masuelli L, Cutler ML |title=Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5466-76 |year= 1996 |pmid= 8816460 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Chunduru S, Kawami H, Gullick R, etal |title=Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas |journal=J. Neurooncol. |volume=60 |issue= 3 |pages= 201–11 |year= 2003 |pmid= 12510772 |doi=10.1023/A:1021130620178 }}
*{{cite journal | author=Chunduru S, Kawami H, Gullick R, ''et al.'' |title=Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. |journal=J. Neurooncol. |volume=60 |issue= 3 |pages= 201-11 |year= 2003 |pmid= 12510772 |doi=  }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237–48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 | pmc=1134064 }}
*{{cite journal  | author=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237-48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Dougherty GW, Chopp T, Qi SM, Cutler ML |title=The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 168–79 |year= 2005 |pmid= 15878342 |doi= 10.1016/j.yexcr.2005.01.025 }}
*{{cite journal  | author=Dougherty GW, Chopp T, Qi SM, Cutler ML |title=The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 168-79 |year= 2005 |pmid= 15878342 |doi= 10.1016/j.yexcr.2005.01.025 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:32, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.[1][2]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.[2] RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

References

  1. ↑ Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics. 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.
  2. ↑ 2.0 2.1 "Entrez Gene: RSU1 Ras suppressor protein 1".

Further reading



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