RTN3: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Reticulon-3''' is a [[protein]] that in humans is encoded by the ''RTN3'' [[gene]].<ref name="pmid10331947">{{cite journal |vauthors=Moreira EF, Jaworski CJ, Rodriguez IR | title = Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13 | journal = Genomics | volume = 58 | issue = 1 | pages = 73–81 |date=Jul 1999 | pmid = 10331947 | pmc =  | doi = 10.1006/geno.1999.5807 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RTN3 reticulon 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10313| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Reticulon 3
| HGNCid = 10469
| Symbol = RTN3
| AltSymbols =; HAP; ASYIP; NSPL2; NSPLII; RTN3-A1
| OMIM = 604249
| ECnumber = 
| Homologene = 24934
| MGIid = 1339970
| GeneAtlas_image1 = PBB_GE_RTN3_219549_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10313
    | Hs_Ensembl = ENSG00000133318
    | Hs_RefseqProtein = NP_006045
    | Hs_RefseqmRNA = NM_006054
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 63205498
    | Hs_GenLoc_end = 63283913
    | Hs_Uniprot = O95197
    | Mm_EntrezGene = 20168
    | Mm_Ensembl = ENSMUSG00000024758
    | Mm_RefseqmRNA = NM_001003930
    | Mm_RefseqProtein = NP_001003930
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 7492945
    | Mm_GenLoc_end = 7550333
    | Mm_Uniprot = Q3UF62
  }}
}}
'''Reticulon 3''', also known as '''RTN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RTN3 reticulon 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10313| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RTN3 reticulon 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10313| accessdate = }}</ref>
| summary_text = The [[reticulons]] are a group of highly conserved genes with preferential [[gene expression|expression]] in [[neuroendocrine]] tissues (see, e.g., [[RTN1]]; MIM 600865).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
*{{cite journal | author=Moreira EF, Jaworski CJ, Rodriguez IR |title=Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. |journal=Genomics |volume=58 |issue= 1 |pages= 73-81 |year= 1999 |pmid= 10331947 |doi= 10.1006/geno.1999.5807 }}
*{{cite journal  |vauthors=Qu X, Qi Y, Qi B |title=Generation of multiple mRNA transcripts from the novel human apoptosis-inducing gene hap by alternative polyadenylation utilization and the translational activation function of 3' untranslated region |journal=Arch. Biochem. Biophys. |volume=400 |issue= 2 |pages= 233–44 |year= 2002 |pmid= 12054434 |doi= 10.1016/S0003-9861(02)00016-4 }}
*{{cite journal  | author=Qu X, Qi Y, Qi B |title=Generation of multiple mRNA transcripts from the novel human apoptosis-inducing gene hap by alternative polyadenylation utilization and the translational activation function of 3' untranslated region. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 2 |pages= 233-44 |year= 2002 |pmid= 12054434 |doi= 10.1016/S0003-9861(02)00016-4 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Qi B |title=Pro-apoptotic ASY/Nogo-B protein associates with ASYIP |journal=J. Cell. Physiol. |volume=196 |issue= 2 |pages= 312–8 |year= 2003 |pmid= 12811824 |doi= 10.1002/jcp.10297  |name-list-format=vanc| author2=Qi Y  | author3=Watari A | display-authors=3  | last4=Yoshioka  | first4=Naohisa  | last5=Inoue  | first5=Hirokazu  | last6=Minemoto  | first6=Yuzuru  | last7=Yamashita  | first7=Katsumi  | last8=Sasagawa  | first8=Toshiyuki  | last9=Yutsudo | first9=Masuo }}
*{{cite journal | author=Qi B, Qi Y, Watari A, ''et al.'' |title=Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. |journal=J. Cell. Physiol. |volume=196 |issue= 2 |pages= 312-8 |year= 2003 |pmid= 12811824 |doi= 10.1002/jcp.10297 }}
*{{cite journal  |vauthors=Oertle T, Klinger M, Stuermer CA, Schwab ME |title=A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family |journal=FASEB J. |volume=17 |issue= 10 |pages= 1238–47 |year= 2003 |pmid= 12832288 |doi= 10.1096/fj.02-1166hyp }}
*{{cite journal  | author=Oertle T, Klinger M, Stuermer CA, Schwab ME |title=A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. |journal=FASEB J. |volume=17 |issue= 10 |pages= 1238-47 |year= 2003 |pmid= 12832288 |doi= 10.1096/fj.02-1166hyp }}
*{{cite journal  | author=Di Sano F |title=Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells |journal=Cancer Res. |volume=63 |issue= 14 |pages= 3860–5 |year= 2003 |pmid= 12873973 |doi=  |name-list-format=vanc| author2=Fazi B  | author3=Citro G | display-authors=3  | last4=Lovat  | first4=PE  | last5=Cesareni  | first5=G  | last6=Piacentini  | first6=M  }}
*{{cite journal | author=Di Sano F, Fazi B, Citro G, ''et al.'' |title=Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. |journal=Cancer Res. |volume=63 |issue= 14 |pages= 3860-5 |year= 2003 |pmid= 12873973 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3 | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Huang X |title=Overexpression of human reticulon 3 (hRTN3) in astrocytoma |journal=Clin. Neuropathol. |volume=23 |issue= 1 |pages= 1–7 |year= 2004 |pmid= 14986927 |doi=  |name-list-format=vanc| author2=Yang H  | author3=Zhou Y | display-authors=3  | last4=Liu  | first4=J  | last5=Yin  | first5=B  | last6=Peng  | first6=X  | last7=Qiang  | first7=B | last8=Yuan  | first8=J  }}
*{{cite journal  | author=Huang X, Yang H, Zhou Y, ''et al.'' |title=Overexpression of human reticulon 3 (hRTN3) in astrocytoma. |journal=Clin. Neuropathol. |volume=23 |issue= 1 |pages= 1-7 |year= 2004 |pmid= 14986927 |doi=  }}
*{{cite journal  | author=Hu Y |title=90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29325–35 |year= 2004 |pmid= 15117958 |doi= 10.1074/jbc.M311144200 |name-list-format=vanc| author2=Fang X  | author3=Dunham SM  | display-authors=3  | last4=Prada  | first4=C  | last5=Stachowiak  | first5=EK  | last6=Stachowiak  | first6=MK }}
*{{cite journal | author=Hu Y, Fang X, Dunham SM, ''et al.'' |title=90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29325-35 |year= 2004 |pmid= 15117958 |doi= 10.1074/jbc.M311144200 }}
*{{cite journal  | author=He W |title=Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation |journal=Nat. Med. |volume=10 |issue= 9 |pages= 959–65 |year= 2004 |pmid= 15286784 |doi= 10.1038/nm1088  |name-list-format=vanc| author2=Lu Y  | author3=Qahwash I  | display-authors=3  | last4=Hu | first4=Xiang-You  | last5=Chang  | first5=Ansi  | last6=Yan  | first6=Riqiang }}
*{{cite journal  | author=He W, Lu Y, Qahwash I, ''et al.'' |title=Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. |journal=Nat. Med. |volume=10 |issue= 9 |pages= 959-65 |year= 2004 |pmid= 15286784 |doi= 10.1038/nm1088 }}
*{{cite journal | author=Di Scala F |title=Tissue specificity and regulation of the N-terminal diversity of reticulon 3 |journal=Biochem. J. |volume=385 |issue= Pt 1 |pages= 125–34 |year= 2005 |pmid= 15350194 |doi= 10.1042/BJ20040458  | pmc=1134680 |name-list-format=vanc| author2=Dupuis L  | author3=Gaiddon C  | display-authors=3  | last4=De Tapia  | first4=Marc  | last5=Jokic  | first5=Natasa  | last6=Gonzalez De Aguilar  | first6=Jose-Luis  | last7=Raul  | first7=Jean-Sébastien  | last8=Ludes  | first8=Bertrand  | last9=Loeffler  | first9=Jean-Philippe }}
*{{cite journal | author=Di Scala F, Dupuis L, Gaiddon C, ''et al.'' |title=Tissue specificity and regulation of the N-terminal diversity of reticulon 3. |journal=Biochem. J. |volume=385 |issue= Pt 1 |pages= 125-34 |year= 2005 |pmid= 15350194 |doi= 10.1042/BJ20040458 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gan M |title=Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death |journal=Mol. Biol. Rep. |volume=31 |issue= 3 |pages= 159–64 |year= 2005 |pmid= 15560370 |doi=10.1023/B:MOLE.0000043551.84883.c8  |name-list-format=vanc| author2=Qi Y  | author3=Wan Q  | display-authors=3  | last4=Kuang  | first4=Ersheng  | last5=Liu  | first5=Qingzhen  | last6=Liu  | first6=Xin  }}
*{{cite journal | author=Gan M, Qi Y, Wan Q, ''et al.'' |title=Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death. |journal=Mol. Biol. Rep. |volume=31 |issue= 3 |pages= 159-64 |year= 2005 |pmid= 15560370 |doi=  }}
*{{cite journal  | author=Kuang E |title=ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP) |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 549–59 |year= 2005 |pmid= 15799019 |doi= 10.1002/jcp.20340  |name-list-format=vanc| author2=Wan Q  | author3=Li X  | display-authors=3  | last4=Xu  | first4=Hua  | last5=Liu  | first5=Qingzhen  | last6=Qi  | first6=Yipeng }}
*{{cite journal  | author=Kuang E, Wan Q, Li X, ''et al.'' |title=ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 549-59 |year= 2005 |pmid= 15799019 |doi= 10.1002/jcp.20340 }}
*{{cite journal  | author=Cai Y |title=Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 2 |pages= 236–43 |year= 2005 |pmid= 15946766 |doi= 10.1016/j.molbrainres.2005.04.020  |name-list-format=vanc| author2=Saiyin H  | author3=Lin Q  | display-authors=3  | last4=Zhang  | first4=P  | last5=Tang  | first5=L  | last6=Pan  | first6=X  | last7=Yu  | first7=L }}
*{{cite journal | author=Cai Y, Saiyin H, Lin Q, ''et al.'' |title=Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 2 |pages= 236-43 |year= 2005 |pmid= 15946766 |doi= 10.1016/j.molbrainres.2005.04.020 }}
*{{cite journal  | author=Wakana Y |title=Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 4 |pages= 1198–205 |year= 2005 |pmid= 16054885 |doi= 10.1016/j.bbrc.2005.07.012  |name-list-format=vanc| author2=Koyama S  | author3=Nakajima K  | display-authors=3  | last4=Hatsuzawa  | first4=Kiyotaka  | last5=Nagahama  | first5=Masami  | last6=Tani  | first6=Katsuko  | last7=Hauri  | first7=Hans-Peter  | last8=Melançon  | first8=Paul  | last9=Tagaya  | first9=Mitsuo }}
*{{cite journal  | author=Wakana Y, Koyama S, Nakajima K, ''et al.'' |title=Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 4 |pages= 1198-205 |year= 2005 |pmid= 16054885 |doi= 10.1016/j.bbrc.2005.07.012 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |name-list-format=vanc| author2=Ota T  | author3=Nishikawa T  | display-authors=3  | last4=Hayashi  | first4=K  | last5=Suzuki  | first5=Y  | last6=Yamamoto  | first6=J  | last7=Wakamatsu  | first7=A  | last8=Kimura  | first8=K  | last9=Sakamoto  | first9=K }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
}}
}}
*{{cite journal  |vauthors=Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ |title=Widespread Distribution of Reticulon-3 in Various Neurodegenerative Diseases |journal=Neuropathology |volume=30|year= 2010 |pmid= 20374499  | pmc=2902651 |doi=10.1111/j.1440-1789.2010.01107.x  | issue=6  | pages=574–9 }}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|RTN3}}
* {{UCSC gene details|RTN3}}
 
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{{gene-11-stub}}

Latest revision as of 19:05, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.[1][2]

The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM][2]

References

  1. ↑ Moreira EF, Jaworski CJ, Rodriguez IR (Jul 1999). "Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13". Genomics. 58 (1): 73–81. doi:10.1006/geno.1999.5807. PMID 10331947.
  2. ↑ 2.0 2.1 "Entrez Gene: RTN3 reticulon 3".

Further reading

External links



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